Van Voorhis, V.A., and Morgan, D.O. (2014) Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr. Biol. 24, 1556-1562. open pdf

Lu, D., Hsiao, J.Y., Davey, N.E., Van Voorhis, V.A., Foster, S.A., Tang, C., and Morgan, D.O. (2014) Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J. Cell Biol. 207, 23-39. open pdf

Lyons, N.A., Fonslow, B.R., Diedrich, J.K., Yates, J.R., and Morgan, D.O. (2013) Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat. Struct. Mol. Biol. 20, 194-201. open pdf

Foster, S.A., and Morgan, D.O. (2012) The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol. Cell 47, 921-932. open pdf

Yaakov, G., Thorn, K., and Morgan, D.O. (2012) Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2ACdc55 regulation. Dev. Cell 23, 124-136. open pdf

Lyons, N., and Morgan, D.O. (2011) Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol. Cell 42, 378-389. open pdf

Rodrigo-Brenni, M.C., Foster, S.A., and Morgan, D.O. (2010) Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin. Mol. Cell 39, 548-599. open pdf

Holt, L.J., Tuch, B.B., Villén, J., Johnson, A.D., Gygi, S.P., and Morgan, D.O. (2009) Global analysis of Cdk1 phosphorylation sites provides insights into evolution. Science 325, 1682-1686. open pdf

Matyskiela, M., and Morgan, D.O. (2009) Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol. Cell 34, 68-80. open pdf

Holt, L.J., Krutchinsky, A.N., and Morgan, D.O. (2008) Positive feedback sharpens the anaphase switch. Nature 454, 353-357. open pdf

Enquist-Newman, M., Sullivan M., and Morgan, D.O. (2008) Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol. Cell 30, 437-446. open pdf

Rodrigo-Brenni, M.C., and Morgan, D.O. (2007) Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 130, 127-139. open pdf

Holt, L.J., Hutti, J.E., Cantley, L.C., and Morgan, D.O. (2007) Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol. Cell 25, 689-702. open pdf

Woodbury, E.L., and Morgan, D.O. (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat. Cell Biol. 9, 106-112. open pdf

Loog, M., and Morgan, D.O. (2005) Cyclin Specifically in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104-108. open pdf

Carroll, C.W., Enquist-Newman, M., and Morgan, D.O. (2005) The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr. Biol. 15, 11-18 open pdf

Ubersax, J.A., Woodbury, E.L., Quang, P.N., Paraz, M., Blethrow, J.D., Shah, K., Shokat, K.M., and Morgan D.O. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425, 859-64. open pdf, open supplemental table (Excel), open supplemental table (tab delimited)

Carroll, C.W. and Morgan, D.O. (2002) The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat Cell Biol. 11, 880-7. open pdf

Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., and Shokat, K.M. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401. open pdf

Tinker-Kulberg, R., and Morgan, D.O. (1999) Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and following DNA damage. Genes Dev. 13, 1936-1949. open pdf

Jaspersen, S.L., Charles, J.F., and Morgan, D.O. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227-236. open pdf

Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. (1998) A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9, 2803-2817. open pdf

Espinoza, F.H., Farrell, A., Erdjument-Bromage, H., Tempst, P., and Morgan, D.O. (1996) A major cyclin-dependent-kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 273, 1714-1717. link to journal

Kim, K.-K., Chamberlin, H.M., Morgan, D.O., and Kim, S.-H. (1996) Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nature Structural Biology 3, 849-855.

Fisher, R.P., Jin, P., Chamberlin, H.M., and Morgan, D.O. (1995) Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 83, 47-57.

Fisher, R.P., and Morgan, D.O. (1994) A novel cyclin associates with MO15/CDK7 to form the CDK activating kinase. Cell 78, 713-724.

Gu, Y., Turck, C.W., and Morgan, D.O. (1993) Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710.

De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O., and Kim, S.-H. (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363, 595-602.

Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., and Walter, P. (2015) Molecular Biology of the Cell. 6th edition. New York: Garland Science.

Morgan, D.O. (2007) The Cell Cycle: Principles of Control. London: New Science Press.

Alberts, B., Johnson, A., Lewis, J., Morgan, D., Raff, M., Roberts, K., and Walter, P. (2015) Molecular Biology of the Cell. 6th edition. New York: Garland Science.

Lu, D., Hsiao, J.Y., Davey, N.E., Van Voorhis, V.A., Foster, S.A., Tang, C., and Morgan, D.O. (2014) Multiple mechanisms determine the order of APC/C substrate degradation in mitosis. J. Cell Biol. 207, 23-39

Eshleman, H.D., and Morgan, D.O. (2014) Sgo1 recruits PP2A to chromosomes to ensure sister chromatid bi-orientation in mitosis. J. Cell Sci. 127, 4974-4983

Van Voorhis, V.A., and Morgan, D.O. (2014) Activation of the APC/C ubiquitin ligase by enhanced E2 efficiency. Curr. Biol. 24, 1556-1562

Naylor, S.G., and Morgan, D.O. (2014) Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis. J. Cell Sci. 127, 1128-1137

Lopez, M.S., Choy, J.W., Peters, U., Sos, M.L., Morgan, D.O., and Shokat, K.M. (2013) Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J. Am. Chem. Soc. 135, 18153-18159

Lyons, N.A., Fonslow, B.R., Diedrich, J.K., Yates, J.R., and Morgan, D.O. (2013) Sequential primed kinases create a damage-responsive phosphodegron on Eco1. Nat. Struct. Mol. Biol. 20, 194-201

Foster, S.A., and Morgan, D.O. (2012) The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation. Mol. Cell 47, 921-932

Yaakov, G., Thorn, K., and Morgan, D.O. (2012) Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2ACdc55 regulation. Dev. Cell 23, 124-136

Schaefer, J.B., and Morgan, D.O. (2011) Protein-linked ubiquitin chain structure restricts activity of deubiquitainating enzymes. J. Biol. Chem. 286, 45186-45196

Foe, I.T., Foster, S.A., Cheung, S.K., DeLuca, S.Z., Morgan, D.O., and Toczyski, D.P. (2011) Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanism. Curr. Biol. 21, 1870-1877

Kõivomägi, M., Valk, E., Venta, R., Iofik, A., Lepiku, M., Balog, E.R.M., Rubin, S., Morgan, D.O., and Loog, M. (2011) Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature 480, 128-131

Kõivomägi, M., Valk, E., Venta, R., Iofik, A., Lepiku, M., Morgan, D.O., and Loog, M. (2011) Dynamics of Cdk1 substrate specificity during the cell cycle. Mol. Cell 42, 610-623

Lyons, N., and Morgan, D.O. (2011) Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase. Mol. Cell 42, 378-389

Morgan, D.O. (2010) The hidden rhythms of the dividing cell. Cell 141, 224-226.

Malumbres, M., Harlow, E., Hunt, T., Hunter, T., Lahti, J., Manning, G., Morgan, D.O., Tsai, L.H., and Wolgemuth, D.J. (2009) Cyclin-dependent kinases: a family portrait. Nat. Cell Biol. 11, 1275-1276.

Matyskiela, M.E., Rodrigo-Brenni, M.C., and Morgan, D.O. (2009) Mechanisms of ubiquitin transfer by the anaphase-promoting complex. J. Biol. 8, 92.

Holt, L.J., Tuch, B.B., Villen, J., Johnson, A.D., Gygi, S.P., and Morgan, D.O. (2009) Global analysis of Cdk1 phosphorylation sites provides insights into evolution. Science 325, 1682-1686.

Matyskiela, M., and Morgan, D.O. (2009) Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism. Mol. Cell 34, 68-80.

Benanti, J.A., Matyskiela, M.E., Morgan, D.O., and Toczyski, D.P. (2009) Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol. Cell 33, 581-590.

Tully, G.H., Nishihama, R., Pringle, J.R., and Morgan, D.O. (2009) The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol. Biol. Cell 20, 1201-1212.

Sullivan, M., Holt, L.J., and Morgan, D.O. (2008) Cyclin-specific control of ribosomal DNA segregation. Mol. Biol. Cell 28, 5328-5336.

Holt, L.J., Krutchinsky, A.N., and Morgan, D.O. (2008) Positive feedback sharpens the anaphase switch. Nature 454, 353-357.

Enquist-Newman, M., Sullivan M., and Morgan, D.O. (2008) Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1. Mol. Cell 30, 437-446.

Ko, N., Nishihama, R., Tully, G.H., Ostapenko, D., Solomon, M.J., Morgan, D.O., and Pringle, J.R. (2007) Identification of yeast IQGAP (Iqg1p) as an anaphase-promoting-complex substrate and its role in actomyosin-ring-independent cytokinesis. Mol. Biol. Cell 18, 5139-5153.

Snead, J.L., Sullivan, M., Lowery, D.M., Cohen, M.S., Zhang, C., Randle, D.H., Taunton, J., Yaffe, M.B., Morgan, D.O., and Shokat, K.M. (2007) A coupled chemical-genetic and bioinfomatic approach to Polo-like kinase pathway exploration. Chem. & Biol. 14, 1261-1272.

Sullivan, M., and Morgan, D.O. (2007) Finishing mitosis, one step at a time. Nat. Rev. Mol. Cell Biol. 8, 894-903.

Woodbury, E.L., and Morgan, D.O. (2007) The role of self-association in Fin1 function on the mitotic spindle. J. Biol. Chem. 283, 32138-32143.

Goga, A., Tward, A., Morgan, D.O., and Bishop, J.M. (2007) Inhibition of Cdk1 as a potential therapy for tumors over-expressing MYC. Nature Medicine 13, 820-827.

Rodrigo-Brenni, M.C., and Morgan, D.O. (2007) Sequential E2s drive polyubiquitin chain assembly on APC targets. Cell 130, 127-139.

Sullivan, M., and Morgan, D.O. (2007) A novel destruction sequence targets the meiotic regulator Spo13 for APC-dependent degradation in anaphase I. J. Biol. Chem. 282, 19710-19715.

Holt, L.J., Hutti, J.E., Cantley, L.C., and Morgan, D.O. (2007) Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Mol. Cell 25, 689-702.

Woodbury, E.L., and Morgan, D.O. (2007) Cdk and APC activities limit the spindle-stabilizing function of Fin1 to anaphase. Nat. Cell Biol. 9, 106-112.

Morgan, D.O. (2007) The Cell Cycle: Principles of Control. London: New Science Press.

Thornton, B.R., Ng, T.M., Matyskiela, M.E., Carroll, C.W., Morgan, D.O., and Toczyski, D.P. (2006) An architectural map of the anaphase-promoting complex. Genes Dev. 20, 449-460.

Carroll, C.W., and Morgan, D.O. (2005) Enzymology of the Anaphase-Promoting Complex. Meth. Enzymol. 398, 219-230.

Loog, M., and Morgan, D.O. (2005) Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature 434, 104-108.  (Commentary: Nature 434, 34-35; and Nat. Rev. Mol. Cell Biol. 6, 280)

Carroll, C.W., Enquist-Newman, M., and Morgan, D.O. (2005) The APC subunit Doc1 promotes recognition of the substrate destruction box. Curr. Biol. 15, 11-18.

Ubersax, J.A., Woodbury, E.L., Quang, P.N., Paraz, M., Blethrow, J.D., Shah, K., Shokat, K.M., and Morgan, D.O. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature, 425, 859-864.

Carroll, C.W., and Morgan, D.O. (2002) The Doc1 subunit is a processivity factor for the anaphase-promoting complex. Nat. Cell Biol. 4, 880-887.

Kraybill, B.C., Elkin, L.L., Blethrow, J.D., Morgan, D.O., and Shokat, K.M. (2002) Inhibitor scaffolds as new allele-specific kinase substrates. J. Amer. Chem. Soc. 124, 12118-12128.

Morgan, D.O., and Roberts, J.M. (2002) Cell cycle: oscillation sensation. Nature 418, 495-496 (news and views article).

Polson, A.G., Huang, L., Lukac, D.M., Blethrow, J.D., Morgan, D.O., Burlingame, A.L., and Ganem, D. (2001) Kaposi’s sarcoma-associated herpesvirus K-bZIP protein is phosphorylated by cyclin-dependent kinases. Mol. Cell. Biol. 75, 3175-3184.

Garrett, S., Barton, W.A., Knights, R., Jin, P., Morgan, D.O., and Fisher, R.P. (2001) Reciprocal activation by CDK2 and CDK7 is directed by substrate specificity determinants outside the T-loop. Mol. Cell Biol. 21, 88-99.

Takizawa, C.G., and Morgan, D.O. (2000) Control of mitosis by changes in the subcellular location of cyclin B1-Cdk1 and Cdc25C. Curr. Opin. Cell Biol. 12, 658-665.

Bishop, A.C., Ubersax, J.A., Petsch, D.T., Matheos, D., Gray, N.S., Blethrow, J., Shimizu, E., Tsien, J.Z., Schultz, P.G., Rose, M.D., Wood, J.L., Morgan, D.O., and Shokat, K.M. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401.

Jaspersen, S.L., and Morgan, D.O. (2000) Cdc14 activates Cdc15 to promote mitotic exit in budding yeast. Curr. Biol. 10, 615-618.

Farrell, A., and Morgan, D.O. (2000) Cdc37 promotes the stability of protein kinases Cdc28 and Cak1. Mol. Cell. Biol. 20, 749-54.

Liu, Y., Bishop, A., Witucki , L., Kraybill , B., Shimizu , E., Tsien, J., Ubersax, J., Blethrow, J., Morgan, D.O., and Shokat, K.M. (1999) Structural basis for selective inhibition of Src family kinases by PP1. Chem. & Biol. 6, 671-678.

Tinker-Kulberg, R., and Morgan, D.O. (1999) Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and following DNA damage. Genes Dev. 13, 1936-1949.

Takizawa, C.G., Weis, K., and Morgan, D.O. (1999) Ran-independent nuclear import of cyclin B1-Cdc2 by importin-b. Proc. Natl. Acad. Sci. USA 96, 7938-7943.

Morgan, D.O. (1999) The regulation of the APC and the exit from mitosis. Nature Cell Biology 1, E47-E53.

Jaspersen, S.L., Charles, J.F., and Morgan, D.O. (1999) Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14. Curr. Biol. 9, 227-236.

Espinoza, F.H., Farrell, A., Nourse, J.L., Chamberlin, H.M., Gileadi, O., and Morgan, D.O. (1998) Cak1 is required for Kin28 phosphorylation and activation in vivo. Mol. Cell. Biol. 18, 6365-6373.

Jaspersen, S.L., Charles, J.F., Tinker-Kulberg, R.L., and Morgan, D.O. (1998) A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol. Biol. Cell 9, 2803-2817.

Gray, N.S., Wodicka, L., Thunnissen, A.-M.W.H., Norman, T.C.,  Kwon, S., Espinoza, F.H., Morgan, D.O., Barnes, G., LeClerc, S., Meijer, L., Kim, S.-H., Lockhart, D.J., and Schultz, P. (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281, 533-538.

Jin, P., Hardy, S., and Morgan, D.O. (1998) Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141, 875-885.

Charles, J.F., Jaspersen, S.L., Tinker-Kulberg, R., Hwang, L., Szidon, A., and Morgan, D.O. (1998) The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae. Curr. Biol. 8, 497-507.

Morgan, D.O. (1997) Cyclin-dependent kinases: engines, clocks and microprocessors. Annu. Rev. Cell Dev. Biol. 13, 261-291.

Cujec, T. P., Okamoto, H., Fujinaga, K., Meyer, J., Chamberlin, H., Morgan, D.O., and Peterlin, B.M. (1997) The HIV transactivator TAT binds to the CDK-activating kinase and activates the phosphorylation of the carboxy-terminal domain of RNA polymerase II. Genes Dev. 11, 2645-2657.

Morgan, D.O. (1996) The dynamics of cyclin dependent kinase structure. Curr. Opin. Cell Biol. 8, 767-772.

Kim, K.-K., Chamberlin, H.M., Morgan, D.O., and Kim, S.-H. (1996) Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nature Structural Biology 3, 849-855.

Espinoza, F.H., Farrell, A., Erdjument-Bromage, H., Tempst, P., and Morgan, D.O. (1996) A major cyclin-dependent-kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 273, 1714-1717.

Jin, P., Gu, Y., and Morgan, D.O. (1996) Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells. J. Cell Biol. 134, 963-970.

Fisher, R.P., and Morgan, D.O. (1996) CAK in TFIIH: Crucial Connection or Confounding Coincidence? BBA Reviews on Cancer Online , June 1996; printed in Biochim. Biophys. Acta 1288, O7-O10.

Morgan, D.O. (1996) Under arrest at atomic resolution. Nature 382, 295-296 (news and views article).

He, J., Choe, S.,  Walker, R., DiMarzio, P., Morgan, D.O., and Landau, N.R. (1995) Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69, 6705-6711.

Fisher, R.P., Jin, P., Chamberlin, H.M., and Morgan, D.O. (1995) Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 83, 47-57.

Schulze-Gamen, U., Brandsen, J., Jones, H.D., Morgan, D.O., Meijer, L., Vesely, J. & Kim, S.-H. (1995) Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine. Proteins 22, 378-391.

Kaplan, K.B., Swedlow, J.R., Morgan, D.O., and Varmus, H.E. (1995) c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism. Genes Dev. 9, 1505-1517.

Gerber, M.R., Farrell, A., Deshaies, R.J., Herskowitz, I., and Morgan, D.O. (1995) Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Proc. Natl. Acad. Sci. USA 92, 4651-4655.

Shiekhattar, R., Mermelstein, F., Fisher, R.P., Drapkin, R., Dynlacht, B., Wessling, H.C., Morgan, D.O., and Reinberg, D. (1995) Cdk-activating kinase (CAK) complex is a component of human transcription factor IIH. Nature 374, 283-287.

Morgan, D.O. (1995) Principles of CDK regulation. Nature 374, 131-134.

Desai, D., Wessling, H.C., Fisher, R.P., and Morgan, D.O. (1995) Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2. Mol. Cell. Biol. 15, 345-350.

Espinoza, F.H., Ogas, J., Herskowitz, I., and Morgan, D.O. (1994) Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85. Science 266, 1388-1391.

Matsuoka, M., Kato, J., Fisher, R.P., Morgan, D.O., and Sherr, C.J. (1994) Activation of cyclin-dependent kinase-4 (CDK4) by mouse MO15-associated kinase. Mol. Cell Biol. 14, 7265-7275.

Kaplan, K. B., Bibbins, K.B., Swedlow, J.R., Arnaud, M., Morgan, D.O., and Varmus, H.E. (1994) Association of the amino terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of Tyr 527. EMBO J. 13, 4745-4756.

Fisher, R.P., and Morgan, D.O. (1994) A novel cyclin associates with MO15/CDK7 to form the CDK activating kinase. Cell 78, 713-724.

Grana, X., De Luca, A., Fu, Y., Claudio, P.P., Rosenblatt, J., Morgan, D.O., and Giordano, A. (1994) PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc. Natl. Acad. Sci. USA 91, 3834-3838.

Morgan, D.O., and De Bondt, H. (1994) Protein kinase regulation: insights from crystal structure analysis. Curr. Opin. Cell Biol. 6, 239-246.

Mittnacht, S., Lees, J.A., Desai, D., Harlow, E., Morgan, D.O., and Weinberg, R.A. (1994) Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 13, 118-127.

Gu, Y., Turck, C.W., and Morgan, D.O. (1993) Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710.

Murphy, S.M., Bergman, M., and Morgan, D.O. (1993) Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae. Mol. Cell. Biol. 13, 5290-5300.

De Bondt, H.L., Rosenblatt, J., Jancarik, J., Jones, H.D., Morgan, D.O., and Kim, S.-H. (1993) Crystal structure of cyclin-dependent kinase 2. Nature 363, 595-602.

Rosenblatt, J., De Bondt, H., Jancarik, J., Morgan, D.O., and Kim, S.-H. (1993) Purification and crystallization of human cyclin-dependent kinase 2. J. Mol. Biol. 230, 1317-1319.

Gu, Y., Rosenblatt, J., and Morgan, D.O. (1992) Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11, 3995-4005.

Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J.W., Elledge, S., Nishimoto, T., Morgan, D.O., Franza, B.R., and Roberts, J.M. (1992) Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257, 1689-1694.

Kaplan, K.B., Swedlow, J., Varmus, H.E., and Morgan, D.O. (1992) Association of p60c-src with endosomal membranes in mammalian fibroblasts. J. Cell Biol. 118, 321-333.

Desai, D., Gu, Y., and Morgan, D.O. (1992) Activation of human cyclin-dependent kinases in vitro. Mol. Biol. Cell  3, 571-582.

Morgan, D.O. (1992) Cell cycle control in normal and neoplastic cells. Curr. Opin. Genetics Develop. 2, 33-37.

Rosenblatt, J., Gu, Y., and Morgan, D.O. (1992) Human cyclin-dependent kinase 2 is activated early in the cell cycle and associates with Cyclin A. Proc. Natl. Acad. Sci. USA 89, 2824-2828.

Morgan, D.O., Kaplan, J.M., Bishop, J.M., and Varmus, H.E. (1991) Production of p60c-src by baculovirus expression and immunoaffinity purification. Meth. Enz. 200, 645-660.

Varmus, H., Hirai, H., Morgan, D., Kaplan, J., and Bishop J.M. (1989) Function, location, and regulation of the src protein-tyrosine kinase. International Symposium of the Princess Takamatsu Cancer Research Fund 20, 63-70.

Morgan, D.O., Kaplan, J.M., Bishop, J.M., and Varmus, H.E. (1989) Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase. Cell  57, 775-786.

Rutter, W.J., Morgan, D.O., Ebina, Y., Wang, L.-H., Roth, R.A., and Ellis, L. (1988) Membrane linked insulin receptor tyrosine kinase stimulates the insulin specific response. In:  Goren, H.J., Hollenberg, M.D., & Roncari, D.K. (eds) Insulin Action and Diabetes, Raven Press, New York, pp. 1-12.

Roth, R.A., Morgan, D.O., and Shii, K. (1988) Monoclonal antibodies as probes of insulin action and degradation. In: Insulin Receptors, Part A: Methods for the Study of Structure and Function (eds. C.R.Kahn and L.C.Harrison). Alan R. Liss. pp 111-121.

Morgan, D.O. and Roth, R.A. (1988) Analysis of intracellular enzyme function by antibody injection. Immunology today  9, 84-88.

Morgan, D.O., Edman, J.C., Standring, D.N., Fried, V.A., Smith, M.C., Roth, R.A., and Rutter, W.J. (1987) Insulin-like growth factor II receptor as a multifunctional binding protein. Nature  329, 301-307.

Roth, R..A., Stover, C., Hari, J., Morgan, D.O., Smith, M.C., Sara, V., and Fried, V.A. (1987) Interactions of the receptor for insulin-like growth factor II with mannose-6-phosphate and antibodies to the mannose-6-phosphate receptor. Biochem. Biophys. Res. Comm. 149, 600-606.

Hari, J., Pierce, S.B., Morgan, D.O., Sara, V., Smith, M.C., and Roth, R.A. (1987) The receptor for insulin-like growth factor II mediates an insulin-like response. EMBO J. 6, 3367-3371.

Clauser, E., Ellis, L., Morgan, D., Edery, M., Roth, R.A., and Rutter, W.J. (1987) The human insulin receptor cDNA: a new tool for the study of this receptor. J. Receptor Research 7, 377-404.

Ellis, L., Morgan, D.O., Clauser, E., Edery, M., Jong, S.-M., Wang, L.-H., Roth, R.A., and Rutter, W.J. (1987) Mechanisms of receptor-mediated transmembrane communication. Cold Spring Harbor Symposia on Quantitative Biology  51, 773-784.

Ellis, L., Morgan, D.O., Jong, S.-M., Wang, L.-H., Roth, R.A., and Rutter, W.J. (1987) Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. USA  84, 5101-5105.

Morgan, D.O., Ellis, L., Rutter, W.J., and Roth, R.A. (1987) Antibody-induced down-regulation of a mutated insulin receptor lacking an intact cytoplasmic domain. Biochemistry  26, 2959-2963.

Morgan, D.O., and Roth, R.A. (1987) Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin. Proc. Natl. Acad. Sci. USA  84, 41-45.

Ellis, L., Morgan, D.O., Clauser, E., Roth, R.A., and Rutter, W.J. (1987) A truncated membrane-anchored human insulin receptor expressed in CHO cells mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose. Molecular Endocrinology  1, 15-24.

Roth, R.A., Morgan, D.O., Beaudoin, J., and Sara, V. (1986) Purification and characterization of the human brain insulin receptor. J.Biol.Chem. 261, 3753-3757.

Shimizu, M., Webster, C., Morgan, D.O., and Roth, R.A. (1986) Insulin and insulin-like growth factor receptors and responses in cultured human muscle cells. Amer. J. Physiol. 251, E611-E615.

Morgan, D.O., and Roth, R.A. (1986) Identification of a monoclonal antibody which can distinguish between two distinct species of the type I receptor for insulin-like growth factor. Biochem. Biophys. Res. Commun. 138, 1341-1347.

Morgan, D.O., Jarnagin, K., and Roth, R.A. (1986) Purification and characterization of the receptor for insulin-like growth factor I. Biochemistry  25, 5560-5564.

Ellis, L., Morgan, D.O., Koshland, D.E. Jr., Clauser, E., Moe, G., Bollag, G., Roth, R.A., and Rutter, W.J. (1986) The linking of functional domains of the human insulin receptor with bacterial aspartate receptor. Proc. Natl. Acad. Sci. USA 83, 8137-8141.

Ellis, L., Clauser, E., Morgan, D.O., Edery, M., Roth, R.A., and Rutter, W.J. (1986) Replacement of insulin receptor tyrosine residues (1162 and 1163) by site-directed mutagenesis compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell  45, 721-732.

Morgan, D.O., and Roth, R.A. (1986) Mapping surface structures of the human insulin receptor with monoclonal antibodies: localization of the main immunogenic regions to the receptor kinase domain. Biochemistry  25, 1364-1371.

Morgan, D.O., Ho, L., Korn, L.J., and Roth, R.A. (1986) Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proc.Natl.Acad.Sci.USA 83, 328-332.

Roth., R.A., and Morgan, D.O. (1985) Monoclonal antibodies to the insulin receptor. Pharmac.Ther. 28, 1-16.

Morgan, D.O., and Roth, R.A. (1985) Plate binding assay for monoclonal anti-receptor antibodies. Endocrinology 116, 1224-1226.

Roth, R.A., Morgan, D.O., and Masaracchia, R.A. (1985) Monoclonal antibodies as probes of the structure and function of the insulin receptor. Cancer Cells 3: Growth Factors and Transformation (Cold Spring Harbor Symp.) pp.109-113.

Roth, R.A., Cassell, D.J., Morgan, D.O., Tatnell, M.A., Jones, R.H., Schuttler, A., and Brandenburg, D. (1984) Effects of covalently linked insulin dimers on receptor kinase activity and receptor down regulation. F.E.B.S.Lett. 170, 360-364.

Gerritsen, M.E., Morgan, D.O., Parks, T.P., Printz, M.P., and Lederis, K.P. (1982) A proposed role for prostaglandins in the modulation of the relaxation response to urotensin I in isolated rat arteries. Prostaglandins 22, 873-892.

Morgan, D.O., and McMahon, B.R. (1982) Acid tolerance and effects of sublethal acid exposure on iono-regulation and acid-base status in two crayfish Procambarus clarki and Orconectes rusticusJ.Exp.Biol. 97, 241-252.

Goren, H.J., Geonzon, R.M., Hollenberg, M.D., Lederis, K., and Morgan, D.O. (1980) Oxytocin action: lack of correlation between receptor number and tissue responsiveness. J.Supramol.Structure 14, 129-138.

 

 


 

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