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S E L E C T    P U B L I C A T I O N S   (by year)

2010 2011 2012 2013 2014 2015
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
1990 1991 1992 1993 1994 1995 1996 1997 1998 1999
1974-1979 1980-1986 1987 1988 1989

2015

  • Zhang, W., Cheng, L.E., Kittelmann, M., Li, J., Petkovic, M., Cheng, T., Jin, P., Guo, Z., Göpfert, M., Jan, L.Y., and Jan, Y.N. (2015). Ankyrin repeats convey force to gate the NOMPC mechanostransduction channel. Cell (in press).

  • Huang, X., He, Y., Dubuc, A.M., Hashizume, R., Zhang, W., Reimand, J., Yang, H., Wang, T.A., Stehbens, S.J., Younger, S., Barshow, S., Zhu, S., Cooper, M.K., Peacock, J., Ramaswamy V., Garzia, L., Wu, X., Remke, M., Forester, C.M., Kim, C.C., Weiss, W.A., James, C.D., Shuman, M.A., Bader, G.D., Mueller, S., Taylor, M.D., Jan, Y.N., and Jan, L.Y. (2015). EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat. Neurosci. Aug 10. doi: 10.1038/nn.4088. [Epub ahead of print]. PMID: 26258683. [PubMedCentral]

  • Yu, D., Baird, M.A., Allen, J.R., Howes, E.S., Klassen, M.P., Reade, A., Makhijani, K., Song, Y., Liu, S., Murthy, Z., Zhang, S.Q., Weiner, O.D., Kornberg, T.B., Jan, Y.N., and Davidson, M.W., and Shu, X. (2015). A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nat Methods 12:763-5. PMCID: PMC4521985. [PubMedCentral]

  • Song, Y., Sretavan, D., Salegio, E.A., Berg, J., Huang, X., Cheng, T., Xiong, X., Meltzer, S., Han, C., Nguyen, T.T., Bresnahan, J.C., Beattie, M.S., Jan, L.Y., and Jan, Y.N. (2015). Regulation of Axon regeneration by the RNA repair and splicing pathway. Nat Neurosci. 18:817-25. PMCID: PMC4446171. [PubMedCentral]

  • To, T.L., Piggott, B.J., Makhijani, K., Yu, D., Jan, Y.N., and Shu, X. (2015). Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo. PNAS USA 112:3338-43. PMCID: PMC4371907. [PubMedCentral]

  • Soba, P., Han, C., Zheng, Y., Perea, D., Miguel-Aliaga, I., Jan, L.Y., and Jan, Y.N. (2015) The Ret receptor regulates sensory neuron dendrite growth and integrin mediates adhesion. Elife. 2015 Mar 12;4. doi: 10.7554/eLife.05491. PMCID: PMC4391025. [PubMedCentral]

  • Shen, Y., Ge, W.P., Li, Y., Hirano, A., Lee, H.Y., Rohlmann, A., Missler, M., Tsien, R.W., Jan, L.Y., Fu, Y.H., and Ptáček, L.J. (2015) Protein mutated in paroxysmal dyskinesia interacts with the active zone protein RIM and suppresses synaptic vesicle exocytosis. PNAS USA 112:2935-41. PMCID: PMC4364199. [PubMedCentral]

  • Peters, C.J., Yu, H., Tien, J., Jan, Y.N., Li, M., and Jan L.Y. (2015). Four basic residues critical for the ion selectivity and pore blocker sensitivity of TMEM16A calcium-activated chloride channels. PNAS USA 112:3547-52. PMCID: PMC4371966. [PubMedCentral]

2014

  • Feenstra, B., Pasternak, B., Geller, F., Carstensen, L. Wang, T., Huang, F., Eitson, J.L., Hollegaard, M.V., Svanström, H., Vestergaard, M., Hougaard, D.M., Schoggins, J.W., Jan, L.Y, Melbye, M., and Hviid, A. (2014). Common variants associated with general and MMR vaccine-related febrile seizures. Nature Genetics 6:1274-82. PMCID: PMC4244308. [PubMedCentral]

  • Gorczyca, D.A., Younger, S., Meltzer, S., Kim, S.E., Cheng, L., Song, W., Lee, H.Y., Jan, L.Y., and Jan, Y.N. (2014). Identification of Ppk26, a DEG/ENaC channel functioning with Ppk1 in a mutually dependent manner to guide locomotion behavior in Drosophila. Cell Rep. 9:1446-58. PMCID: PMC4254518. [PubMedCentral]

  • Ultanir, S.K., Yadav, S., Hertz, N.T., Oses-Prieto, J.A., Claxton, S., Burlingame, A.L., Shokat, K.M., Jan, L.Y., and Jan, Y.N. (2014). MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development. Neuron 84:968-82. PMCID: 4407996. [PubMedCentral]

  • Zhang, W., Yan, Z., Li, B., Jan, L.Y., and Jan, Y.N. (2014). Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. Elife. Oct 30;3. Doi: 10.7554/eLife.03293. PMCID: PMC4244571. [PubMedCentral]

  • Bagley, J.A., Yan, Z., Zhang, W., Wildonger, J., Jan, L.Y., and Jan Y.N. (2014). Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function. Genes Dev. 28:1940-1956. PMCID: PMC4197945. [PubMedCentral]

  • Huang, X., and Jan, L.Y. (2014). Targeting potassium channels in cancer. J Cell Biol 206:151-162. PMCID: PMC4107787. [PubMedCentral]

  • Tien, J., Peters, C.J., Wong, X.M., Cheng, T., Jan, Y.N., Jan, L.Y., and Yang, H. (2014). A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. eLife 2014 3:e02772. PMCID: PMC4112547. [PubMedCentral]

  • Hong, T., Yang, H., Zhang, S.S., Cho, H.C., Kalashnikova, M., Sun, B., Zhang, H., Bhargava, A., Grabe, M., Olgin, J., Gorelik, J., Marbán, E., Jan, L.Y., and Shaw, R.M. (2014). Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med. 20:624-32. PMCID: PMC4048325. [PubMedCentral]

  • Yu, D., Gustafson, W.C., Han, C., Lafaye, C., Noirclerc-Savoye, M., Ge, W.P. Thayer, D.A., Huang, H., Kornberg, T.B. Royant, A., Jan, L.Y., Jan, Y.N., Weiss, W.A., and Shu X. (2014). An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nature Comm 5:3626. PMCID: PMC4077998. [PDF]

  • Jan, L.Y. (2014) Q & A Lily Jan. Curr Biol. Mar 24:R212-3. PMID: 24795915. [PDF]

  • Jan, Y.N., and Jan, L.Y. (2014) The History of Neuroscience in Autobiography. Society of Neuroscience, History of Neuroscience, Autobiographical Chapters. Volume 8. [PDF]

  • Parrish, J.Z., Kim, C.C., Tang, L., Bergquist, S., Want, T., Derisi, J.l., Jan, L.Y., Jan, Y.N., and Davis, G.W. (2014) Krüppel mediates the selective rebalancing of ion channel expression. Neuron 82:537-44. PMCID: PMC4104505. [PubMedCentral]

  • Rumpf, S., Bagley, J.A., Thompson-Peer, K.L., Zhu, S., Gorczyca, D., Beckstead, R.B., Jan, L.Y., and Jan, Y.N. (2014) Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. Proc Natl Acad Sci USA 111:7331-6. PMCID: PMC4034197. [PubMedCentral]

  • Han, C., Song, Y., Wang, D., Franc, N.C., Jan, L.Y., and Jan, Y.N. (2014) Epidermal Cells are the Primary Phagocytes in the Fragmentation and Clearance of Degenerating Dendrites in Drosophila. Neuron 81:544-60. PMCID: PMC3995171. [PubMedCentral]

  • Yuan, Q., Song Y., Yang, C.H, Jan, L.Y., and Jan, Y.N. (2014). Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila, Nature Neurosci. 17:81-8. PMCID: PMC3995170. [PubMedCentral]

2013

  • Isacoff, E.Y., Jan, L.Y., Minor, D.L. Jr. (2013) Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron 80:658-74. PMCID: PMC3867263. [PubMedCentral]

  • Kim, W.J., Jan, L.Y., and Jan, Y.N. (2013). A PDF/NPF Neuropeptide Signaling Circuitry of Male Drosophila melanogaster Controls Rival-Induced Prolonged Mating. Neuron 80:1190-205. PMCID: PMC3867312. [PubMedCentral]

  • Wong, X. M., Younger, S., Peters, C.J., Jan, Y.N., and Jan, L.Y. (2013). Subdued, a TMEM16 family Ca2+-activated Cl- channel in Drosophila melanogaster with an unexpected role in host defense. eLife 2:e00862. PMCID: PMC3814000. [PubMedCentral]

  • Sun, Y., Dong, Z., Jin, T., Ang, K.H., Huang, M., Haston, K.M., Peng, J., Zhong, T.P., Finkbeiner, S., Weiss, W.A., Arkin, M.R., Jan, L.Y., and Guo, S. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. eLife 2:e00508. PMCID: PMC3771564 [PubMedCentral]

  • Han, T.W., and Jan, L.Y. (2013) Making antisense of pain. Nat Neurosci 16:986-7. PMID: 23887131. [PubMedCentral]

  • Zhang, W., Yan, Z., Jan, L.Y., and Jan, Y.N. (2013) Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. PNAS USA 110:13612-7. PMCID: PMC3746866. [PubMedCentral]

  • Huang, F., Wang, X., Ostertag, E.M., Nuwal, T., Huang, B., Jan, Y.N., Basbaum, A.I., and Jan, L.Y. (2013) TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 16:1284-90. PMCID: PMC4034143. [PubMedCentral]

  • Tien, J., Lee, H.Y., Minor, D.L. Jr., Jan, Y.N., and Jan, L.Y. (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). PNAS USA 110:6352-7. PMCID: PMC3631655. [PubMedCentral]

  • Thayer, D.A., Jan, Y.N., Jan, L.Y. (2013) Increased neuronal activity fragments the Golgi complex. PNAS USA 110:1482-1487. PMCID: PMC3557034. [PubMedCentral]

  • Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L.E., Meltzer, S., Jan, L.Y., and Jan, Y.N. (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493:221-5. PMCID: PMC3917554. [PubMedCentral]

2012

  • Ori-McKenney, K.M., Jan, L.Y., and Jan, YN. (2012) Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron 76:921-30. PMCID: PMC3523279 [PubMedCentral]

  • Fieni, F., Bae Lee, S., Jan, Y.N., and Kirichok, Y. (2012) Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 3:1317. PMCID: PMC3818247. [PubMedCentral]

  • Yang, H., Kim, A., David, T., Palmer, D., Jin, T., Tien, J., Huang, F., Cheng, T., Coughlin, S.R., Jan, Y.N., and Jan, L.Y. (2012) TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation. Cell 151:111-22. PMCID: PMC3582364. [PubMedCentral]

  • Huang, F., Zhang, H., Wu, M., Yang, H., Kudo, M., Peters, C.J., Woodruff, P.G., Solberg, O.D., Donne, M.L., Huang, X., Sheppard, D., Fahy, J.V., Wolters, P.J., Hogan, B.L., Finkbeiner, W.E., Li, M., Jan, Y.N., Jan, L.Y., Rock, J.R. (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. PNAS USA 109:16354-9. PMCID: PMC3479591. [PubMedCentral]

  • Huang, X., Dubuc, A.M., Hashizume, R., Berg, J., He, Y., Wang, J., Chiang, C., Cooper, M.K., Northcott, P.A., Taylor, M.D., Barnes, M.J., Tihan, T., Chen, J., Hackett, C.S., Weiss, W.A., James, C.D., Rowitch, D.H., Shuman, M.A., Jan, Y.N., and Jan, L.Y. (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 26:1780-96. PMCID: PMC3426758. [PubMedCentral]

  • Yang, S.B., Tien, A.C., Boddupalli, G., Xu, A.W., Jan, Y.N., and Jan, L.Y. (2012) Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons. Neuron 75: 425-436. PMCID: PMC3467009. [PubMedCentral]

  • Yang, S.B., Lee, H.Y., Young, D.M., Tien, A.C., Rowson-Baldwin, A., Shu, Y.Y., Jan, Y.N., Jan, L.Y. (2012) Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med 90:575-85. PMCID: PMC3354320. [PubMedCentral]

  • Song, Y., Ori-McKenney, K.M., Zheng, Y., Han, C., Jan, L.Y., and Jan, Y.N. (2012). Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26:1612-1625. PMCID: PMC3404388. [PDF]

  • Berg, J., Yang, H., and Jan, L.Y. (2012) Ca2+-activated Cl-channels at a glance. J. Cell Sci. 125:1367-1371. PMCID: PMC3336373. [PDF]

  • Jan, Y.N. (2012) Yoshiki Hotta's influence. J Neurogenet. 26:3-4. PMID:22263807. [PDF]

  • Kim, W.J., Jan, L.Y., and Jan, Y.N. (2012) Contribution of Visual and Circadian Neural circuits to Memory for Prolonged Mating induced by Rivals. Nature Neurosci. 15:876–883. PMCID: PMC3417086. [PubMedCentral]

  • Huang, W.C, Xiao, S., Huang, F., Harfe, B.D., Jan, Y.N., and Jan, L.Y. (2012) Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons. Neuron 74:179-192. PMID: PMC3329964. [PDF]

  • Lee, H.Y., and Jan, L.Y. (2012) Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels. Curr Opin Neurobiol. 22:887-894. PMID: 22483378. [PubMedCentral]

  • Jan, L.Y., and Jan, Y.N. (2012) Voltage-gated potassium channels and the diversity of electrical signalling. J Physiol. 590:2591-9. PMCID: PMC3424718. [PubMedCentral]

  • Ge, W.P., Miyawaki, A., Gage, F.H., Jan, Y.N., and Jan, L.Y. (2012) Local generation of glia is a major astrocyte source in postnatal cortex. Nature 484:376-380. PMCID: PMC3777276. [PubMedCentral]

  • Yang, S.B., Mclemore, K.D.,Tasic, B., Luo, L., Jan, Y.N., and Jan, L.Y. (2012) Kv1.1-dependent Control of Hippocampal Neuron Number as Revealed by Mosaic Analysis with Double Markers (MADM). J Physiol. 590:2645-58. PMCID: PMC3424722. [PubMedCentral]

  • Ultanir, S.K., Hertz, N.T., Li, G., Ge, W.P., Burlingame, A.L., Pleasure, S.J., Shokat, K.M., Jan, L.Y., and Jan, Y.N. (2012) Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development. Neuron 73:1127-1142. PMCID: PMC3333840. [PDF]

  • Han, C., Wang, D., Soba, P., Zhu, S., Lin, X., Jan, L.Y., and Jan, Y.N. (2012) Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron 73:64-78. PMCID: PMC3269260. [PubMedCentral]

  • Huang, F., Wong, X., and Jan, L.Y. (2012) International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels. Pharmacol Rev 64:1-15. PMCID: PMC3250081. [PDF]

2011

  • Zhu, S., Barshow, S., Wildonger, J., Jan, L.Y., and Jan, Y.N. (2011). Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains. PNAS USA 108: 20615-20. PMCID: PMC3251047 [PubMedCentral]

  • Lee, H.Y., Ge, W.P., Huang, W., He, Y., Wang, G.X., Rowson-Baldwin, A., Smith, S.J., Jan, Y.N., and Jan, L.Y. (2011) Bidirectional Regulation of Dendritic voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein. Neuron 72:630-642. PMCID: PMC3433402. [PDF]

  • Lee, S.B., Bagley, J.A., Lee, H.Y., Jan, L.Y., and Jan, Y.N. (2011) Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila. Proc Natl Acad Sci USA 108:16795-16800. PMCID: PMC3189048. [PDF]

  • Yuan, Q., Xiang, Y., Yan, Z., Han, C., Jan, L.Y., and Jan, Y.N. (2011) Light-induced structural and functional plasticity in Drosophila larval visual system. Science 333:1458-62. PMCID: PMC4114502. [PDF]

  • Rumpf, S., Lee, S.B., Jan, L.Y. and Jan, Y.N. (2011) Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development 138:1153-1160. PMCID: PMC3042870. [PDF]

  • Ye, B., Kim, J.H., Yang, L.M., McLachlan, I., Younger, S., Jan, L.Y. and Jan, Y.N. (2011) Differential regulation of dendritic and axonal development by the novel Kruppel-like factor Dar1. J. Neurosci. 31:3309-3319. PMCID: PMC3086283. [PDF]

  • Ouyang, Y., Petritsch, C., Wen, H., Jan, L., Jan, Y.N., and Lu, B. (2011) Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development 138:2185-96. PMCID: PMC3091490. [PubMedCentral]

  • Han, C., Jan, L.Y., and Jan, Y.N. (2011) Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A. 108:9673-8. PMCID: PMC3111288. [PubMedCentral]

2010

  • Xiang, Y., Yuan, Q., Vogt, N., Looger, L.L., Jan, L.Y., and Jan, Y.N. (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468:921-926. PMCID: PMC3026603. [PDF]

  • Thayer, D.A., and Jan, L.Y. (2010) Mechanisms of distribution and targeting of neuronal ion channels. Curr Opin Drug Discov Devel. 13:559-567. PMID: 20812147. [PubMedCentral]

  • Cheng, L.E., Song, W., Looger, L.L., Jan, L.Y., and Jan, Y.N. (2010) The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion. Neuron. 67:373-380. PMCID: PMC2933178. [PDF]

  • Young, DM., Schenk, AK., Yang, SB., Jan, YN., Jan, LY. (2010) Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc Natl Acad Sci USA. 107:11074-11079. PMCID: PMC2890736 [PubMedCentral]

  • Zhou, W., Jan, LY. (2010) A Twist on Potassium Channel Gating. Cell 141(6):920-22. PMID: 20550927. [PDF]

  • Jan, Y.N., and Jan, L.Y. (2010) Branching out: mechanisms of dendritic arborization. Nat. Rev. Neurosci. 11:316-328. PMCID: PMC3079328. [PDF]

2009

  • Yang, C., Rumpf, S., Xiang, Y., Gordon, M.D., Song, W., Jan, LY., Jan, YN. (2009) Control of the postmating behavioral switch in Dropsophila females by internal sensory neurons. Neuron 61 (4):519-526. PMCID: PMC2748846 [PubMed]

  • Xiao, S.H., and Jan, L.Y. (2009) A gate keeper for axonal transport. Cell 136(6):996-998. PMID: 19303842 [PubMed]

  • Parrish, J.Z., Xu, P., Kim, K.C., Jan, L.Y., and Jan, Y.N. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in Drosophila sensory neurons. Neuron 63:788-802.  PMCID: PMC2772869 . [PubMed]

  • Lee, H.H., Jan, L.Y., and Jan, Y.N. (2009) Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci, USA. 106:6363-8. PMCID: PMC2661847 [PubMedCentral]

  • Kim, M.D., Wen, Y., Jan, Y.N. (2009) Patterning and organization of motor neuron dendrites in the Drosophila larva. Dev Biol. 336:213-21. PMCID: PMC2785125 [PubMedCentral]

  • Huang, F., Rock, J.R., Harfe, B.D., Cheng, T., Huang, X., Jan, Y.N., Jan, L.Y. (2009) Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci USA 106:21413-8. PMCID: PMC2781737 [PubMedCentral]

  • Ge, WP., Zhou, W., Luo, Q., Jan, LY., Jan, YN. (2009) Dividing glial cells maintain diffentiated properties including complex morphology and functional synapses. Proc Natl Acad Sci USA. 106(1):328-33. PMCID: PMC2610014 [PubMedCentral]

  • Chung, HJ., Qian, X., Ehlers, M., Jan, YN., Jan, LY. (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci USA. 106(2):629-34. PMCID: 2613039 [PubMedCentral]

  • Chung, HJ., Ge, WP., Qian, X., Wiser, O., Jan, YN., Jan, LY. (2009) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term protentiation. Proc Natl Acad Sci USA. 106(2):635-40. PMCID: PMC2613041 [PubMedCentral]

  • Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.H. (2009) Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 63:189-202. PMCID: PMC2736606 [PubMedCentral]

2008

  • Sokol, S.N., Xu, P., Jan, Y.N., and Ambros, V. (2008). Dropsophila let-7 micro RNA is required for remodeling of the neuromusculature during metamorphosis. Genes & Dev. 22:1591-1596. PMCID: PMC2428057 [PubMedCentral]

  • Schroeder, B.C., Cheng, T., Jan, Y.N., Jan, L.Y. (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134 (6): 1019-1029. PMCID: PMC2651354 [PubMedCentral]

  • Yang, C.H., Belawat, P., Hafen, E., Jan, L.Y. and Jan, Y.N. (2008). Drosophila egg-layng site selection as a system to study simple decision-making processes. Science 319:1679-1683. PMCID: PMC2581776 [PubMedCentral]

  • Wildonger, J., Jan, L.Y., Jan, Y.N. (2008) The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Genes Dev. 22: 2447-2453. PMCID: PMC2749676 [PubMed]

  • Jan, Y.N. and Jan., L. (2008). Retrospective: Seymour Benzer (1921-2007). Science 319:45. PMID: 18174427 [PubMed]

  • Yang, S.B., and Jan, L.Y. (2008) Thrilling moment of an inhibitory channel. Neuron 58:823-824. PMID: 18579071 [PubMed]

  • Chi, N.C., Shaw, R.M., De Val, S., Kang, G., Jan, L.Y., Black, B.L., and Stainier, D.Y.R. (2008). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & Development 22:734-739. PMCID: PMC2275426 [PubMedCentral]

  • Chi, N.C., Shaw, R.M., Jungblut, B., Ferrer, T., Aarnaout, R., Scott, I., Beis, D., Xiaao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M. and Stainier, D.Y.R. (2008). Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biology 13:6(5): e109. PMCID: PMC2430899 [PubMedCentral]

  • Zheng, Y, Wildonger, J., Ye, B., Zhang, Y., Kita, A., Younger, S.H., Zimmerman, S., Jan, L.Y., Jan, Y.N.(2008) Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol. 10:1172-1180. PMCID: PMC2588425 [PubMed]

  • Huang, J., Zou, W., Watson, A., Jan, Y.N., Hong, Y. (2008) Efficient Ends-Out GeneTargeting In Drosophilia. Genetics 180: 703-707. PMCID: PMC2535722 [PubMedCentral]

 

 

2007

  • Ye, B., Zhang, Y., Song, W., Younger, S.H., Jan, L.Y., and Jan, Y.N. (2007). Growing dendrites and axons differ in their reliance on the secretory pathway. Cell 130:717-729. PMCID: PMC2020851 [PubMedCentral]

  • Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S.J., Yu, H.H., Lee, T., Jan, L.Y., and Jan, Y.N. (2007). Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron 54:403-416. PMCID: PMC1963441  [PubMedCentral]

  • Parrish, J.Z., Emoto, K., Kim, M.D., and Jan, Y.N. (2007). Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu. Rev. Neurosci. 30:399-423. PMID: 17378766 [PubMed]

  • Parrish, J.Z., Emoto, K., Jan, L.Y., and Jan, Y.N. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21:956-972. PMCID: PMC1847713  [PubMedCentral]

  • Song, W., Onishi, M., Jan, L.Y., and Jan, Y.N. (2007). Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Proc Natl Acad Sci U S A. 104:5199-5204. PMCID: PMC1820883 [PubMedCentral]

  • Grueber, W.B., Ye, B., Yang, C.H., Younger, S., Borden, K., Jan, L.Y., and Jan, Y.N. (2007). Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 134:55-64. PMID: 17164414  [PubMed] Final Version Available Free

  • Koo, B.K., Yoon, M.J., Yoon, K.J., Im, S.K., Kim, Y.Y., Kim, C.H., Suh, P.G., Jan, Y.N., and Kong, Y.Y. (2007). An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS ONE. 2:e1221. PMCID: PMC2082076 [PubMedCentral]

  • Rasin, M.R., Gazula, V.R., Breunig, J.J., Kwan, K.Y., Johnson, M.B., Liu-Chen, S., Li, H.S., Jan, L.Y., Jan, Y.N., Rakic, P., and Sestan, N. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat. Neurosci. 10:819-827. PMID: 17589506 [PubMed]

  • Grabe, M., Lai, H.C., Jain, M., Jan, Y.N., and Jan, L.Y. (2007).  Structure prediction for the down state of a potassium channel voltage sensor. Nature 445, 550-553. PMID: 17187053 [PubMed]

  • Gong, Q., Weide, M., Huntsman, C., Xu, Z., Jan, L.Y., Ma D. (2007). Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling.  J. Biol. Chem. 17:13087-13097.  [PubMed] Final Version Available Free

  • Haass, F.A., Jonikas, M., Walter, P., Weissman, J.S., Jan, Y.N., Jan, L.Y., and Schuldiner, M. (2007). Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc. Natl. Acad. Sci. USA 104:18079-18084. PMCID: PMC2084299 [PubMedCentral]

  • Chang, W., Tu, C., Cheng, Z., Rodriguez, L., Chen, T.H., Gassmann, M., Bettler, B., Margeta, M., Jan, L.Y., and Shoback, D. (2007). Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J. Biol. Chem. 282:25030-25040. PMID: 17591780 [PubMed] Final Version Available Free

  • Shaw, R., Fay, A., Puthenveedu, M.A., von Zastrow, M., Jan, Y.N., and Jan, L.Y. (2007). Microtubule plus end tracking proteins target gap junctions directly from the cell interior to adheren junctions. Cell 128:547-560. PMCID: PMC1955433  [PubMedCentral]

 

 

2006

  • Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Genes Dev. 20:2806-2819. PMCID: PMC1619948 [PubMedCentral]

  • Ye, B., and Jan, Y.N. (2006). Visualizing the breaking of symmetry. Dev. Cell 10:411-412. PMID: 16580986  [PubMed]

  • Emoto, K., Parrish, J.Z., Jan, L.Y., and Jan, Y.N. (2006). The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 443:210-213. PMID: 16906135  [PubMed]

  • Kuo, C.T., Zhu, S., Younger, S, Jan, L.Y., and Jan, Y.N. (2006). Identification of e2/e3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron 51:283-290. PMID: 16880123 [PubMed]

  • Sweeney, N.T., Brenman, J.E., Jan, Y.N., and Gao, F.B. (2006). The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. Curr. Biol. 16:1006-1011. PMID: 16713958 [PubMed]

  • Parrish, J.Z., Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 20:820-835. PMCID: PMC1472285  [PubMedCentral]

  • Yu, F., Kuo, C.T., and Jan, Y.N. (2006). Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron 51:13-20. PMID: 16815328 [PubMed]

  • Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., and Jan, Y.N.  (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127:1253-1264. PMCID: PMC1876765 [PubMedCentral]

  • Ja, W.W., Wiser, O., Austin, R.J., Jan, L.Y., and Roberts, R.W., (2006). Turning G proteins on and off using peptide ligands. ACS Chem. Biol. 1:570-574. PMID: 17168552 [PubMed]

  • Raab-Graham, K.F., Haddick, P.C., Jan, Y.N., and Jan, L.Y. (2006). Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314:144-148. PMID: 17023663 [PubMed]  

  • Lai, H.C., and Jan, L.Y. (2006). The distribution and targeting of neuronal voltage-gated ion channels. Nat. Rev. Neurosci. 7:548-562. PMID: 16791144 PMID: 16791144  [PubMed]

  • Chung, H.J., Jan, Y.N., and Jan, L.Y. (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc. Natl. Acad. Sci. USA 103:8870-8875. PMCID: PMC1472242 [PubMedCentral]

  • Grabe, M., Bichet, D., Qian, X., Jan, Y.N., and Jan, L.Y. (2006). K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc. Natl. Acad. Sci. USA 103:14361-14366. PMCID: PMC1570128  [PubMedCentral]

  • Bichet, D., Grabe, M., Jan, Y.N., and Jan, L.Y. (2006). Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc. Natl. Acad. Sci. USA 103:14355-14360. PMCID: PMC1570129 [PubMedCentral]

  • Wiser, O., Qian, X., Ehlers, M., Ja, W.W., Roberts, R.W., Reuveny, E., Jan, Y.N., and Jan, L.Y. (2006). Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron 50:561-573. PMID: 16701207 [PubMed]

  • Gu, C., Zhou, W., Puthenveedu, M.A., Xu, M., Jan, Y.N., and Jan, L.Y. (2006). The Microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron 52:803-816. PMID: 17145502  [PubMed]

  • Chung, H.J., and Jan L.Y. (2006). Channeling to the nucleus. Neuron 52:937-940. PMID: 17178398 [PubMed]

  • Fay, A.J., Qian, X., Jan, Y.N., and Jan, L.Y. (2006). SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc. Natl. Acad. Sci. U.S.A. 103:17548-17553. PMCID: PMC1634413 [PubMedCentral]

  • Ye, B., Zhang, Y.W., Jan, L.Y., and Jan, Y.N. (2006). The secretory pathway and neuron polarization. J. Neurosci. 26:10631-10632. PMID: 17050701 [PubMed] Final Version Available Free

 

 

2005

  • Kuo, C.T., Jan, L.Y., and Jan, Y.N. (2005). Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc. Natl. Acad. Sci. USA 102:15230-15235.  [PubMedCentral]

  • Grueber, W.B., Yang, C.H., Ye, B., and Jan, Y.N. (2005). The development of neuronal morphology in insects. Curr Biol. 15:R730-R738.  [PubMed]

  • He, Y., Emoto, K., Fang, X., Ren, N., Tian, X., Jan, Y.N., and Adler, P.N. (2005). Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases. Mol. Biol. Cell. 16:4139-4152.  [PubMed]

  • Goldstein, A.Y.N., Jan, Y.N., and Luo, L. (2005). Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 102:3834-3839.  [PubMedCentral]

  • He, Y., Fang, X., Emoto, K., Jan, Y.N., and Adler, P.N. (2005). The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development. Mol. Biol. Cell 16:689-700.  [PubMedCentral]

  • Ye, B., and Jan, Y.N. (2005). The cadherin superfamily and dendrite development. TRENDS Cell Biol. 15:64-67.  [PubMed]

  • Huang, E.J., Li, H.h., Tang, A.A., Wiggins, A.K., Neve, R.L., Zhong, W., Jan, L.Y., and Jan, Y.N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19:138-151.  [PDF]

  • Kuo, C.T., and Jan, Y.N. (2005). The hand that rocks the spindle. Nat. Cell Biol. 7:858-859.  [PubMed]

  • Roegiers, F., Jan, L.Y., and Jan, Y.N. (2005). Regulation of membrane localization of sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol. Biol. Cell. 16:3480-3487.  [PubMedCentral]

  • Lai, E.C., Roegiers, F., Qin, X., Jan, Y.N., and Rubin, G.M. (2005). The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132:2319-2332.  [PubMed]

  • Anderson, A.C., Kitchens, E.A., Chan, S.W., Hill, C. St., Jan, Y.N., Zhong, W., and Robey, E.A. (2005). The Notch regulator numb links the Notch and TCR signaling pathways. J. Immunol. 174:890-897.  [PubMed]

  • Jan, L.Y., and Siegelbaum, S.A. (2005). Signaling mechanisms. Curr. Opin. Neurobiol. 15:253-256. [PDF]

  • Surti, T.S., Huang, L., Jan, Y.N., Jan, L.Y., and Cooper, E.C. (2005). Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc. Natl. Acad. Sci. USA 102:17828-17833.  [PubMedCentral]  

  • Lai, H.C., Grabe, M., Jan, Y.N., and Jan, L.Y. (2005). The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron 47:395-406. PMID: 16055063.  [PubMed]

  • Ionescu-Zanetti, C., Shaw, R.M., Seo, J., Jan, Y.N., Jan, L.Y., and Lee, L.P. (2005). Mammalian electrophysiology on a microfluidic platform. Proc. Natl. Acad. Sci. U.S.A. 102:9112-9117.  [PubMedCentral]

  • Surti, T.S., and Jan, L.Y. (2005). A potassium channel, the M-channel, as a therapeutic target. Curr. Opin. Investig. Drugs 6:704-711.  [PubMed]

  • Kubo, Y., Adelman, J.P., Clapham, D.E., Jan, L.Y., Karschin, A., Kurachi, Y., Lazdunski, M., Nichols, C.G., Seino, S., and Vandenberg, C.A. (2005). International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol. Rev. 57:509-526.   [PubMed]

  • Cohen, B.E., Pralle, A., Yao, X-J, Swaminath, G., Gandhi, C., Jan, Y.N., Kobilka, B.K., Isacoff, E.Y., and Jan, L.Y. (2005).  A fluorescent probe designed for studying protein conformational change.  Proc. Natl. Acad. Sci. USA 102:965-970.  [PubMedCentral]

  • Huang, C.S., Shi, S.-H., Ule, J., Ruggiu, M., Barker, L.A., Darnell, R.B., Jan, Y.N., and Jan, L.Y. (2005). Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell 123:105-118. PMID: 16213216 [PubMed]

 

 

2004

  • Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr. Biol. 14:2025-2032.  [PubMed]

  • Shi, S.-H., Cox, D.N., Wang, D., Jan, L.Y., and Jan, Y.N. (2004). Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc. Natl. Acad. Sci. USA 101:13341-13345.  [PubMed]

  • Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc. Natl. Acad. Sci. USA 101:13346-13351.  [PubMed]

  • Ye, B., Petritsch, C., Clark, I.E., Gavis, E.R., Jan, L.Y., and Jan, Y.N. (2004). nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Current Biology, 14:314-321.  [PubMed]

  • Moore, A.W., Roegiers, F., Jan, L.Y., and Jan, Y.N. (2004). Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. Genes Dev 18:623-628.  [PubMedCentral]

  • Grueber, W.B., and Jan, Y.N. (2004). Dendritic development: lessons from Drosophila and related branches. Curr. Opin. Neurobiol. 14:74-82.  [PubMed]

  • Roegiers, F., and Jan, Y.N. (2004). Asymmetric cell division. Curr. Opin. Cell Biol. 16:195-205.  [PubMed]

  • McCarroll, S.A., Murphy, C.T., Zou, S., Pletcher, S.D., Chin, C.-S., Jan, Y.N., Kenyon, C., Bargmann, C.I., and Li, H. (2004). Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics 36:197-204.  [PubMed]

  • Grabe, M., Lecar, H., Jan, Y.N., and Jan, L.Y. (2004). A quantitative assessment of models for voltage-dependent gating of ion channels. Proc. Natl. Acad. Sci. USA 101:17640-17645.  [PubMedCentral]

  • Lin, Y.-F., Raab-Graham, K., Jan, Y.N., and Jan, L.Y. (2004). NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101:7799-7804.  [PubMedCentral]

  • Bichet, D., Lin, Y.-F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N., and Jan, L.Y. (2004). Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci USA 101:4441-4446.  [PDF]

  • Emoto, K., He, Y., Ye, B., Grueber, W.B., Adler, P.N., Jan, L.Y., and Jan, Y.N. (2004). Control of dendritic branching and tiling by the Tricornered-kinase/Flurry signaling pathway in Drosophila sensory neurons. Cell 119: 245-256. PMID: 15479641 [PubMed]

 

 

2003

  • Jan, Y.N., and Jan, L.Y. (2003). The control of dendrite development. Neuron 40:229-242.  [PubMed]

  • Rothenberg, M.E., Rogers, S.L., Vale, R.D., Jan, L.Y., and Jan, Y.N. (2003).  Drosophila Pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron 39:779-791.  [PubMed]

  • Grueber, W.B.*, Ye, B.*, Moore, A.W., Jan L.Y., and Jan, Y.N. (2003). Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr. Biol. 13:618-626. (* = equal contribution).  [PubMed]

  • Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2003). Different levels of the homeodomain protein Cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell 112:805-818. PMID: 12654247 [PubMed]

  • Rothenberg, M., and Jan, Y.N. (2003). The hippo hypothesis. Nature 425:469- 470.  [PubMed]

  • Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003)  Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.  Cell 112:63-75. PMID: 12526794 [PubMed]

  • Li, H.-S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40:1105-1118. PMID: 14687546.  [PubMed]

  • Justice, N.J., Roegiers, F.R., Jan, L.Y., and Jan, Y.N. (2003). Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr. Biol. 13:778-783.  [PubMed]

  • Justice, N.J., and Jan, Y.N. (2003). A lethal giant kinase in cell polarity. Nat. Cell Biol. 5:273-274.  [PubMed]

  • Petritsch, C., Tavosanis, G., Turck, C.W., Jan, L.Y., and Jan, Y.N. (2003).  The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.  Dev. Cell 4, 273-281.  [PubMed]

  • Abdelilah-Seyfried, S., Cox, D.N., and Jan, Y.N. (2003).  Bazooka is a permissive factor for the invasive behavior of Discs large tumor cells in Drosophila ovarian follicular epithelia.  Development 130:1927-1935.  [PubMed]

  • Jan, Y.N. (2003). Q & A. Curr. Biol. 13:R378-R379  [PubMed]

  • Gutman, G.A., Chandy, K.G., Adelman, J.P., Aiyar, J., Bayliss, D.A., Clapham, D.E., Covarriubias, M., Desir, G.V., Furuichi, K., Ganetzky, B., Garcia, M.L., Grissmer, S., Jan, L.Y., Karschin, A., Kim, D., Kuperschmidt, S., Kurachi, Y., Lazdunski, M., Lesage, F., Lester, H.A., McKinnon, D., Nichols, C.G., O'Kelly, I., Robbins, J., Robertson, G.A., Rudy, B., Sanguinetti. M,, Seino, S., Stuehmer, W., Tamkun, M.M., Vandenberg, C.A., Wei, A., Wulff, H., and Wymore, R.S. (2003). International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 55:583-586.  [PubMed]

  • Cohen, B., Grabe, M., and Jan, L.Y. (2003). Answers and questions from the KvAP structures. Neuron 39:395-400.  [PubMed]

  • Cooper, E.C., and Jan, L.Y. (2003). M-channels: neurological diseases, neuromodulation, and drug development. Arch. Neurol. 60:496-500.  [PubMed]

  • Bichet, D., Haass, F.A., and Jan, L.Y. (2003). Merging functional studies with structures of inward-rectifier K+ channels. Nature Reviews Neuroscience 4:957-967.  [PubMed]

  • Hu, K., Huang, C.S., Jan, Y.N. and Jan, L.Y. (2003) ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C.  Neuron 38:417-432.  [PubMed]

  • Mitrovic, I., Margeta-Mitrovic, M., Bade, S., Stoffel, M., Jan, L.Y., and Basbaum, A.I. (2003) Contribution of GIRK2-mediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences.  Proc. Natl. Acad. Sci USA 100:271-276.  PMCID: PMC140949 [PubMedCentral]

  • Gu, C., Jan, Y. N., and Jan, L. Y. (2003). A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channel. Science 301:646-649.   PMID: 12893943 [PubMed]

  • Pei,L., Wiser, O., Slavin, A., Mu, D., Powers, S., Jan, L.Y., and Hoey, T. (2003). Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proc. Natl. Acad. Sci. USA 100:7803-7807. [PDF]

  • Mu, D., Chen, L., Zhang, X., See, L.-H., Koch, C.M., Yen, C., Tong, J.J., Spiegel, L., Nguyen, K.C.Q., Servoss, A., Peng, Y., Pei, L., Marks, J.R., Lowe, S., Hoey, T., Jan, L.Y., McCombie, W.R., Wigler, M.H., and Powers, S. (2003).  Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.  Cancer Cell 3:297-302.  [PubMed]

  • Hong, Y., Ackerman, L., Jan, L.Y., and Jan, Y.N. (2003). Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture. Proc. Natl. Acad. Sci. USA 100:12712-12717. [PubMed]

  • Sun, Y., Kanekar, S.L., Vetter, M.L., Gorski, S., Jan, Y.N., Glaser, T., and Brown, N.L. (2003). Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evolution & Development 5:532-541. [PubMed]

 

 

2002

  • Moore, A.W., Jan, L.Y., and Jan, Y.N. (2002). hamlet, a binary genetic switch between single and multiple dendrite neuron morphology. Science 297: 1355-1358. PMID: 12193790 [PubMed]

  • Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2002). Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development 129:2867-2878.  [PDF]

  • Rothenberg, M., and Jan, Y. (2002). salvador-The persistence of proliferation. Cancer Cell 2:171-173.   [PubMed]

  • Justice, N.J., and Jan, Y.N. (2002).  Variations on the Notch pathway in neural development  Curr. Opin. Neurobiol., 12: 64-70  [PubMed]

  • Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N., and Zhong, W. (2002).  Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.  Nature 419:929-934.  [PubMed]

  • Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002).  Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.  Development 129:4843-4853.  [PDF]

  • Donovan, J., Kordylewska, A., Jan, Y., and Utset, M. (2002).  Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.  Curr. Biol. 12:1605-1610.  [PubMed]

  • Ma, D., Zerangue, N. Raab-Graham, K., Fried, S.R., Jan, Y.N., and Jan, L.Y. (2002).  Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.  Neuron 33:715-729.  PMID: 11879649[PubMed]

  • Ma, D., and Jan, L.Y. (2002). ER transport signals and trafficking of potassium channels and receptors. Curr. Opin. Neurobiol. 12:287-292.  [PubMed]

  • Cohen, B.E., McAnaney, T.B., Park, E.S., Jan, Y.N., Boxer, S.G., and Jan, L.Y. (2002). Probing protein electrostatics with a synthetic fluorescent amino acid. Science. 296:1700-1703.  [PubMed]

 

 

2001

  • Brenman, J.E., Gao, F-B., Jan, L.Y., and Jan, Y.N. (2001). Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev. Cell 1:667-677.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (2001). Dendrites. Genes Dev. 15:2627-2641.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (2001).  Asymmetric cell division in the Drosophila nervous system.  Nature Revs. Neurosci. 2:772-779.  [PubMed]

  • Hong, Y., Stronach, B., Perrimon, N., Jan, L.Y., and Jan, Y.N. (2001).  Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.  Nature 414:634-638.  [PubMed]

  • Roegiers, F., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (2001).  Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.  Proc. Natl. Acad. Sci USA 98:14469-14474.  [PDF]

  • Sun, T.-Q., Lu, B., Feng, J.-J., Reinhard, C., Jan, Y.N., Frantl, W.J., and Williams, L.T. (2001).  PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signaling.  Nature Cell Biol. 3:628-636.  [PubMed]

  • Lu, B., Roegiers, F., Jan, L.Y., and Jan, Y.N. (2001).  Adherens junctions inhibit asymmetric division in the Drosophila epithelium.  Nature 409:522-525.  [PubMed]

  • Roegiers, F., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (2001).  Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.  Nature Cell Biol. 3:58-67.  [PubMed]

  • Cox, D.N., Abdelilah Seyfried, S., Jan, L.Y., and Jan, Y.N. (2001).  Bazooka and atypical protein kinase C are required to regulate oocyte differenation in the Drosophila ovary.  Proc. Natl. Acad. Sci USA 98:14475-14480.  [PDF]

  • Cox, D.N., Lu, B.-W., Sun, T.-Q., Williams, L.T., and Jan, Y.N. (2001).  Drosophila par-1 is required for oocyte differentiation and microtubule organization.  Curr. Biol. 11:75-87.  [PubMed]

  • Horne-Badovinac, S., Lin, D., Waldron, S., Schwarz, M., Mbamalu, G., Pawson, T., Jan, Y.-N., Stainier, D.Y.R., and Abdelilah-Seyfried, S. (2001).  Positional cloning of heart and soul reveals multiple roles for PKCλ in zebrafish organogenesis.  Curr. Biol. 11:1492-1502.  [PubMed]

  • Ruan, Y., Tecott, L., Jiang, M.-M., Jan, L.Y., and Jan, Y.N. (2001).  Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.  Proc. Natl. Acad. Sci. USA 98: 9907-9912.  [PDF]

  • Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2001).  Function of GB1 and GB2 subunits in G protein coupling of GABAB receptors. Proc. Natl. Acad. Sci USA 98:14649-14654.  [PDF]

  • Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2001).  Ligand-induced signal transduction within heterodimeric GABAB receptor. Proc. Natl. Acad. Sci. USA 98:14643-14648.  [PDF]

  • Yi, B.A., Minor, D.L., Jr., Lin, Y.-F., Jan, Y.N., and Jan, L.Y. (2001).  Controlling potassium channel activities: interplay between the membrane and intracellular factors.  Proc. Natl. Acad. Sci. USA 98:11016-11023.  [PubMed]

  • Cooper, E.C., Harrington, E., Jan, Y.N., and Jan, L.Y. (2001).  M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.  J. Neurosci. 21:9529-9540.  [PDF]

  • Lu, T., Ting, A.Y., Mainland, J., Jan, L.Y., Schultz, P.G., and Yang, J. (2001). Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter. Nat. Neurosci. 4:239-246  [PubMed]

  • Yi, B.A., Lin, Y.F., Jan, Y.N.. and Jan, L.Y. (2001).  Yeast screen for constitutively active mutant G protein-activated potassium channels.  Neuron 29:657-667. PMID: 11301025.  [PubMed]

  • Ma, D., Zerangue, N., Lin, Y.-F., Collins, A., Yu, M., Jan, Y.N., and Jan, L.J.  (2001). Role of ER export signals in controlling surface potassium channel numbers.  Science 291:316-319.  PMID: 11209084 [PubMed]

  • Zerangue, N., Malan, M.J., Fried, S.R., Dazin, P.F., Jan, Y.N., Jan, L.Y., and Schwappach, B. (2001).  Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.  Proc. Natl. Acad. Sci. USA 98: 2431-2436.  [PDF]

 

 

2000

  • Abdelilah-Seyfried, S., Chan, Y.-M., Zeng, C., Justice, N.J., Younger-Shepherd, S., Sharp, L.E., Barbel, S., Meadows, S.A., Jan, L.Y., and Jan, Y.N. (2000). A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155:733-752.  [PDF]

  • Gao, F.-B., Kohwi, M., Brenman, J.E., Jan, L.Y., and Jan, Y.N. (2000). Control of dendritic field formation in Drosophila: The roles of flamingo and competition between homologous neurons. Neuron 28:91-101.  [PubMed]

  • Hassan, B.A., Bermingham, N.A., He, Y., Sun, Y., Jan, Y.N., Zoghbi, H.Y., and Bellen, H.J. (2000) Atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25: 549-561.  [PubMed]

  • Sun, Y., Jan, L.Y., and Jan, Y.N. (2000).  Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.  Proc. Natl. Acad. Sci. 97:6815-6819.  [PDF]

  • Lu, B., Jan, L.Y., and Jan, Y.N. (2000).  Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry.  Annu. Rev. Neurosci. 23:531-556.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (2000).  Polarity in cell division: What frames they fearful asymmetry?  Cell 100:599-602.  [PubMed]

  • Roegiers, F., and Jan, Y.N. (2000).  Staufen: a common component of mRNA transport in oocytes and neurons?  Trends Cell Biol. 10: 220-224.  [PubMed]

  • Zou, S., Meadows, S., Sharp, L., Jan, L.Y., and Jan, Y.N. (2000).  Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.  Proc. Natl. Acad. Sci. USA 97: 13726-13731.  [PDF]

  • Moore, A.W., Barbel, S., Jan, L.Y., and Jan, Y.N. (2000).  A genomewide survey of basic helix-loop-helix factors in Drosophila.  Proc. Natl. Acad. Sci. USA 97: 10436-10441.  [PDF]

  • Zhong, W., Jiang, M.-M., Schonemann, M.D., Meneses, J.J., Pedersen, R.A., Jan, L.Y., and Jan, Y.N. (2000).  Mouse numb is an essential gene involved in cortical neurogenesis.  Proc. Natl. Acad. Sci. 97:6844-6849.  [PDF]

  • Jan, Y.N. (2000).  Curious Seymour (Book Review).  Cell 101:123-125. [PDF]

  • Jan, Y.N., and Jan, L.Y. (2000).  Humble starts and conserved themes in neurogenetic studies.  Harvey Lecture 94: 21-45. PMID: 11070951.  [PubMed]

  • Jan, L.Y., and Stevens, C.F. (2000). Signalling mechanisms. A decade of signaling. Curr. Opin. Neurobiol. 10:625-630.  [PubMed]

  • Schwappach, B., Zerangue, N., Jan, Y.N. and Jan, L.Y. (2000).  Molecular basis for KATP assembly: Transmembrane interactions mediate association of a K+ channel with an ABC transporter.  Neuron 26: 155-167.  [PubMed]

  • Lin, Y.F., Jan, Y.N. and Jan, L.Y. (2000).  Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.  EMBO J. 19:942-955.  [PubMed]

  • Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2000).  A trafficking checkpoint controls GABAB receptor heterodimerization.  Neuron 27:97-106.  [PubMed]

  • Cooper, E.C., Aldape, K.D., Abosch, A., Barbaro, N.M. Berger, M.S. Peacock, W.S. Jan, Y.N. and Jan, L.Y. (2000).  Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.  Proc. Natl. Acad. Sci. USA 97: 4914-4919.   [PubMed]

  • Zerangue, N., Jan, Y.N., and Jan, L.Y. (2000). An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1. Proc. Natl. Acad. Sci. USA 97:3591-3595. [PubMed]

  • Minor, Jr., D.L., Lin, Y.-F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y., and Berger, J.M. (2000). The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102:657-670. [PubMed]

  • Jan, L.Y., and Jan, Y.N. (2000). Heartfelt Crosstalk: desensitization of the GIRK current. Nat. Cell Biol. 2:E165-E167. [PubMed]

  • Yi, B.A., and Jan, L.Y. (2000). Taking apart the gating of voltage-gated K+ channels. Neuron 27:423-425. [PubMed]

 

 

1999

  • Gao, G.-B., Brenman, J.E., Jan, L.Y., and Jan, Y.N. (1999). Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev. 13:2549-2561.  [PDF]

  • Chan, Y.M., and Jan, Y.N. (1999).  Conservation of neurogenic genes and mechanisms.  Curr. Opin. Neurobiol.5:582-588.  [PubMed]

  • Chan, Y.M., and Jan, Y.N. (1999).  Presenilins, processing of Β-amyloid precursor protein, and notch signaling.  Neuron 23:201-204.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1999).  Asymmetry across species.  Nature Cell Biol. 1:E42-E44.  [PubMed]

  • Lu, B., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1999).  Modes of protein movement that lead to the asymmetric localization of Partner of numb during Drosophila neuroblast division.  Molecul. Cell 4:883-891.  [PubMed]

  • Lu, B., Usui, T., Uemura, T., Jan, L., and Jan, Y.N. (1999).  Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.  Curr. Biol. 9:1247-1250.  [PubMed]

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1999).  Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.  Curr. Biol. 9:155-158.  [PubMed]

  • Margeta-Mitrovic, M., Mitrovic, I., Riley, R.C., Jan, L.Y., and Basbaum, A.I. (1999). Immunohistochemical localization of GABAB receptors in the rat central nervous system. J. Comp. Neurol. 405:299-321.  [PubMed]

  • Cooper, E.C., and Jan, L.Y. (1999). Ion channel genes and human neurological disease: recent progress, prospects, and challenges.  Proc. Natl. Acad. Sci. USA 96:4759-4766.  [PDF][PubMed]

  • Zerangue, N., Schwappach, B., Jan, Y.N., and Jan, L.Y. (1999).  A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane KATP channels.  Neuron 22:537-548.  PMID 10197533 [PubMed]

  • Minor, D.L. Jr., Masseling, S.J., Jan, Y.N., and Jan, L.Y. (1999).  Transmembrane structure of an inwardly rectifying potassium channel.  Cell 96:879-891.  [PubMed]

  • Whistler, J.L., Chuang, H.-H., Chu, P., Jan, L.Y., and von Zastrow, M. (1999).  Functional dissociation of m opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.  Neuron 23:737-746.  [PubMed]

  • Jan, L.Y. (1999). Voltage-dependent K channels. In Potassium Ion Channels: Their Molecular Structure, Function and Diseases, ed. Y. Kurachi, M. Lazdunski and L.Y. Jan. Academic Press, San Diego.

  • Reuveny, E., and Jan, L.Y. (1999). G protein control of G-protein-gated potassium channels. In Potassium Ion Channels: Their Molecular Structure, Function and Diseases, ed. Y. Kurachi, M. Lazdunski and L.Y. Jan.  Academic Press, San Diego.

  • Tinker, A., and Jan, L.Y. (1999). The assembly of inwardly rectifying potassium channels. In Potassium Ion Channels: Their Molecular Structure, Function and Diseases, ed. Y. Kurachi, M. Lazdunski and L.Y. Jan. Academic Press, San Diego.

 

 

1998

  • Chan, Y.M., and Jan, Y.N. (1998).  Roles for proteolysis and trafficking in Notch maturation and signal transduction.  Cell 94:423-426.  [PubMed]

  • Sun, Y., Jan, L.Y., and Jan, Y.N. (1998).  Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.  Development 125:3731-3740.  [PDF]

  • Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.-M., Jan, L.Y., and Jan, Y.N. (1998).  The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.  Proc. Natl. Acad. Sci. USA 95:10637-10642.  [PDF]

  • Lu, B., Rothenberg, M., Jan, L.Y., and Jan, Y.N. (1998).  Partner of Numb, a novel protein that colocalizes with Numb during mitosis, directs Numb asymmetric localization in Drosophila neural and muscle progenitors.  Cell 95:225-235. PMID: 9790529.  [PubMed]

  • Shen, C.-P., Knoblich, J.A., Chan, Y.-M., Jiang, M.-M., Jan, L.Y., and Jan, Y.N. (1998).  Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.  Genes Dev. 12:1837-1846.  [PDF]

  • Zeng C., Younger-Shepherd S., Jan L.Y., and Jan Y.N. (1998).  Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.  Genes Dev. 12:1086-1091.  [PDF]

  • Chien, C.-T., Wang, S., Rothenberg, M., Jan, L.Y., and Jan, Y.N. (1998).  Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.  Mol. Cell. Biol. 18: 598-607.  [PDF]

  • Lu, B., Jan, L.Y., and Jan, Y.N. (1998).  Asymmetric cell division: lessons from flies and worms.  Curr. Opin Genet. Dev. 8:392-399.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1998).  Asymmetric Cell Division.  Nature, 392:775-778.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1998).  Serendipity, the principle of limited sloppiness, and neural development.  Int. J. Dev. Biol. 42:531-533.  [PubMed]

  • Zerangue, N., and Jan, L.Y. (1998). G-protein signaling: fine-tuning signaling kinetics.   Curr. Biol. 8:R313-R316.  [PubMed]

  • Cooper, E.C., Milroy, A., Jan, Y.N., Jan, L.Y., and Lowenstein, D.H. (1998).  Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.  J. Neurosci. 18:955-974.  [PDF]

  • Chuang, H.-h., Yu, M., Jan, Y.N., and Jan, L.Y. (1998).  Evidence that the nucleotide exchange and hydrolysis cycle of G-proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.  Proc. Natl. Acad. Sci. USA 95:11727-11732.  [PDF]

  • Ford, C.E., Skiba, N.P., Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rosal, R., Weng, G., Yang, C.-S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J., and Hamm, H.E. (1998).  Molecular basis for interactions of G protein βγ subunits with effectors.  Science 280:1271-1274.  [PubMed]

  • Stoffel, M., and Jan, L.Y. (1998).  Epilepsy genes: excitement traced to K+ channels.  Nature Genetics 18:6-8.  [PubMed]

 

 

1997

  • Luo, L., Jan, L.Y., and Jan, Y.N. (1997). Rho family small GTP-binding proteins in growth cone signalling. Curr. Opin. Neurobiol. 7:81-86.  [PubMed]

  • Luo, L., Lee, T., Tsai, L., Tang, G., Jan, L.Y., and Jan, Y.N. (1997). Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. Proc. Natl. Acad. Sci. USA 94:12963-12968.  [PDF]

  • Doherty, D., Jan, L.Y., and Jan, Y.N. (1997).  The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.  Development, 124:3881-3893.  [PDF]

  • Lage, P.Z., Jan, Y.N., and Jarman, A.P. (1997).  Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters.  Curr. Biol. 7:166-175.  [PubMed]

  • Anderson, D.J., and Jan, Y.N. (1997).  The Determination of the Neuronal Phenotype.  In Molecular and Cellular Approaches to Neural Development, ed. W.M. Cowan, T.M. Jessell and S.L. Zipursky, pp. 26-63. Oxford University Press, Oxford, United Kingdom.

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1997).  Asymmetric Segregation of the Drosophila Numb Protein during Mitosis: Facts and Speculations.  Cold Spring Harbor Symposia on Quantitative Biology, LXII:71-77.  [PubMed]

  • Wang, S., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1997).  Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.  Development 124:4435-4446.  [PDF]

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1997).  The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.  Proc. Natl. Acad. Sci. USA 94:13005-13010.  [PDF]

  • Shen, C.P., Jan, L.Y., and Jan, Y.N. (1997).  Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila.  Cell 90:449-458. PMID: 9267025.  [PubMed]

  • Clark, I.E., Jan, L.Y., and Jan, Y.N. (1997).  Reciprocal localization of nod and kinesin fusion proteins indicates microtubule polarity in Drosophila oocyte, epithelium, neuron and muscle.  Development 124:461-470.  [PDF]

  • Kanekar, S., Perron, M., Dorsky, R., Harris, W.A., Jan, L.Y., Jan, Y.N., and Vetter, M.L. (1997).  Xath5 participates in a network of bHLH genes in the developing Xenopus retina.  Neuron 19:981-994.  [PubMed]

  • Zhong, W., Jiang, M.M., Weinmaster, G., Jan, L.Y., and Jan, Y.N. (1997).  Differential expression of mammalian Numb, Numblike and Notch1 suggest distinct roles during mouse cortical neurogenesis.  Development 124:1887-1897.  [PDF]

  • Jan, Y.N. (1997).  Pre-empting the arrival of a dark lord (correspondence).  Nature 389:665.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1997).  Receptor-regulated ion channels.  Curr. Opin. Cell Biol. 9:155-160  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1997).  Ways and means for left shifts in the MaxiK channel.  Proc. Natl. Acad. Sci. USA 94:13383-13385.  [PDF]

  • Lüscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C., and Nicoll, R.A. (1997).  G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter action in hippocampal neurons.  Neuron 19:687-695.  [PubMed]

  • Slesinger, P.A., Stoffel, M., Jan, Y.,,N. and Jan, L.Y. (1997).  Defective γ-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.  Proc. Natl. Acad. Sci. USA 94:12210-12217.  [PDF]

  • Chuang, H.H., Jan, Y.N., and Jan, L.Y. (1997).  Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium.  Cell 89:1121-1132.  PMID: 9215634 [PubMed]

  • Collins, A. Chuang, H.H., Jan, Y.N., and Jan, L.Y. (1997). Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.  Proc. Natl. Acad. Sci. USA 94:5456-5460.  [PDF]

  • Huang, C.L., Jan, Y.,N., and Jan, L.Y. (1997).  Binding of the G protein βγ subunit to multiple regions of G protein-gated inward rectifying K+ channels.  FEBS Lett. 405:291-298.  [PubMed]

  • Yang, J., Yu, M., Jan, Y.N., and Jan, L.Y. (1997).  Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.  Proc. Natl. Acad. Sci. USA 94:1568-1572.  [PDF]

  • Signorini, S., Liao, Y.J., Duncan, S.A., Jan, L.Y., and Stoffel, M. (1997).  Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.  Proc. Natl. Acad. Sci. USA 94:923-927.  [PDF]

  • Vivaudou, M., Chan, K.W., Sui, J.L., Jan, L.Y., Reuveny, E., and D.E. Logothetis (1997).  Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.  J. Biol. Chem. 272:31553-31560.  [PDF]

  • Jan, L.Y., and Jan, Y.N. (1997).  Voltage-gated and inwardly rectifying potassium channels. J. Physiol. 505:267-282. PMCID: PMC1160062.  [PDF]

  • Jan, L.Y., and Jan, Y.N. (1997).  Cloned potassium channels from eukaryotes and prokaryotes.  Annu. Rev. Neurosci. 20:91-123.  [PubMed]

  • Jan,L.Y. (1997). Ion Channels-Molecules in Action (book review). Cell 89:829-830.   [PDF]

  • Lumsden, A. and Jan, Y.N. (1997).  Editorial overview:  The end of the beginning Curr. Opin. Neurobiol. 7:3-6. [PDF]

 

 

1996

  • Kolodziej, P.A. Timpe, L.C., Mitchell, K.J., Fried, S.R., Goodman, C.S., Jan, L.Y., and Jan, Y.N. (1996). frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87:197-204.  [PubMed]

  • Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1996). Differential effects of the Rac GTPase on purkinje cell axons, dendrites and dendritic spines. Nature 379:837-840. PMID: 8587609.  [PubMed]

  • Lane, M.E., Sauer, K., Wallace, K., Jan, Y.N., Lehner, C.F., and Vaessin, H. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87:1225-1235.  [PubMed]

  • Chien, C.T., Hsiao, C.D., Jan, L.Y., and Jan, Y.N. (1996).  Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.  Proc. Natl. Acad. Sci. USA 93:13239-13244.  [PDF]

  • Doherty, D., Feger, G., Younger-Shephard, S., Jan, L.Y., and Jan, Y.N. (1996).  Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, In Drosophila wing formation.  Genes Dev. 10:421-434.  [PubMed]

  • Frise, E., Knoblich, J.A., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1996).  The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.  Proc. Natl. Acad. Sci. USA 93:11925-11932.  [PDF]

  • Kraut, R., Chia, W., Jan, L.Y., Jan, Y.N., and Knoblich, J.A. (1996).  Role of inscuteable in orienting asymmetric cell divisions in Drosophila.  Nature 383:50-55. PMID: 8779714.  [PubMed]

  • Guo, M., Jan, L.Y., and Jan, Y.N. (1996).  Control of daughter cell fates during asymmetric division; interaction of Numb and Notch.  Neuron 17:27-41. PMID: 8755476.  [PubMed]

  • Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. and Jan, Y.N. (1996).  Asymmetric localization of a mammalian Numb homologue during mouse cortical neurogenesis.  Neuron 17:43-53.  [PubMed]

  • Fakler, B., Schultz, J.H., Yang, J., Schulte, U., Brändle, U., Zenner, H.P., Jan, L.Y., and Ruppersberg, J.P. (1996).  Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.  EMBO J. 15:4093-4099.  [PubMed]

  • Liao, Y.J., Jan, Y.N., and Jan, L.Y. (1996).  Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brains.  J. Neurosci. 16:7137-7150.  [PDF]

  • Tinker, A., Jan, Y.N., and Jan, L.Y. (1996).  Regions responsible for the assembly of inwardly rectifying potassium channels.  Cell 87:857-868.   PMID: 8945513 [PubMed]

  • Slesinger, P.A., Patil, N. Liao Y.J., Jan, Y.N., Jan, L.Y., and Cox, D.R. (1996).  Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.  Neuron 16: 321-331.  [PubMed]

  • Reuveny, E. Jan, Y.N., and Jan, L.Y. (1996).  Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K+-selective permeation.  Biophys. J. 70: 754-761  [PubMed]

  • Collins, A., German, M.S., Jan, Y.N., Jan, L.Y., and Zhao, B. (1996).  A strongly inwardly rectifying K+ channel that is sensitive to ATP.  J.Neurosci. 16:1-9.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1996). Membrane permeability–Editorial overview. Curr. Opin. Cell Biol. 8:449-451. [PDF]

  • Luo, L., Jan, L.Y., and Jan, Y.N. (1996). Small GTPases in axon outgrowth. Perspect. Dev. Neurobiol. 4:199-204.

 

 

1995

  • Eaton, S., Auvien, P., Luo, L., Jan, Y.N., and Simons, K. (1995). CDC42 and Rac1 control different actin dependent processes in the Drosophila wing disc epithelium. J. Cell. Biol. 131:151-164.  [PDF]

  • Kolodziej, P., Jan, L.Y., and Jan, Y.N. (1995). Mutations that affect the length, fasciculation and ventral orientation of specific axons in the Drosophila embryo. Neuron 15:273-286.  [PubMed]

  • Feger, G., Vaessin, H., Su, T.T., Wolff, E., Jan, L.Y., and Jan, Y.N. (1995). dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila. EMBO J. 14:5387-5398.  [PubMed]

  • Jarman, A.P., Sun, Y., Jan, L.Y., and Jan, Y.N. (1995).  Role of the proneural gene, atonal in formation of Drosophila chordotonal organs and photoreceptors.  Development 121:2019-2030.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (1995).  Maggot's hair and bug's eye: role of cell interactions and intrinsic factors in cell fate specification.  Neuron 14:1-5.  [PubMed]

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1995).  Asymmetric segregation of Numb and Prospero during cell division.  Nature 377:624-627. PMID: 7566172.  [PubMed]

  • Guo, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1995).  tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.  Neuron 14:913-925.  [PubMed]

  • Xu, J., Yu, W., Jan, Y.N., Jan, L.Y., and Li, M. (1995).  Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.  J. Biol. Chem. 270:24761-24768.  [PDF]

  • Klumpp, D.J., Song, E.J., Ito, S., Sheng, M.H., Jan, L.Y., and Pinto, L.H. (1995).   The Shaker-like potassium channels of the mouse rod bipolar call and their contributions to the membrane current.  J. Neurosci. 15:5004-5013.  [PDF]

  • Yang, J., Jan, Y.N., and Jan, L.Y. (1995).  Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.  Neuron 15:1441-1447.  PMID: 8845166 [PubMed]

  • Slesinger, P.A., Reuveny, E., Jan, Y.N., and Jan, L.Y. (1995).  Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.  Neuron 15:1145-1156.  [PubMed]

  • Huang, C-L., Slesinger, P.A., Casey, P.J., Jan, Y.N., and Jan, L.Y. (1995).  Evidence that direct binding of Gßγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.  Neuron 15:1133-1143.  [PubMed]

  • Yang, J., Jan, Y.N., and Jan, L.Y. (1995).  Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.  Neuron 14:1047-1054.  [PubMed]

  • Sheng, M., Jan, Y.N., and Jan, L.Y. (1995). The molecular organization of voltage-dependent K+ channel in vivo. Progress in Brain Research 105:87-93.

  • Kim, E., Niethammer, M., Rothschild, A., Jan, Y.N. and Sheng, M. (1995).  Clustering of Shaker type K+channels by direct interaction with the PSD-95/SAP90 family of membrane-associated guanylate kinases.  Nature 378:85-88.[PDF]

 

 

1994

  • Luo, L., Liao, Y.J., Jan, L.Y., and Jan, Y.N. (1994). Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8:1787-1802.  [PubMed]

  • Vaessin, H., Brand, M., Jan, L.Y., and Jan, Y.N. (1994).  daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.  Development 120:935-945.  [PDF]

  • Jarman, A.P., Grell, E.H., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1994).  atonal is the proneural gene for Drosophila photoreceptors.  Nature 369:398-400. PMID: 8196767.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1994).  Genetic control of cell fate specification in Drosophila peripheral nervous system.  Annu. Rev. of Genet. 28:373-393.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1994).  Neuronal cell fate specification in Drosophila.  Curr. Opin. Neurobiol. 4:8-13.  [PubMed]

  • Rhyu, M.S., Jan, L.Y., and Jan, Y.N. (1994).  Asymmetric distribution of numb protein during division of the Sensory Organ Precursor cell confers distinct fates to daughter cells.  Cell 76:477-491. PMID: 8313469.  [PubMed]

  • Jongens, T.A., Ackerman, L.D., Swedlow, J.R., Jan, L.Y., and Jan, Y.N. (1994).  Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.  Genes Dev. 8:2123-2136.  [PubMed]

  • Clark, I., Giniger, E., Ruohola-Baker, H., Jan, L.Y., and Jan, Y.N. (1994).  Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.  Curr. Biol. 4:289-300.  [PubMed]

  • Ruohola-Baker, H., Jan, L.Y., and Jan, Y.N. (1994).  The role of gene cassettes in axis formation during Drosophila oogenesis.  Trends Genet. 10:89-94.  [PubMed]

  • Feder, J.N., Li, L., Jan, L.Y., and Jan, Y.N. (1994).  Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene hairy.  Genomics 20:56-61.  [PubMed]

  • Liu, H., Wang, H., Sheng, M., Jan, Y.N., Jan, L.Y., and Basbaum, A.I. (1994).  Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.  Proc. Natl. Acad. Sci. USA 91:8383-8387.  [PDF]

  • Sheng, M., Cummings, J., Roldan, L.A., Jan, Y.N., and Jan, L.Y. (1994).  Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.  Nature 368: 144-147.  [PubMed]

  • Sheng, M., Tsaur, M-L, Jan, Y.N., and Jan, L.Y. (1994). Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.  J. Neurosci. 14:2408-2417.  [PDF]

  • Lopez, G., Jan, Y.N., and Jan, L.Y. (1994).  Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.  Nature 367: 179-182.  [PubMed]

  • Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iñiguez-Lluhi, J.A., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N., and Jan, L.Y. (1994).  Activation of the cloned muscarinic potassium channel by G protein βγ subunits.  Nature 370:143-146.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1994).  Potassium channels and their evolving gates.  Nature 371:119-122.  [PubMed]

  • Li, M., Unwin, N., Stauffer, K.A., Jan, Y.N., and Jan, L.Y. (1994). Images of purified Shaker potassium channels. Curr. Biol. 4:110-115. [PDF]

  • Giniger, E., Tietje, K., Jan, L.Y., and Jan, Y.N. (1994). Iola encodes a putative transcription factor required for axon growth and guidance in Drosophila. Development 120:1385-1398. [PDF]

  • Jan, L.Y., and Jan, Y.N. (1994). Editorial overview–Membrane permeability. Curr. Opin. Cell Biol. 6:569-570. [PDF]

 

 

1993

  • Giniger, E., Wells, W.A.E., Jan, L.Y., and Jan, Y.N. (1993). Tracing neurons with a Kinesin-ß-Galactosidase fusion protein. Roux's Arch. Dev. Biol. 202:112-122.  [PDF]

  • Giniger, E., Jan, L.Y., and Jan, Y.N. (1993). Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development 117:431-440.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (1993). Peripheral Nervous System. In The Development of Drosophila melanogaster, ed. M. Bate and A. Martinez-Arias, Chapter 20, pp. 1207-1244. Cold Spring Harbor Press, Cold Spring Harbor, New York.  

  • Jan, Y.N., and Jan, L.Y. (1993).  HLH protein, fly neurogenesis and vertebrate myogenesis.  Cell 75:827-830.  [PubMed]

  • Ghysen, A., Dambly-Chaudière, C., Jan, L.Y., and Jan, Y.N. (1993).  Cell interaction and gene interaction in peripheral neurogenesis.  Genes Dev. 7:723-733.  [PubMed]

  • Jarman, A.P., Grau, Y., Jan, L.Y., and Jan, Y.N. (1993).  atonal is a proneural gene for chordotonal organs in the Drosophila peripheral nervous system.  Cell 73:1307-1321. PMID: 8324823.  [PubMed]

  • Jarman, A.P., Brand, M., Jan, L.Y., and Jan, Y.N. (1993).  The regulation and function of helix-loop-helix gene, asense, in Drosophila neural precursors.  Development 119:19-29.  [PDF]

  • Brand, M., Jarman, A.P., Jan, L.Y., and Jan, Y.N. (1993).  asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.  Development 119:1-17.  [PDF]

  • Bodmer, R., Jan, L.Y., and Jan, Y.N. (1993).  A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.  Roux's Arch. Dev. Biol. 202:371-381.

  • Blochlinger, K., Jan, L.Y., and Jan, Y.N. (1993).  Post-embryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila.  Development 117:441-450.  [PDF]

  • Siegel, V., Jongens, T.A., Jan, L.Y., and Jan, Y.N. (1993).  pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.  Development 119:1187-1202.  [PDF]

  • Theurkauf, W.E., Alberts, B.M., Jan, Y.N., and Jongens, T.A. (1993).  A central role for microtubules in the differentiation of Drosophila oocytes.  Development 118:1169-1180.  [PDF]

  • Ruohola-Baker, H., Grell, E., Chou, T.B., Baker, D., Jan, L.Y., and Jan, Y.N. (1993).  Spatially localized Rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis.  Cell 73:953-965.  [PubMed]

  • Feder, J.N., Jan, L.Y., and Jan, Y.N. (1993).  A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.  Mol. Cell Biol. 13:105-113.  [PDF]

  • Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993).  The S4-S5 loop contributes to the ion selective pore of potassium channels.  Neuron 11:739-749.  [PubMed]

  • Sheng, M., Liao, J., Jan, Y.N., and Jan, L.Y. (1993). Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.  Nature 365:72-75.  PMID: 8361540 [PubMed]

  • Kubo, Y., Reuveny, E., Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993).  Primary structure and functional expression of a rat G protein coupled muscarinic potassium channel.  Nature 364:802-806.  PMID: 8355805[PubMed]

  • Kubo, Y., Baldwin, T.J., Jan, Y.N., and Jan, L.Y. (1993).  Primary structure and functional expression of a mouse inward rectifier potassium channel.  Nature 362:127-133.  PMID: 7680768.[PubMed]

  • Crowley, T.E., Hoey, T., Liu, J.K., Jan, Y.N., Jan, L.Y., and Tjian, R. (1993). A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature 361:557-561. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1993). Functional gene cassettes in development. Proc. Natl. Acad. Sci. USA. 90:8305-8307. PMCID: PMC47343. [PDF]

  • Li, M., Isacoff, E., Jan, Y.N., and Jan, L.Y. (1993). Assembly of potassium channels. In Molecular basis of ion channels and receptors involved in nerve excitation, synaptic transmission and muscle contraction. Ann. N.Y. Acad. Sci. 707:51-59. [PDF]

  • Boulianne, G.L., de la Concha, A., Campos-Ortega, J.A., Jan, L.Y., and Jan, Y.N. (1993) The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO 12: 2586. [PDF]

 

 

1992

  • Bellen, H., Vaessin, H., Bier, E., Kolodkin, A., D'Evelyn, D., Kooyer, S., and Jan, Y.N. (1992). The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics 131:365-375.  [PDF]

  • Hartenstein, V., and Jan, Y.N. (1992). Studying Drosophila Embryogenesis with P-lacZ Enhancer Trap Lines. Roux's Arch. Dev. Biol. 201:194-220.

  • Bier, E., Vaessin, H., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1992).  deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.  Genes Dev. 6:2137-2151.  [PubMed]

  • Rao, Y., Bodmer, R., Jan, L.Y., and Jan Y.N. (1992).  The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.  Development 116:31-40.  [PDF]

  • Younger-Shepherd, S., Vaessin, H., Bier, E., Jan, L.Y., and Jan, Y.N. (1992).  deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination.  Cell 70:911-922.  [PubMed]

  • Rutledge, B. J., Zhang, K., Bier, E., Jan, Y.N., and Perrimon, N. (1992).  The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.  Genes Dev. 6:1503-1517.  [PubMed]

  • Jan, Y. N., and Jan, L.Y. (1992).  Neuronal specification.  Curr. Opin. Genet. Dev. 2:608-613.  [PubMed]

  • Jongens, T.A., Hay, B., Jan, L.Y., and Jan, Y.N. (1992).  The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila.  Cell 70:569-584.  [PubMed]

  • Li, M., Jan, Y.N., and Jan, L.Y. (1992). Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker K+ channel.  Science 257:1225-1230.  PMID: 1519059 [PubMed]

  • Sheng, M., Tsaur, M-L, Jan, Y.N., and Jan, L.Y. (1992).  Subcellular segregation of two A-type K+ channel proteins in rat central neurons.  Neuron 9:271-284.  [PubMed]

  • Tsaur, M.L.,Sheng, M., Lowenstein, D.H., Jan, Y.N., and Jan, L.Y. (1992).  Differential expression of K+ channel mRNAs in the rat brain and down regulation in the hippocampus following seizures.  Neuron 8:1055-1067.  [PubMed]

  • Jan, L.Y., and Y.N. Jan. (1992).  Structural elements involved in specific K+ channel functions.  Annu. Rev. Physiol. 54:537-555.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1992).  Tracing the roots of ion channels.  Cell 69:715-718.  [PubMed]

  • Baldwin, T.J., Isacoff, E., Li, M., Lopez, G.A., Sheng, M., Tsaur, M.L., Jan, Y.N. and Jan, L.Y. (1992). Elucidation of biophysical and biological properties of voltage-gated potassium channels. Cold Spring Harbor Symposium  vol: LVII, pp.491-499.

 

 

1991

  • Boulianne, G.L, de la Concha, A., Campos-Ortega, J.A., Jan, L.Y., and Jan, Y.N. (1991).  The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.  EMBO J. 10:2975-2983.  [PubMed]

  • Rao, Y., Jan, L.Y., and Jan, Y.N. (1991).  Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.  Genes Dev. 5:1577-1588.  [PubMed]

  • Blochlinger, K., Jan, L.Y., and Jan, Y.N. (1991).  Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.  Genes Dev. 5:1124-1135.  [PubMed]

  • Campos-Ortega, J., and Jan, Y.N. (1991).  Genetic and molecular bases of neurogenesis in Drosophila melanogaster.  Annu. Rev. Neurosci. 14:399-420  [PubMed]

  • Vaessin, H., Grell, E., Wolff, E., Bier, E., Jan, L.Y., and Jan, Y.N. (1991).  prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila.  Cell 67: 941-953. PMID: 1720353.  [PubMed]

  • Ruohola, H., Bremer, K.A., Baker, D., Swedlowe, J.R., Jan, L.Y., and Jan, Y.N. (1991).  Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila.  Cell 66:433-449.  [PubMed]

  • Isacoff, E.Y., Jan, Y.N., and Jan, L.Y. (1991).  Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel.  Nature 353:86-90.  [PubMed]

  • Lopez, G.A., Jan, Y.N., and Jan, L.Y. (1991).  Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.  Neuron 7:327-336.  [PubMed]

  • Baldwin, T.B., Tsaur, M-L, Lopez, G.A., Jan, Y.N., and Jan, L.Y. (1991).  Characterization of a mammalian K+ channel cDNA for an inactivating voltage-sensitive K+ channel.  Neuron 7:471-483.  [PubMed]

  • Papazian, D.M., Timpe, L.C., Jan, Y.N., and Jan, L.Y. (1991).  Alteration of voltage-dependence of Shaker K+ channel by mutations in the S4 sequence.  Nature 349:305-310.  [PubMed]

  • Timpe, L.C., Isacoff, E., Kimmerly, W., Papazian, D., Jan, Y.N., and Jan, L.Y. (1991).  Molecular studies of voltage-sensitive potassium channels. Fidia Research Foundation Symposium Series, vol. 7, pp.193-202.

 

 

1990

  • Jan, Y.N., and Jan, L.Y. (1990).  Genes required for specifying cell fates in Drosophila embryonic sensory nervous system.  Trends Neurosci. 13:493-498.  [PubMed]

  • Vaessin, H., Caudy, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1990).  The role of helix-loop-helix proteins in Drosophila neurogenesis.  Cold Spring Harbor Symposia on Quantitative Biology LV: 239-245.  [PubMed]

  • Bodmer, R., Jan, L.Y., and Jan, Y.N. (1990).  A new homeobox-containing gene, msh-2, is transiently expressed early during mesodcerm formation of Drosophila.  Development 110:661-670.  [PubMed]

  • Blochlinger, K., Bodmer, R., Jan, L.Y., and Jan, Y.N. (1990).  Patterns of expression of Cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.  Genes Dev. 4:1322-1331.  [PubMed]

  • Rao,Y., Jan, L.Y., and Jan, Y.N. (1990).  Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.  Nature 345:163-167.  [PubMed]

  • Bier, E., Jan, L.Y., and Jan, Y.N. (1990).  rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.  Genes Dev. 4:190-203.  [PubMed]

  • Hay, B., Jan, L.Y., and Jan, Y.N. (1990). Localization of vasa, a component of Drosophila polar granules, in maternal effect mutants that alter embryonic anteroposterior polarity.  Development 109:425-433.  [PubMed]

  • Klaiber, K., Williams, N., Roberts, T.M., Papazian, D.M., Jan, L.Y., and Miller, C. (1990).  Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.  Neuron 5:211-216.  [PubMed]

  • Isacoff, E., Jan, Y.N., and Jan, L.Y. (1990).  Evidence for the formation of heteromulteric potassium channels in Xenopus oocytes.  Nature 345: 530-534.  PMID: 2112229 [PubMed]

  • Schwarz, T.L., Papazian, D.M., Carretto, R.C., Jan, Y.N., and Jan, L.Y. (1990).   Immunological characterization of K+-channel components from the Shaker locus and the differential distribution of splicing variants in Drosophila.  Neuron 4:119-127.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1990).  How might the diversity of potassium channels be generated?  Trends Neurosci. 13:413-419.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1990).  A superfamily of ion channels.  Nature 345:672.  [PubMed]

  • Isacoff, E., Papazian, D., Timpe, L., Jan, Y.N., and Jan, L.Y. (1990). Molecular studies of voltage-gated potassium channels. Cold Spring Harbor Symposia on Quantitative Biol., vol. LV, pp. 9-17. [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1990).  In Rememberance of Stephen W. Kuffler, ed. U.J. McMahan, pp. 47-50. Sinauer Inc., Sunderland, MA.

 

 

1989

  • Bier, E., Vaessin, H., Shepherd, S., Lee, K., McCall, K., Barbel, S., Ackerman, L., Carretto, R., Uemura, T., Grell, E., Jan, L.Y., and Jan, Y.N. (1989). Searching for Pattern and Mutation in the Drosophila Genome with a P-lacZ Vector. Genes Dev. 3:1273-1287.[PDF]

  • Bodmer, R., Carretto, R., and Jan, Y.N. (1989).  Neurogenesis of the Peripheral Nervous System in Drosophila Embryos: DNA replication Patterns and Cell lineages.  Neuron 3:21-32.  [PubMed]

  • Uemura, T., Shepherd, S., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1989).  numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryo.  Cell 58:349-360. PMID: 2752427.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1989). Voltage-sensitive ion channels. Cell 56:13-25.  [PubMed]

  • Leung, H.T., Branton, W.D., Phillips, H.S., Jan, L.Y., and Byerly, L. (1989). Spider Toxins selectively block calcium currents in Drosophila. Neuron 3:767-772. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1989). Genes involved in early neural development of Drosophila. In: The Assembly of the Nervous System. 47th Symposium of Soc. of Dev. Biology pp. 1-16. Alan R. Liss, Inc., New York.

  • Schwarz, T., Carretto, R., Papazian, D., Tempe, B., Timpe, L., Jan, Y.N., and Jan, L.Y. (1989). A family of potasium channels from the Shaker locus in Drosophila. In Molecular Biology of Neuroreceptors and Ion Channels (Maelicke, A., Ed.). New York: Springer-Verlag, pp. 215-229.

  • Murre, C., Schonleber McCaw, P., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., Weintraub, H. and Baltimore, D. (1989).  Interactions between heterologous  helix-loop-helix proteins bind specifically to a common DNA sequence.  Cell 58:537-544. [PDF]

     

 

 

1988

  • Katz, F., Moats, W., and Jan, Y.N. (1988). A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). EMBO J. 7:3471-3477  [PubMed]

  • Bier, E., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1988). Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science 240: 913-916.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1989).  Genes involved in early neural development of Drosophila.  In The Assembly of the Nervous System. 47th Symposium of Soc. of Dev. Biology, pp. 1-16. Alan R. Liss, Inc., New York.

  • Murre, C., Schonleber McCaw, P., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., Weintraub, H., and Baltimore, D. (1989).  Heterodimers of helix-loop-helix proteins bind specifically to a common DNA sequence.  Cell 58:537-544.  [PubMed]

  • Caudy, M., Vaessin, H., Brand, M., Tuma, R., Jan, L.Y., and Jan, Y.N. (1988).  daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.  Cell 55:1061-1067. PMID: 3203380.  [PubMed]

  • Dambly-Chaudiere, C., Ghysen, A., Jan, L.Y., and Jan, Y.N. (1988).  The determination of sense organs in Drosophila: interaction of scute with daughterless.  Roux's Arch. Dev. Biol. 197:419-423.[PDF]

  • Caudy, M., Grell, E., Dambly-Chaudiere, C., Ghysen, A., Jan, L.Y., and Jan, Y.N. (1988).  The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.  Genes Dev. 2:843-852.  [PubMed]

  • Blochlinger, K.B., Bodmer, R., Jack, J., Jan, L.Y., and Jan, Y.N. (1988).  Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila.  Nature 333:629-635.  [PubMed]

  • Hay, B., Jan, L.Y., and Jan, Y.N. (1988).  A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.  Cell 55:577-587.  [PubMed]

  • Hay, B., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1988).  Identification of a component of Drosophila polar granules.  Development 103: 625-640.  [PubMed]

  • Timpe, L.C., Jan, Y.N., and Jan, L.Y. (1988).  Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.   Neuron 1:659-667.  [PubMed]

  • Tempel, B.L, Jan, Y.N., and Jan, L.Y. (1988).  Cloning of a probable potassium channel from mouse brain.  Nature 332:837-839.  [PubMed]

  • Timpe, L.C., Schwarz, T.L., Tempel, B.L, Papazian, D.M., Jan, Y.N., and Jan, L.Y. (1988).   Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.  Nature 331:143-145.  [PubMed]

  • Schwarz, T.L., Tempel, B.L, Papazian, D.M., Jan, Y.N., and Jan, L.Y. (1988).  Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.  Nature 331:137-142. PMID: 2448635.  [PubMed]

  • Papazian, D.M., Schwarz, T.L., Tempel, B.L., Timpe, L.C., and Jan, L.Y. (1988). Ion channels in Drosophila. Annu. Rev. Physiol. 50:379-394. [PDF]

  • Jan, L.Y., Papazian, D.M., Schwarz, T.L., Tempel, B.L., Timpe, L.C., and Jan, Y.N. (1988). Molecular Studies of Voltage-Sensitive Potassium Channels.  Proceedings of the First NIMH Conference of Molecular Neurobiology, vol. 1, pp. 27-32.

  • Jan, Y.N., and Jan, L.Y. (1988). Mutations Affecting Neurogenesis and Neuronal Identity in Drosophila Melanogaster. Proceedings of the First NIMH Conference on Molecular Neurobiology, vol. 1 pp.229-233.

 

 

1987

  • Bodmer, R., and Jan, Y.N. (1987). Morphological differentiation of the embryonic peripheral neurons in Drosophila. Roux's Arch. Dev. Biol. 196:69-77.  [PDF]

  • Jan, Y.N., Bodmer, R., Jan, L.Y., Ghysen, A., and Dambly-Chaudière, C. (1987). Mutations affecting the embryonic development of the peripheral nervous system in Drosophila. In Molecular Entomology, ed. Liss, Alan R., 49:45-56. New York.

  • Bodmer, R., Jan Barbel, S., Shepherd, S., Jack, J.W., Jan, L.Y., and Jan, Y.N. (1987).  Transformation of sensory organs by mutations of the cut locus of Drosophila melanogaster.  Cell 51: 293-307.  [PubMed]

  • Timpe, L.C., and Jan, L.Y. (1987).  Gene dosage and complementation analysis of the Shaker locus in Drosophila.  J. Neurosci. 7:1307-1317.  [PDF]

  • Tempel, B.L., Papazian, D.M., Schwarz, T.L., Jan, Y.N., and Jan, L.Y. (1987).  Sequence of a probable K+ channel component in Drosophila deduced from Shaker cDNA.  Science 237:770-775.  [PubMed]

  • Papazian, D.M., Schwarz, T.L., Tempel, B.L., Jan, Y.N., and Jan, L.Y. (1987).  Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.  Science 237:749-753.  PMID: 2441470 [PubMed]

  • Royden, C.S., Pirrotta, V., and Jan, L.Y. (1987). The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12. Cell 51:165-173. [PDF]

  • Bowers, C.W., Phillips, H.S., Lee, P., Jan, Y.N., and Jan, L.Y. (1987). Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta. Proc. Natl. Acad. Sci. USA 84:3506-3510. [PDF]

  • Branton, D., Kolton, L., Jan, Y.N., and Jan, L.Y. (1987). Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J. Neurosci. 7:4195-4200. [PDF]

  • Branton, D., Phillips, H. and Jan, Y.N. (1987).  The LHRH family of peptide messengers in the frog nervous system.  Progress in Brain Research 68:205‑215.

 

 

1980-1986

  • Ghysen, A., Dambly-Chaudiere, C., Aceves, E., Jan, L.Y., and Jan, Y.N. (1986). Sensory neurons and peripheral pathways in Drosophila embryos. Roux's Arch. Dev. Biol. 195:281-289.[PDF]

  • Bowers, C., Jan, L.Y., and Jan, Y.N. (1986).  A substance P-like peptide in bullfrog autonomic nerve terminals-Anatomy, biochemistry and physiology.  Neuroscience 19:343-356.  [PubMed]

  • Dambly-Chaudiere, C., Ghysen, A., Jan, Y.N., and Jan, L.Y. (1986). Muscle connections between imaginal discs in Drosophila. Dev. Biol. 113:288-294.[PDF]

  • Ghysen, A., Jan, L.Y., and Jan, Y.N. (1985). Segmental determination in Drosophila central nervous system. Cell 40:943-948.  [PubMed]

  • Jan, Y.N., Ghysen, A., Christoph, I., Barbel, S., and Jan, L.Y. (1985). Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster. J. Neurosci. 5:2453-2464.  [PubMed]

  • Jan, L.Y., Papazian, D., Timpe, L., O'Farrell, P., and Jan, Y.N. (1985). Application of Drosophila molecular genetics in the study of neural function-studies of the Shaker locus for a potassium channel.  Trends Neurosci. 8:2334-238. [PDF]

  • Jan, L.Y., Barbel, S., Timpe, L., Laffer, C., Salkoff, L., O'Farrell, P., and Jan, Y.N. (1985).  Studies of Shaker mutations affecting a K+ channel in Drosophila. Current Topics in Membrane and Transport 23:67-77.

  • Jan, Y.N., and Jan, L.Y. (1983). LHRH-like peptide–A neurotransmitter capable of “action at a distance” in autonomic ganglia.  Trends Neurosci. 6:320-325. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1983). Some features of peptidergic transmission. Progress in Brain Research, 58:49-59.

  • Jan, Y.N., and Jan, L.Y. (1983). Electrophysiological studies of peptide actions: Techniques used and novel features of peptidergic transmission. In: Brain Peptides, eds. Krieger, D.T., Brownstein, M., Martin, J.B., pp. 547-563, John Wiley and Sons, New York.

  • Jan, Y.N., and Jan, L.Y. (1983). Coexistence and co-release of cholinergic and peptidergic transmitters in preganglionic C fibers of bullfrog sympathetic ganglia. Fed. Proc. 42:2929-2933.

  • Jan, L.Y., Barbel, S., Timpe, L., Laffer, C., Salkoff, L., O'Farrell, P., and Jan, Y.N. (1983). Mutating a gene for a potassium channel by hybrid dysgenesis. An approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology 48:233-245.

  • Jan, Y.N., Bowers, C., Branton, D., Evans, L., and Jan, L.Y. (1983). Roles of peptides in neuronal function–Studies using frog autonomic ganglia.  Cold Spring Harbor Symposia on Quantitative Biology 48:363-374.

  • Ghysen, A., Dambly-Chaudiere, C., Jan, L.Y., and Jan, Y.N. (1982). Segmental differences in the protein content of Drosophila imaginal discs. EMBO J. 1:1373-1379. [PDF]

  • Jan, L.Y., and Jan, Y.N. (1982) Antibodies to horseradish peroxidase as a neuronal marker in Drosophila and in grasshopper embryos. Proc. Natl. Acad. Sci. USA 79:2700-2704.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1982).  Peptidergic transmission in sympathetic ganglia of the frog.   J. Physiol. 327:219-246.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1982). Genetic and immunologic studies of the synapse in Drosophila.  In Ciba Foundation Symposium: Neuropharmacology of Insects, pp. 221-239.

  • Jan, Y.N., and Jan, L.Y. (1982). LHRH-like peptide as a transmitter in sympathetic ganglia. In: Frontiers in Neuroendocrinology, Vol. 7, eds., Ganong, W.F. and Martini, L., pp. 211-230, Raven Press.

  • Jan, L.Y., and Jan, Y.N. (1981). Mutations of the synapse in Drosophila. In Development in the Nervous System eds. D.R. Garrod and J.D. Feldman, Cambridge. pp. 347-359. Cambridge University Press.

  • Jan, L.Y., and Jan Y.N. (1981). Role of an LHRH-like peptide as a neurotransmitter in sympathetic ganglia of the frog. Fed. Proc. 40:2560-2564. PMID: 6115771.  [PubMedCentral]

  • Jan, L.Y., Jan, Y.N., and Brownfield, M.S. (1980).  Peptidergic transmitters in synaptic boutons of sympathetic ganglia.  Nature 288:380-382. PMID: 6107864.[PubMed]

  • Jan, Y.N., Jan, L.Y., and Kuffler, S.W. (1980).  Further evidence for peptidergic transmission in sympathetic ganglia.  Proc. Natl. Acad. Sci. USA 77:5008-5012.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (1980). Genetic Dissection of Synaptic transmission in Drosophila Melanogaster.  In Insect Neurobiology and Pesticide Action, ed. F.E. Rickett, pp. 161-168, London:  The Society of Chemical Industry.

 

 

1974-1979

  • Jan, Y.N., Jan, L.Y., and Kuffler, S.W. (1979).  A peptide as a possible transmitter in sympathetic ganglia of the frog.  Proc. Natl. Acad. Sci. USA 76:1501-1505.  [PDF]

  • Heuser, J.E., Reese, T.S., Dennis, M.J., Jan, Y.N., Jan, L.Y., and Evans, L. (1979).   Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.  J. Cell Biol. 81:275-300. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1978).  Genetic dissection of short-term and long-term facilitation in Drosophila.  Proc. Natl. Acad. Sci. USA 75:515-519.  [PDF]

  • Wu, C.F., Ganetzky, B., Jan, L.Y., Jan, Y.N., and Benzer, S. (1978). A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc. Natl. Acad. Sci. USA 75:4047-4051. [PDF]

  • Jan, Y.N., Jan, L.Y., and Dennis, M.J. (1977).  Two mutations of synaptic transmission in Drosophila.  Proc. Roy. Soc. Lond. B 198:87-108. PMID: 20636.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1976).  L-glutamate as an excitatory transmitter at Drosophila larval neuromuscular junction.  J. Physiol. 262:215-236.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1976).  Properties of the larval neuromuscular junction in Drosophila melanogaster.  J. Physiol. 262:189-214.  [PubMed]

  • Dudai, Y., Jan, Y.N., Byers, D., Quinn, W.G. and Benzer, S. (1976).  dunce a mutant of Drosophila deficient in learning.  Proc. Natl. Acad. Sci. USA 73:1684‑1688. [PDF]

  • Jan, L.Y., and Revel, J.P. (1975). Hemocyanin-antibody labeling of rhodopsin in mouse retina for a scanning electron microscope study. J. Supramol. Structure 3:61-66.

  • Jan, L.Y. (1975). The isomeric configuration of the bacteriorhodopsin chromophore. Vision Res. 15:1081-1086.

  • Cohen, R.J., Jan, Y.N., Matricon, J. and Delbrück, M. (1975).  Avoidance response, house response, and wind responses of the sporangiophore of Phycomyces.  J. Gen. Physiol. 66:67‑95. [PDF]

  • Jan, L.Y., and Revel, J.P. (1974). Ultrastructural localization of rhodopsin in the vertebrate retina. J. Cell Biol. 62:257-273. [PDF]

  • Jan, Y.N. (1974).  Properties and cellular location of chitin synthetase in Phycomyces blakesleeanus.  J. Biol. Chem. 249:1973‑1979. [PDF]

 

 
   
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