Experiment: Intracranial Self Administration (SA)

Nucleus Accumbens (NAc)

Self-administeration of amphetamine into NAc. When cannula shifted to ventricles, the response was extinguished.

Hoebel BG, Monaco AP, Hernandez L, Aulisi EF, Stanley BG, Lenard L
Self-injection of amphetamine directly into the brain. Psychopharmacology (Berl). 1983;81(2):158-63. Abstract.

Medial Prefrontal Cortex (mPFC)

As part of a study looking at the pharmacology of cocaine self-administeration into mPFC, authors showed that d-Amphetamine is not self-administered there. [See also Carr et al (1986) below].

Goeders et al., (1986)
Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex. Pharmacol Biochem Behav. 1986 May;24(5):1429-40. Abstract.

Nucleus Accumbens (NAc), Medial Prefrontal Cortex (mPFC), Amygdala (Amyg)

Amphetamine CPP with microinjections into NAc but not mPFC or Amygdala

Carr et al., (1986)
Anatomical disassociation of amphetamine's rewarding and aversive effects: an intracranial microinjection study. Psychopharmacology (Berl). 1986;89(3):340-6. Abstract.