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S E L E C T    P U B L I C A T I O N S   (by year)

2010 2011 2012 2013 2014
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
1990 1991 1992 1993 1994 1995 1996 1997 1998 1999
1974-1979 1980-1986 1987 1988 1989

2014

  • Han, C., Song, Y., Wang, D., Franc, N.C., Jan, L.Y., and Jan, Y.N. (2014) Epidermal Cells are the Primary Phagocytes in the Fragmentation and Clearance of Degenerating Dendrites in Drosophila. Neuron 81:544-60. PMID: 24412417. [PDF]

  • Yuan, Q., Song Y., Yang, C.H, Jan, L.Y., and Jan, Y.N. (2014). Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila, Nature Neurosci. 17:81-8. PMID: 24241395. [PubMedCentral]

2013

  • Isacoff, E.Y., Jan, L.Y., Minor, D.L. Jr. (2013) Conduits of life’s spark: a perspective on ion channel research since the birth of neuron. Neuron 80:658-74. PMCID: PMC3867263. [PubMedCentral]

  • Kim, W.J., Jan, L.Y., and Jan, Y.N. (2013). A PDF/NPF Neuropeptide Signaling Circuitry of Male Drosophila melanogaster Controls Rival-Induced Prolonged Mating. Neuron 80:1190-205. PMCID: PMC3867312. [PubMedCentral]

  • Wong, X. M., Younger, S., Peters, C.J., Jan, Y.N., and Jan, L.Y. (2013). Subdued, a TMEM16 family Ca2+-activated Cl- channel in Drosophila melanogaster with an unexpected role in host defense. eLife 2:e00862. PMCID: PMC3814000. [PubMedCentral]

  • Sun, Y., Dong, Z., Jin, T., Ang, K.H., Huang, M., Haston, K.M., Peng, J., Zhong, T.P., Finkbeiner, S., Weiss, W.A., Arkin, M.R., Jan, L.Y., and Guo, S. (2013) Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. eLife 2:e00508. PMCID: PMC3771564 [PubMedCentral]

  • Han, T.W., and Jan, L.Y. (2013) Making antisense of pain. Nat Neurosci 16:986-7. PMID: 23887131. [PubMedCentral]

  • Zhang, W., Yan, Z., Jan, L.Y., and Jan, Y.N. (2013) Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. PNAS USA 110:13612-7. PMCID: PMC3746866. [PubMedCentral]

  • Huang, F., Wang, X., Ostertag, E.M., Nuwal, T., Huang, B., Jan, Y.N., Basbaum, A.I., and Jan, L.Y. (2013) TMEM16C facilitates Na+-activated K+ currents in rat sensory neurons and regulates pain processing. Nat Neurosci. 16:1284-90. PMID: 23872594. [PubMedCentral]

  • Tien, J., Lee, H.Y., Minor, D.L. Jr., Jan, Y.N., and Jan, L.Y. (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). PNAS USA 110:6352-7. PMID: 23576756. [PubMedCentral]

  • Thayer, D.A., Jan, Y.N., Jan, L.Y. (2013) Increased neuronal activity fragments the Golgi complex. PNAS USA 2013 Jan 7. PMID: 23297202. [PubMedCentral]

  • Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L.E., Meltzer, S., Jan, L.Y., and Jan, Y.N. (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493:221-5. PMID: 23222543. [PubMedCentral]

2012

  • Ori-McKenney, K.M., Jan, L.Y., and Jan, YN. (2012) Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron 76:921-30. PMCID: PMC3523279 [PubMedCentral]

  • Fieni, F., Bae Lee, S., Jan, Y.N., and Kirichok, Y. (2012) Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 3:1317. PMID: 23271651. [PubMedCentral]

  • Yang, H., Kim, A., David, T., Palmer, D., Jin, T., Tien, J., Huang, F., Cheng, T., Coughlin, S.R., Jan, Y.N., and Jan, L.Y. (2012) TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation. Cell 151:111-22. PMID: 23021219. [PubMedCentral]

  • Huang, F., Zhang, H., Wu, M., Yang, H., Kudo, M., Peters, C.J., Woodruff, P.G., Solberg, O.D., Donne, M.L., Huang, X., Sheppard, D., Fahy, J.V., Wolters, P.J., Hogan, B.L., Finkbeiner, W.E., Li, M., Jan, Y.N., Jan, L.Y., Rock, J.R. (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. PNAS USA 109:16354-9. PMCID: PMC3479591. [PubMedCentral]

  • Huang, X., Dubuc, A.M., Hashizume, R., Berg, J., He, Y., Wang, J., Chiang, C., Cooper, M.K., Northcott, P.A., Taylor, M.D., Barnes, M.J., Tihan, T., Chen, J., Hackett, C.S., Weiss, W.A., James, C.D., Rowitch, D.H., Shuman, M.A., Jan, Y.N., and Jan, L.Y. (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 26:1780-96. PMID: 22855790. [PubMedCentral]

  • Yang, S.B., Tien, A.C., Boddupalli, G., Xu, A.W., Jan, Y.N., and Jan, L.Y. (2012) Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons. Neuron 75: 425-436. PMID: 22884327. [PubMedCentral]

  • Yang, S.B., Lee, H.Y., Young, D.M., Tien, A.C., Rowson-Baldwin, A., Shu, Y.Y., Jan, Y.N., Jan, L.Y. (2012) Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med 90:575-85. PMCID: PMC3354320. [PubMedCentral]

  • Song, Y., Ori-McKenney, K.M., Zheng, Y., Han, C., Jan, L.Y., and Jan, Y.N. (2012). Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26:1612-1625. PMID: 22759636. [PDF]

  • Berg, J., Yang, H., and Jan, L.Y. (2012) Ca2+-activated Cl-channels at a glance. J. Cell Sci. 125:1367-1371. PMCID: PMC3336373. [PDF]

  • Jan, Y.N. (2012) Yoshiki Hotta's influence. J Neurogenet. 26:3-4. PMID:22263807. [PDF]

  • Kim, W.J., Jan, L.Y., and Jan, Y.N. (2012) Contribution of Visual and Circadian Neural circuits to Memory for Prolonged Mating induced by Rivals. Nature Neurosci. 15:876–883. PMID:22561453. [PubMedCentral]

  • Huang, W.C, Xiao, S., Huang, F., Harfe, B.D., Jan, Y.N., and Jan, L.Y. (2012) Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons. Neuron 74:179-192. PMID: PMC3329964. [PDF]

  • Lee, H.Y., and Jan, L.Y. (2012) Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels. Curr Opin Neurobiol. PMID: 22483378. [PubMedCentral]

  • Jan, L.Y., and Jan, Y.N. (2012) Voltage-gated potassium channels and the diversity of electrical signalling. J Physiol. 590:2591-9. PMID: 22431339. [PubMedCentral]

  • Ge, W.P., Miyawaki, A., Gage, F.H., Jan, Y.N., and Jan, L.Y. (2012) Local generation of glia is a major astrocyte source in postnatal cortex. Nature. PMID: 22456708. [PubMedCentral]

  • Yang, S.B., Mclemore, K.D.,Tasic, B., Luo, L., Jan, Y.N., and Jan, L.Y. (2012) Kv1.1-dependent Control of Hippocampal Neuron Number as Revealed by Mosaic Analysis with Double Markers (MADM). J Physiol. 590:2645-58. PMID: 22411008. [PubMedCentral]

  • Ultanir, S.K., Hertz, N.T., Li, G., Ge, W.P., Burlingame, A.L., Pleasure, S.J., Shokat, K.M., Jan, L.Y., and Jan, Y.N. (2012) Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development. Neuron 73:1127-1142. PMID: 22445341. [PDF]

  • Han, C., Wang, D., Soba, P., Zhu, S., Lin, X., Jan, L.Y., and Jan, Y.N. (2012) Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron 73:64-78. PMCID: PMC3269260. [PubMedCentral]

  • Huang, F., Wong, X., and Jan, L.Y. (2012) International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels. Pharmacol Rev 64:1-15. PMID: 22090471. [PDF]

2011

  • Zhu, S., Barshow, S., Wildonger, J., Jan, L.Y., and Jan, Y.N. (2011). Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains. PNAS USA 108: 20615-20. PMCID: PMC3251047 [PubMedCentral]

  • Lee, H.Y., Ge, W.P., Huang, W., He, Y., Wang, G.X., Rowson-Baldwin, A., Smith, S.J., Jan, Y.N., and Jan, L.Y. (2011) Bidirectional Regulation of Dendritic voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein. Neuron 72:630-642. PMCID: PMC3433402. [PDF]

  • Lee, S.B., Bagley, J.A., Lee, H.Y., Jan, L.Y., and Jan, Y.N. (2011) Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila. Proc Natl Acad Sci USA 108:16795-16800. PMID: 21930920 [PDF]

  • Yuan, Q., Xiang, Y., Yan, Z., Han, C., Jan, L.Y., and Jan, Y.N. (2011) Light-induced structural and functional plasticity in Drosophila larval visual system. Science 333:1458-62. PMID: 21903815. [PDF]

  • Rumpf, S., Lee, S.B., Jan, L.Y. and Jan, Y.N. (2011) Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development 138:1153-1160. PMCID: PMC3042870. [PDF]

  • Ye, B., Kim, J.H., Yang, L.M., McLachlan, I., Younger, S., Jan, L.Y. and Jan, Y.N. (2011) Differential regulation of dendritic and axonal development by the novel Kruppel-like factor Dar1. J. Neurosci. 31:3309-3319. PMCID: PMC3086283. [PDF]

  • Ouyang, Y., Petritsch, C., Wen, H., Jan, L., Jan, Y.N., and Lu, B. (2011) Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development 138:2185-96. PMCID: PMC3091490. [PubMedCentral]

  • Han, C., Jan, L.Y., and Jan, Y.N. (2011) Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A. 108:9673-8. PMCID: PMC3111288. [PubMedCentral]

2010

  • Xiang, Y., Yuan, Q., Vogt, N., Looger, L.L., Jan, L.Y., and Jan, Y.N. (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468:921-926. PMCID: PMC3026603. [PDF]

  • Thayer, D.A., and Jan, L.Y. (2010) Mechanisms of distribution and targeting of neuronal ion channels. Curr Opin Drug Discov Devel. 13:559-567. PMID: 20812147. [PubMedCentral]

  • Cheng, L.E., Song, W., Looger, L.L., Jan, L.Y., and Jan, Y.N. (2010) The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion. Neuron. 67:373-380. PMCID: PMC2933178. [PDF]

  • Young, DM., Schenk, AK., Yang, SB., Jan, YN., Jan, LY. (2010) Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc Natl Acad Sci USA. 107:11074-11079. PMCID: PMC2890736 [PubMedCentral]

  • Zhou, W., Jan, LY. (2010) A Twist on Potassium Channel Gating. Cell 141(6):920-22. PMID: 20550927. [PDF]

  • Jan, Y.N., and Jan, L.Y. (2010) Branching out: mechanisms of dendritic arborization. Nat. Rev. Neurosci. 11:316-328. PMCID: PMC3079328. [PDF]

2009

  • Yang, C., Rumpf, S., Xiang, Y., Gordon, M.D., Song, W., Jan, LY., Jan, YN. (2009) Control of the postmating behavioral switch in Dropsophila females by internal sensory neurons. Neuron 61 (4):519-526. PMID: 19249273 [PubMed]

  • Xiao, S.H., and Jan, L.Y. (2009) A gate keeper for axonal transport. Cell 136(6):996-998. PMID: 19303842 [PubMed]

  • Parrish, J.Z., Xu, P., Kim, K.C., Jan, L.Y., and Jan, Y.N. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in Drosophila sensory neurons. Neuron 63:788-802.  PMID: 19778508. [PubMed]

  • Lee, H.H., Jan, L.Y., and Jan, Y.N. (2009) Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci, USA. 106:6363-8. PMID: 19329489 [PubMedCentral]

  • Kim, M.D., Wen, Y., Jan, Y.N. (2009) Patterning and organization of motor neuron dendrites in the Drosophila larva. Dev Biol. 336:213-21. PMID: 19818341 [PubMedCentral]

  • Huang, F., Rock, J.R., Harfe, B.D., Cheng, T., Huang, X., Jan, Y.N., Jan, L.Y. (2009) Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci USA 106:21413-8. PMCID: 2781737 [PubMedCentral]

  • Ge, WP., Zhou, W., Luo, Q., Jan, LY., Jan, YN. (2009) Dividing glial cells maintain diffentiated properties including complex morphology and functional synapses. Proc Natl Acad Sci USA. 106(1):328-33. PMCID: PMC2610014 [PubMedCentral]

  • Chung, HJ., Qian, X., Ehlers, M., Jan, YN., Jan, LY. (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci USA. 106(2):629-34. PMCID: 2613039 [PubMedCentral]

  • Chung, HJ., Ge, WP., Qian, X., Wiser, O., Jan, YN., Jan, LY. (2009) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term protentiation. Proc Natl Acad Sci USA. 106(2):635-40. PMCID: PMC2613041 [PubMedCentral]

  • Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.H. (2009) Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 63:189-202. PMCID: PMC2736606 [PubMedCentral]

2008

  • Sokol, S.N., Xu, P., Jan, Y.N., and Ambros, V. (2008). Dropsophila let-7 micro RNA is required for remodeling of the neuromusculature during metamorphosis. Genes & Dev. 22:1591-1596. PMCID: PMC2428057 [PubMedCentral]

  • Schroeder, B.C., Cheng, T., Jan, Y.N., Jan, L.Y. (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134 (6): 1019-1029. PMCID: PMC2651354 [PubMedCentral]

  • Yang, C.H., Belawat, P., Hafen, E., Jan, L.Y. and Jan, Y.N. (2008). Drosophila egg-layng site selection as a system to study simple decision-making processes. Science 319:1679-1683. PMCID: PMC2581776 [PubMedCentral]

  • Wildonger, J., Jan, L.Y., Jan, Y.N. (2008) The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Genes Dev. 22: 2447-2453. PMID: 18794342[PubMed]

  • Jan, Y.N. and Jan., L. (2008). Retrospective: Seymour Benzer (1921-2007). Science 319:45. PMID: 18174427 [PubMed]

  • Yang, S.B., and Jan, L.Y. (2008) Thrilling moment of an inhibitory channel. Neuron 58:823-824. PMID: 18579071 [PubMed]

  • Chi, N.C., Shaw, R.M., De Val, S., Kang, G., Jan, L.Y., Black, B.L., and Stainier, D.Y.R. (2008). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & Development 22:734-739. PMCID: PMC2275426 [PubMedCentral]

  • Chi, N.C., Shaw, R.M., Jungblut, B., Ferrer, T., Aarnaout, R., Scott, I., Beis, D., Xiaao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M. and Stainier, D.Y.R. (2008). Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biology 13:6(5): e109. PMCID: PMC2430899 [PubMedCentral]

  • Zheng, Y, Wildonger, J., Ye, B., Zhang, Y., Kita, A., Younger, S.H., Zimmerman, S., Jan, L.Y., Jan, Y.N.(2008) Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat Cell Biol. 10:1172-1180. PMID: 18758451 [PubMed]

  • Huang, J., Zou, W., Watson, A., Jan, Y.N., Hong, Y. (2008) Efficient Ends-Out GeneTargeting In Drosophilia. Genetics 180: 703-707. PMCID: PMC2535722 [PubMedCentral]

 

 

2007

  • Ye, B., Zhang, Y., Song, W., Younger, S.H., Jan, L.Y., and Jan, Y.N. (2007). Growing dendrites and axons differ in their reliance on the secretory pathway. Cell 130:717-729. PMCID: PMC2020851 [PubMedCentral]

  • Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S.J., Yu, H.H., Lee, T., Jan, L.Y., and Jan, Y.N. (2007). Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron 54:403-416. PMCID: PMC1963441  [PubMedCentral]

  • Parrish, J.Z., Emoto, K., Kim, M.D., and Jan, Y.N. (2007). Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu. Rev. Neurosci. 30:399-423. PMID: 17378766 [PubMed]

  • Parrish, J.Z., Emoto, K., Jan, L.Y., and Jan, Y.N. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21:956-972. PMCID: PMC1847713  [PubMedCentral]

  • Song, W., Onishi, M., Jan, L.Y., and Jan, Y.N. (2007). Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Proc Natl Acad Sci U S A. 104:5199-5204. PMCID: PMC1820883 [PubMedCentral]

  • Grueber, W.B., Ye, B., Yang, C.H., Younger, S., Borden, K., Jan, L.Y., and Jan, Y.N. (2007). Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 134:55-64. PMID: 17164414  [PubMed] Final Version Available Free

  • Koo, B.K., Yoon, M.J., Yoon, K.J., Im, S.K., Kim, Y.Y., Kim, C.H., Suh, P.G., Jan, Y.N., and Kong, Y.Y. (2007). An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS ONE. 2:e1221. PMCID: PMC2082076 [PubMedCentral]

  • Rasin, M.R., Gazula, V.R., Breunig, J.J., Kwan, K.Y., Johnson, M.B., Liu-Chen, S., Li, H.S., Jan, L.Y., Jan, Y.N., Rakic, P., and Sestan, N. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat. Neurosci. 10:819-827. PMID: 17589506 [PubMed]

  • Grabe, M., Lai, H.C., Jain, M., Jan, Y.N., and Jan, L.Y. (2007).  Structure prediction for the down state of a potassium channel voltage sensor. Nature 445, 550-553. PMID: 17187053 [PubMed]

  • Gong, Q., Weide, M., Huntsman, C., Xu, Z., Jan, L.Y., Ma D. (2007). Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling.  J. Biol. Chem. 17:13087-13097.  [PubMed] Final Version Available Free

  • Haass, F.A., Jonikas, M., Walter, P., Weissman, J.S., Jan, Y.N., Jan, L.Y., and Schuldiner, M. (2007). Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc. Natl. Acad. Sci. USA 104:18079-18084. PMCID: PMC2084299 [PubMedCentral]

  • Chang, W., Tu, C., Cheng, Z., Rodriguez, L., Chen, T.H., Gassmann, M., Bettler, B., Margeta, M., Jan, L.Y., and Shoback, D. (2007). Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J. Biol. Chem. 282:25030-25040. PMID: 17591780 [PubMed] Final Version Available Free

  • Shaw, R., Fay, A., Puthenveedu, M.A., von Zastrow, M., Jan, Y.N., and Jan, L.Y. (2007). Microtubule plus end tracking proteins target gap junctions directly from the cell interior to adheren junctions. Cell 128:547-560. PMCID: PMC1955433  [PubMedCentral]

 

 

2006

  • Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Genes Dev. 20:2806-2819. PMCID: PMC1619948 [PubMedCentral]

  • Ye, B., and Jan, Y.N. (2006). Visualizing the breaking of symmetry. Dev. Cell 10:411-412. PMID: 16580986  [PubMed]

  • Emoto, K., Parrish, J.Z., Jan, L.Y., and Jan, Y.N. (2006). The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 14:210-213. PMID: 16906135  [PubMed]

  • Kuo, C.T., Zhu, S., Younger, S, Jan, L.Y., and Jan, Y.N. (2006). Identification of e2/e3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron 51:283-290. PMID: 16880123 [PubMed]

  • Sweeney, N.T., Brenman, J.E., Jan, Y.N., and Gao, F.B. (2006). The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. Curr. Biol. 16:1006-1011. PMID: 16713958 [PubMed]

  • Parrish, J.Z., Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 20:820-835. PMCID: PMC1472285  [PubMedCentral]

  • Yu, F., Kuo, C.T., and Jan, Y.N. (2006). Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron 51:13-20. PMID: 16815328 [PubMed]

  • Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., and Jan, Y.N.  (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127:1253-1264. PMCID: PMC1876765 [PubMedCentral]

  • Ja, W.W., Wiser, O., Austin, R.J., Jan, L.Y., and Roberts, R.W., (2006). Turning G proteins on and off using peptide ligands. ACS Chem. Biol. 1:570-574. PMID: 17168552 [PubMed]

  • Raab-Graham, K.F., Haddick, P.C., Jan, Y.N., and Jan, L.Y. (2006). Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314:144-148. PMID: 17023663 [PubMed]  

  • Lai, H.C., and Jan, L.Y. (2006). The distribution and targeting of neuronal voltage-gated ion channels. Nat. Rev. Neurosci. 7:548-562. PMID: 16791144 PMID: 16791144  [PubMed]

  • Chung, H.J., Jan, Y.N., and Jan, L.Y. (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc. Natl. Acad. Sci. USA 103:8870-8875. PMCID: PMC1472242 [PubMedCentral]

  • Grabe, M., Bichet, D., Qian, X., Jan, Y.N., and Jan, L.Y. (2006). K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc. Natl. Acad. Sci. USA 103:14361-14366. PMCID: PMC1570128  [PubMedCentral]

  • Bichet, D., Grabe, M., Jan, Y.N., and Jan, L.Y. (2006). Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc. Natl. Acad. Sci. USA 103:14355-14360. PMCID: PMC1570129 [PubMedCentral]

  • Wiser, O., Qian, X., Ehlers, M., Ja, W.W., Roberts, R.W., Reuveny, E., Jan, Y.N., and Jan, L.Y. (2006). Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron 50:561-573. PMID: 16701207 [PubMed]

  • Gu, C., Zhou, W., Puthenveedu, M.A., Xu, M., Jan, Y.N., and Jan, L.Y. (2006). The Microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting. Neuron 52:803-816. PMID: 17145502  [PubMed]

  • Chung, H.J., and Jan L.Y. (2006). Channeling to the nucleus. Neuron 52:937-940. PMID: 17178398 [PubMed]

  • Fay, A.J., Qian, X., Jan, Y.N., and Jan, L.Y. (2006). SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc. Natl. Acad. Sci. U.S.A. 103:17548-17553. PMCID: PMC1634413 [PubMedCentral]

  • Ye, B., Zhang, Y.W., Jan, L.Y., and Jan, Y.N. (2006). The secretory pathway and neuron polarization. J. Neurosci. 26:10631-10632. PMID: 17050701 [PubMed] Final Version Available Free

 

 

2005

  • Kuo, C.T., Jan, L.Y., and Jan, Y.N. (2005). Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc. Natl. Acad. Sci. USA 102:15230-15235.  [PubMedCentral]

  • Grueber, W.B., Yang, C.H., Ye, B., and Jan, Y.N. (2005). The development of neuronal morphology in insects. Curr Biol. 15:R730-R738.  [PubMed]

  • He, Y., Emoto, K., Fang, X., Ren, N., Tian, X., Jan, Y.N., and Adler, P.N. (2005). Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases. Mol. Biol. Cell. 16:4139-4152.  [PubMed]

  • Goldstein, A.Y.N., Jan, Y.N., and Luo, L. (2005). Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 102:3834-3839.  [PubMedCentral]

  • He, Y., Fang, X., Emoto, K., Jan, Y.N., and Adler, P.N. (2005). The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development. Mol. Biol. Cell 16:689-700.  [PubMedCentral]

  • Ye, B., and Jan, Y.N. (2005). The cadherin superfamily and dendrite development. TRENDS Cell Biol. 15:64-67.  [PubMed]

  • Huang, E.J., Li, H.h., Tang, A.A., Wiggins, A.K., Neve, R.L., Zhong, W., Jan, L.Y., and Jan, Y.N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19:138-151.  [PDF]

  • Kuo, C.T., and Jan, Y.N. (2005). The hand that rocks the spindle. Nat. Cell Biol. 7:858-859.  [PubMed]

  • Roegiers, F., Jan, L.Y., and Jan, Y.N. (2005). Regulation of membrane localization of sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol. Biol. Cell. 16:3480-3487.  [PubMedCentral]

  • Lai, E.C., Roegiers, F., Qin, X., Jan, Y.N., and Rubin, G.M. (2005). The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132:2319-2332.  [PubMed]

  • Anderson, A.C., Kitchens, E.A., Chan, S.W., Hill, C. St., Jan, Y.N., Zhong, W., and Robey, E.A. (2005). The Notch regulator numb links the Notch and TCR signaling pathways. J. Immunol. 174:890-897.  [PubMed]

  • Jan, L.Y., and Siegelbaum, S.A. (2005). Signaling mechanisms. Curr. Opin. Neurobiol. 15:253-256. [PDF]

  • Surti, T.S., Huang, L., Jan, Y.N., Jan, L.Y., and Cooper, E.C. (2005). Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc. Natl. Acad. Sci. USA 102:17828-17833.  [PubMedCentral]  

  • Lai, H.C., Grabe, M., Jan, Y.N., and Jan, L.Y. (2005). The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron 47:395-406. PMID: 16055063.  [PubMed]

  • Ionescu-Zanetti, C., Shaw, R.M., Seo, J., Jan, Y.N., Jan, L.Y., and Lee, L.P. (2005). Mammalian electrophysiology on a microfluidic platform. Proc. Natl. Acad. Sci. U.S.A. 102:9112-9117.  [PubMedCentral]

  • Surti, T.S., and Jan, L.Y. (2005). A potassium channel, the M-channel, as a therapeutic target. Curr. Opin. Investig. Drugs 6:704-711.  [PubMed]

  • Kubo, Y., Adelman, J.P., Clapham, D.E., Jan, L.Y., Karschin, A., Kurachi, Y., Lazdunski, M., Nichols, C.G., Seino, S., and Vandenberg, C.A. (2005). International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol. Rev. 57:509-526.   [PubMed]

  • Cohen, B.E., Pralle, A., Yao, X-J, Swaminath, G., Gandhi, C., Jan, Y.N., Kobilka, B.K., Isacoff, E.Y., and Jan, L.Y. (2005).  A fluorescent probe designed for studying protein conformational change.  Proc. Natl. Acad. Sci. USA 102:965-970.  [PubMedCentral]

  • Huang, C.S., Shi, S.-H., Ule, J., Ruggiu, M., Barker, L.A., Darnell, R.B., Jan, Y.N., and Jan, L.Y. (2005). Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. Cell 123:105-118. PMID: 16213216 [PubMed]

 

 

2004

  • Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr. Biol. 14:2025-2032.  [PubMed]

  • Shi, S.-H., Cox, D.N., Wang, D., Jan, L.Y., and Jan, Y.N. (2004). Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc. Natl. Acad. Sci. USA 101:13341-13345.  [PubMed]

  • Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc. Natl. Acad. Sci. USA 101:13346-13351.  [PubMed]

  • Ye, B., Petritsch, C., Clark, I.E., Gavis, E.R., Jan, L.Y., and Jan, Y.N. (2004). nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Current Biology, 14:314-321.  [PubMed]

  • Moore, A.W., Roegiers, F., Jan, L.Y., and Jan, Y.N. (2004). Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. Genes Dev 18:623-628.  [PubMedCentral]

  • Grueber, W.B., and Jan, Y.N. (2004). Dendritic development: lessons from Drosophila and related branches. Curr. Opin. Neurobiol. 14:74-82.  [PubMed]

  • Roegiers, F., and Jan, Y.N. (2004). Asymmetric cell division. Curr. Opin. Cell Biol. 16:195-205.  [PubMed]

  • McCarroll, S.A., Murphy, C.T., Zou, S., Pletcher, S.D., Chin, C.-S., Jan, Y.N., Kenyon, C., Bargmann, C.I., and Li, H. (2004). Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics 36:197-204.  [PubMed]

  • Grabe, M., Lecar, H., Jan, Y.N., and Jan, L.Y. (2004). A quantitative assessment of models for voltage-dependent gating of ion channels. Proc. Natl. Acad. Sci. USA 101:17640-17645.  [PubMedCentral]

  • Lin, Y.-F., Raab-Graham, K., Jan, Y.N., and Jan, L.Y. (2004). NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101:7799-7804.  [PubMedCentral]

  • Bichet, D., Lin, Y.-F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N., and Jan, L.Y. (2004). Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci USA 101:4441-4446.  [PDF]

  • Emoto, K., He, Y., Ye, B., Grueber, W.B., Adler, P.N., Jan, L.Y., and Jan, Y.N. (2004). Control of dendritic branching and tiling by the Tricornered-kinase/Flurry signaling pathway in Drosophila sensory neurons. Cell 119: 148-149. PMID: 15479641 [PubMed]

 

 

2003

  • Jan, Y.N., and Jan, L.Y. (2003). The control of dendrite development. Neuron 40:229-242.  [PubMed]

  • Rothenberg, M.E., Rogers, S.L., Vale, R.D., Jan, L.Y., and Jan, Y.N. (2003).  Drosophila Pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron 39:779-791.  [PubMed]

  • Grueber, W.B.*, Ye, B.*, Moore, A.W., Jan L.Y., and Jan, Y.N. (2003). Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr. Biol. 13:618-626. (* = equal contribution).  [PubMed]

  • Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2003). Different levels of the homeodomain protein Cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell 112:805-818. PMID: 12654247 [PubMed]

  • Rothenberg, M., and Jan, Y.N. (2003). The hippo hypothesis. Nature 425:469- 470.  [PubMed]

  • Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003)  Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.  Cell 112:63-75. PMID: 12526794 [PubMed]

  • Li, H.-S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40:1105-1118. PMID: 14687546.  [PubMed]

  • Justice, N.J., Roegiers, F.R., Jan, L.Y., and Jan, Y.N. (2003). Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr. Biol. 13:778-783.  [PubMed]

  • Justice, N.J., and Jan, Y.N. (2003). A lethal giant kinase in cell polarity. Nat. Cell Biol. 5:273-274.  [PubMed]

  • Petritsch, C., Tavosanis, G., Turck, C.W., Jan, L.Y., and Jan, Y.N. (2003).  The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.  Dev. Cell 4, 273-281.  [PubMed]

  • Abdelilah-Seyfried, S., Cox, D.N., and Jan, Y.N. (2003).  Bazooka is a permissive factor for the invasive behavior of Discs large tumor cells in Drosophila ovarian follicular epithelia.  Development 130:1927-1935.  [PubMed]

  • Jan, Y.N. (2003). Q & A. Curr. Biol. 13:R378-R379  [PubMed]

  • Gutman, G.A., Chandy, K.G., Adelman, J.P., Aiyar, J., Bayliss, D.A., Clapham, D.E., Covarriubias, M., Desir, G.V., Furuichi, K., Ganetzky, B., Garcia, M.L., Grissmer, S., Jan, L.Y., Karschin, A., Kim, D., Kuperschmidt, S., Kurachi, Y., Lazdunski, M., Lesage, F., Lester, H.A., McKinnon, D., Nichols, C.G., O'Kelly, I., Robbins, J., Robertson, G.A., Rudy, B., Sanguinetti. M,, Seino, S., Stuehmer, W., Tamkun, M.M., Vandenberg, C.A., Wei, A., Wulff, H., and Wymore, R.S. (2003). International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 55:583-586.  [PubMed]

  • Cohen, B., Grabe, M., and Jan, L.Y. (2003). Answers and questions from the KvAP structures. Neuron 39:395-400.  [PubMed]

  • Cooper, E.C., and Jan, L.Y. (2003). M-channels: neurological diseases, neuromodulation, and drug development. Arch. Neurol. 60:496-500.  [PubMed]

  • Bichet, D., Haass, F.A., and Jan, L.Y. (2003). Merging functional studies with structures of inward-rectifier K+ channels. Nature Reviews Neuroscience 4:957-967.  [PubMed]

  • Hu, K., Huang, C.S., Jan, Y.N. and Jan, L.Y. (2003) ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C.  Neuron 38:417-432.  [PubMed]

  • Mitrovic, I., Margeta-Mitrovic, M., Bade, S., Stoffel, M., Jan, L.Y., and Basbaum, A.I. (2003) Contribution of GIRK2-mediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences.  Proc. Natl. Acad. Sci USA 100:271-276.  PMCID: PMC140949 [PubMedCentral]

  • Gu, C., Jan, Y. N., and Jan, L. Y. (2003). A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channel. Science 301:646-649.   PMID: 12893943 [PubMed]

  • Mitrovic, I., Margeta-Mitrovic, M., Bade, S., Stoffel, M., Jan, L.Y., and Basbaum, A.I. (2003). Contribution of GIRK2-mediated postsynaptic signaling to opiate and a2-adrenergic analgesia and analgesic sex differences.  Proc. Natl. Acad. Sci. USA 100:271-276.   [PDF]

  • Pei,L., Wiser, O., Slavin, A., Mu, D., Powers, S., Jan, L.Y., and Hoey, T. (2003). Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function. Proc. Natl. Acad. Sci. USA 100:7803-7807. [PDF]

  • Mu, D., Chen, L., Zhang, X., See, L.-H., Koch, C.M., Yen, C., Tong, J.J., Spiegel, L., Nguyen, K.C.Q., Servoss, A., Peng, Y., Pei, L., Marks, J.R., Lowe, S., Hoey, T., Jan, L.Y., McCombie, W.R., Wigler, M.H., and Powers, S. (2003).  Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.  Cancer Cell 3:297-302.  [PubMed]

  • Hong, Y., Ackerman, L., Jan, L.Y., and Jan, Y.N. (2003). Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture. Proc. Natl. Acad. Sci. USA 100:12712-12717. [PubMed]

  • Sun, Y., Kanekar, S.L., Vetter, M.L., Gorski, S., Jan, Y.N., Glaser, T., and Brown, N.L. (2003). Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evolution & Development 5:532-541. [PubMed]

 

 

2002

  • Moore, A.W., Jan, L.Y., and Jan, Y.N. (2002). hamlet, a binary genetic switch between single and multiple dendrite neuron morphology. Science 297: 1355-1358. PMID: 12193790 [PubMed]

  • Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2002). Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development 129:2867-2878.  [PDF]

  • Rothenberg, M., and Jan, Y. (2002). salvador-The persistence of proliferation. Cancer Cell 2:171-173.   [PubMed]

  • Justice, N.J., and Jan, Y.N. (2002).  Variations on the Notch pathway in neural development  Curr. Opin. Neurobiol., 12: 64-70  [PubMed]

  • Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N., and Zhong, W. (2002).  Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.  Nature 419:929-934.  [PubMed]

  • Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002).  Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.  Development 129:4843-4853.  [PDF]

  • Donovan, J., Kordylewska, A., Jan, Y., and Utset, M. (2002).  Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.  Curr. Biol. 12:1605-1610.  [PubMed]

  • Ma, D., Zerangue, N. Raab-Graham, K., Fried, S.R., Jan, Y.N., and Jan, L.Y. (2002).  Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.  Neuron 33:715-729.  PMID: 11879649[PubMed]

  • Ma, D., and Jan, L.Y. (2002). ER transport signals and trafficking of potassium channels and receptors. Curr. Opin. Neurobiol. 12:287-292.  [PubMed]

  • Cohen, B.E., McAnaney, T.B., Park, E.S., Jan, Y.N., Boxer, S.G., and Jan, L.Y. (2002). Probing protein electrostatics with a synthetic fluorescent amino acid. Science. 296:1700-1703.  [PubMed]

  • Rothenberg, M., and Jan, Y. (2002). salvador-The persistence of proliferation. Cancer Cell 2:171-173. [PDF]

 

 

2001

  • Brenman, J.E., Gao, F-B., Jan, L.Y., and Jan, Y.N. (2001). Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev. Cell 1:667-677.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (2001). Dendrites. Genes Dev. 15:2627-2641.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (2001).  Asymmetric cell division in the Drosophila nervous system.  Nature Revs. Neurosci. 2:772-779.  [PubMed]

  • Hong, Y., Stronach, B., Perrimon, N., Jan, L.Y., and Jan, Y.N. (2001).  Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.  Nature 414:634-638.  [PubMed]

  • Roegiers, F., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (2001).  Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.  Proc. Natl. Acad. Sci USA 98:14469-14474.  [PDF]

  • Sun, T.-Q., Lu, B., Feng, J.-J., Reinhard, C., Jan, Y.N., Frantl, W.J., and Williams, L.T. (2001).  PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signaling.  Nature Cell Biol. 3:628-636.  [PubMed]

  • Lu, B., Roegiers, F., Jan, L.Y., and Jan, Y.N. (2001).  Adherens junctions inhibit asymmetric division in the Drosophila epithelium.  Nature 409:522-525.  [PubMed]

  • Roegiers, F., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (2001).  Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.  Nature Cell Biol. 3:58-67.  [PubMed]

  • Cox, D.N., Abdelilah Seyfried, S., Jan, L.Y., and Jan, Y.N. (2001).  Bazooka and atypical protein kinase C are required to regulate oocyte differenation in the Drosophila ovary.  Proc. Natl. Acad. Sci USA 98:14475-14480.  [PDF]

  • Cox, D.N., Lu, B.-W., Sun, T.-Q., Williams, L.T., and Jan, Y.N. (2001).  Drosophila par-1 is required for oocyte differentiation and microtubule organization.  Curr. Biol. 11:75-87.  [PubMed]

  • Horne-Badovinac, S., Lin, D., Waldron, S., Schwarz, M., Mbamalu, G., Pawson, T., Jan, Y.-N., Stainier, D.Y.R., and Abdelilah-Seyfried, S. (2001).  Positional cloning of heart and soul reveals multiple roles for PKCλ in zebrafish organogenesis.  Curr. Biol. 11:1492-1502.  [PubMed]

  • Ruan, Y., Tecott, L., Jiang, M.-M., Jan, L.Y., and Jan, Y.N. (2001).  Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.  Proc. Natl. Acad. Sci. USA 98: 9907-9912.  [PDF]

  • Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2001).  Function of GB1 and GB2 subunits in G protein coupling of GABAB receptors. Proc. Natl. Acad. Sci USA 98:14649-14654.  [PDF]

  • Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2001).  Ligand-induced signal transduction within heterodimeric GABAB receptor. Proc. Natl. Acad. Sci. USA 98:14643-14648.  [PDF]

  • Yi, B.A., Minor, D.L., Jr., Lin, Y.-F., Jan, Y.N., and Jan, L.Y. (2001).  Controlling potassium channel activities: interplay between the membrane and intracellular factors.  Proc. Natl. Acad. Sci. USA 98:11016-11023.  [PubMed]

  • Cooper, E.C., Harrington, E., Jan, Y.N., and Jan, L.Y. (2001).  M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.  J. Neurosci. 21:9529-9540.  [PDF]

  • Lu, T., Ting, A.Y., Mainland, J., Jan, L.Y., Schultz, P.G., and Yang, J. (2001). Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter. Nat. Neurosci. 4:239-246  [PubMed]

  • Yi, B.A., Lin, Y.F., Jan, Y.N.. and Jan, L.Y. (2001).  Yeast screen for constitutively active mutant G protein-activated potassium channels.  Neuron 29:657-667. PMID: 11301025.  [PubMed]

  • Ma, D., Zerangue, N., Lin, Y.-F., Collins, A., Yu, M., Jan, Y.N., and Jan, L.J.  (2001). Role of ER export signals in controlling surface potassium channel numbers.  Science 291:316-319.  PMID: 11209084 [PubMed]

  • Zerangue, N., Malan, M.J., Fried, S.R., Dazin, P.F., Jan, Y.N., Jan, L.Y., and Schwappach, B. (2001).  Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.  Proc. Natl. Acad. Sci. USA 98: 2431-2436.  [PDF]

 

 

2000

  • Abdelilah-Seyfried, S., Chan, Y.-M., Zeng, C., Justice, N.J., Younger-Shepherd, S., Sharp, L.E., Barbel, S., Meadows, S.A., Jan, L.Y., and Jan, Y.N. (2000). A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155:733-752.  [PDF]

  • Gao, F.-B., Kohwi, M., Brenman, J.E., Jan, L.Y., and Jan, Y.N. (2000). Control of dendritic field formation in Drosophila: The roles of flamingo and competition between homologous neurons. Neuron 28:91-101.  [PubMed]

  • Hassan, B.A., Bermingham, N.A., He, Y., Sun, Y., Jan, Y.N., Zoghbi, H.Y., and Bellen, H.J. (2000) Atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25: 549-561.  [PubMed]

  • Sun, Y., Jan, L.Y., and Jan, Y.N. (2000).  Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.  Proc. Natl. Acad. Sci. 97:6815-6819.  [PDF]

  • Lu, B., Jan, L.Y., and Jan, Y.N. (2000).  Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry.  Annu. Rev. Neurosci. 23:531-556.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (2000).  Polarity in cell division: What frames they fearful asymmetry?  Cell:599-602.  [PubMed]

  • Roegiers, F., and Jan, Y.N. (2000).  Staufen: a common component of mRNA transport in oocytes and neurons?  Trends Cell Biol. 10: 220-224.  [PubMed]

  • Zou, S., Meadows, S., Sharp, L., Jan, L.Y., and Jan, Y.N. (2000).  Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.  Proc. Natl. Acad. Sci. USA 97: 13726-13731.  [PDF]

  • Moore, A.W., Barbel, S., Jan, L.Y., and Jan, Y.N. (2000).  A genomewide survey of basic helix-loop-helix factors in Drosophila.  Proc. Natl. Acad. Sci. USA 97: 10436-10441.  [PDF]

  • Zhong, W., Jiang, M.-M., Schonemann, M.D., Meneses, J.J., Pedersen, R.A., Jan, L.Y., and Jan, Y.N. (2000).  Mouse numb is an essential gene involved in cortical neurogenesis.  Proc. Natl. Acad. Sci. 97:6844-6849.  [PDF]

  • Jan, Y.N. (2000).  Curious Seymour (Book Review).  Cell 101:123-125. [PDF]

  • Jan, Y.N., and Jan, L.Y. (2000).  Humble starts and conserved themes in neurogenetic studies.  Harvey Lecture 94: 21-45.  [PubMed]

  • Jan, L.Y., and Stevens, C.F. (2000). Signalling mechanisms. A decade of signaling. Curr. Opin. Neurobiol. 10:625-630.  [PubMed]

  • Schwappach, B., Zerangue, N., Jan, Y.N. and Jan, L.Y. (2000).  Molecular basis for KATP assembly: Transmembrane interactions mediate association of a K+ channel with an ABC transporter.  Neuron 26: 155-167.  [PubMed]

  • Lin, Y.F., Jan, Y.N. and Jan, L.Y. (2000).  Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.  EMBO J. 19:942-955.  [PubMed]

  • Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2000).  A trafficking checkpoint controls GABAB receptor heterodimerization.  Neuron 27:97-106.  [PubMed]

  • Cooper, E.C., Aldape, K.D., Abosch, A., Barbaro, N.M. Berger, M.S. Peacock, W.S. Jan, Y.N. and Jan, L.Y. (2000).  Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.  Proc. Natl. Acad. Sci. USA 97: 4914-4919.   [PubMed]

  • Zerangue, N., Jan, Y.N., and Jan, L.Y. (2000). An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1. Proc. Natl. Acad. Sci. USA 97:3591-3595. [PubMed]

  • Minor, Jr., D.L., Lin, Y.-F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y., and Berger, J.M. (2000). The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102:657-670. [PubMed]

  • Jan, L.Y., and Jan, Y.N. (2000). Heartfelt Crosstalk: desensitization of the GIRK current. Nat. Cell Biol. 2:E165-E167. [PubMed]

  • Yi, B.A., and Jan, L.Y. (2000). Taking apart the gating of voltage-gated K+ channels. Neuron 27:423-425. [PubMed]

 

 

1999

  • Gao, G.-B., Brenman, J.E., Jan, L.Y., and Jan, Y.N. (1999). Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev. 13:2549-2561.  [PDF]

  • Chan, Y.M., and Jan, Y.N. (1999).  Conservation of neurogenic genes and mechanisms.  Curr. Opin. Neurobiol.5:582-588.  [PubMed]

  • Chan, Y.M., and Jan, Y.N. (1999).  Presenilins, processing of Β-amyloid precursor protein, and notch signaling.  Neuron 23:201-204.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1999).  Asymmetry across species.  Nature Cell Biol. 1:E42-E44.  [PubMed]

  • Lu, B., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1999).  Modes of protein movement that lead to the asymmetric localization of Partner of numb during Drosophila neuroblast division.  Molecul. Cell 4:883-891.  [PubMed]

  • Lu, B., Usui, T., Uemura, T., Jan, L., and Jan, Y.N. (1999).  Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.  Curr. Biol. 9:1247-1250.  [PubMed]

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1999).  Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.  Curr. Biol. 9:155-158.  [PubMed]

  • Margeta-Mitrovic, M., Mitrovic, I., Riley, R.C., Jan, L.Y., and Basbaum, A.I. (1999). Immunohistochemical localization of GABAB receptors in the rat central nervous system. J. Comp. Neurol. 405:299-321.  [PubMed]

  • Cooper, E.C., and Jan, L.Y. (1999). Ion channel genes and human neurological disease: recent progress, prospects, and challenges.  Proc. Natl. Acad. Sci. USA 96:4759-4766.  [PDF][PubMed]

  • Zerangue, N., Schwappach, B., Jan, Y.N., and Jan, L.Y. (1999).  A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane KATP channels.  Neuron 22:537-548.  PMID 10197533 [PubMed]

  • Minor, D.L. Jr., Masseling, S.J., Jan, Y.N., and Jan, L.Y. (1999).  Transmembrane structure of an inwardly rectifying potassium channel.  Cell 96:879-891.  [PubMed]

  • Whistler, J.L., Chuang, H.-H., Chu, P., Jan, L.Y., and von Zastrow, M. (1999).  Functional dissociation of m opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.  Neuron 23:737-746.  [PubMed]

  • Jan, L.Y. (1999). Voltage-dependent K channels. In Potassium Ion Channels: Their Molecular Structure, Function and Diseases, ed. Y. Kurachi, M. Lazdunski and L.Y. Jan. Academic Press, San Diego.

  • Reuveny, E., and Jan, L.Y. (1999). G protein control of G-protein-gated potassium channels. In Potassium Ion Channels: Their Molecular Structure, Function and Diseases, ed. Y. Kurachi, M. Lazdunski and L.Y. Jan.  Academic Press, San Diego.

  • Tinker, A., and Jan, L.Y. (1999). The assembly of inwardly rectifying potassium channels. In Potassium Ion Channels: Their Molecular Structure, Function and Diseases, ed. Y. Kurachi, M. Lazdunski and L.Y. Jan. Academic Press, San Diego.

 

 

1998

  • Chan, Y.M., and Jan, Y.N. (1998).  Roles for proteolysis and trafficking in Notch maturation and signal transduction.  Cell 94:423-426.  [PubMed]

  • Sun, Y., Jan, L.Y., and Jan, Y.N. (1998).  Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.  Development 125:3731-3740.  [PDF]

  • Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.-M., Jan, L.Y., and Jan, Y.N. (1998).  The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.  Proc. Natl. Acad. Sci. USA 95:10637-10642.  [PDF]

  • Lu, B., Rothenberg, M., Jan, L.Y., and Jan, Y.N. (1998).  Partner of Numb, a novel protein that colocalizes with Numb during mitosis, directs Numb asymmetric localization in Drosophila neural and muscle progenitors.  Cell 95:225-235. PMID: 9790529.  [PubMed]

  • Shen, C.-P., Knoblich, J.A., Chan, Y.-M., Jiang, M.-M., Jan, L.Y., and Jan, Y.N. (1998).  Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.  Genes Dev. 12:1837-1846.  [PDF]

  • Zeng C., Younger-Shepherd S., Jan L.Y., and Jan Y.N. (1998).  Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.  Genes Dev. 12:1086-1091.  [PDF]

  • Chien, C.-T., Wang, S., Rothenberg, M., Jan, L.Y., and Jan, Y.N. (1998).  Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.  Mol. Cell. Biol. 18: 598-607.  [PDF]

  • Lu, B., Jan, L.Y., and Jan, Y.N. (1998).  Asymmetric cell division: lessons from flies and worms.  Curr. Opin Genet. Dev. 8:392-399.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1998).  Asymmetric Cell Division.  Nature, 392:775-778.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1998).  Serendipity, the principle of limited sloppiness, and neural development.  Int. J. Dev. Biol. 42:531-533.  [PubMed]

  • Zerangue, N., and Jan, L.Y. (1998). G-protein signaling: fine-tuning signaling kinetics.   Curr. Biol. 8:R313-R316.  [PubMed]

  • Cooper, E.C., Milroy, A., Jan, Y.N., Jan, L.Y., and Lowenstein, D.H. (1998).  Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.  J. Neurosci. 18:955-974.  [PDF]

  • Chuang, H.-h., Yu, M., Jan, Y.N., and Jan, L.Y. (1998).  Evidence that the nucleotide exchange and hydrolysis cycle of G-proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.  Proc. Natl. Acad. Sci. USA 95:11727-11732.  [PDF]

  • Ford, C.E., Skiba, N.P., Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rosal, R., Weng, G., Yang, C.-S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J., and Hamm, H.E. (1998).  Molecular basis for interactions of G protein βγ subunits with effectors.  Science 280:1271-1274.  [PubMed]

  • Stoffel, M., and Jan, L.Y. (1998).  Epilepsy genes: excitement traced to K+ channels.  Nature Genetics 18:6-8.  [PubMed]

 

 

1997

  • Luo, L., Jan, L.Y., and Jan, Y.N. (1997). Rho family small GTP-binding proteins in growth cone signalling. Curr. Opin. Neurobiol. 7:81-86.  [PubMed]

  • Luo, L., Lee, T., Tsai, L., Tang, G., Jan, L.Y., and Jan, Y.N. (1997). Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. Proc. Natl. Acad. Sci. USA 94:12963-12968.  [PDF]

  • Doherty, D., Jan, L.Y., and Jan, Y.N. (1997).  The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.  Development, 124:3881-3893.  [PDF]

  • Lage, P.Z., Jan, Y.N., and Jarman, A.P. (1997).  Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters.  Curr. Biol. 7:166-175.  [PubMed]

  • Anderson, D.J., and Jan, Y.N. (1997).  The Determination of the Neuronal Phenotype.  In Molecular and Cellular Approaches to Neural Development, ed. W.M. Cowan, T.M. Jessell and S.L. Zipursky, pp. 26-63. Oxford University Press, Oxford, United Kingdom.

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1997).  Asymmetric Segregation of the Drosophila Numb Protein during Mitosis: Facts and Speculations.  Cold Spring Harbor Symposia on Quantitative Biology, LXII:71-77.  [PubMed]

  • Wang, S., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1997).  Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.  Development 124:4435-4446.  [PDF]

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1997).  The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.  Proc. Natl. Acad. Sci. USA 94:13005-13010.  [PDF]

  • Shen, C.P., Jan, L.Y., and Jan, Y.N. (1997).  Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila.  Cell 90:449-458. PMID: 9267025.  [PubMed]

  • Clark, I.E., Jan, L.Y., and Jan, Y.N. (1997).  Reciprocal localization of nod and kinesin fusion proteins indicates microtubule polarity in Drosophila oocyte, epithelium, neuron and muscle.  Development 124:461-470.  [PDF]

  • Kanekar, S., Perron, M., Dorsky, R., Harris, W.A., Jan, L.Y., Jan, Y.N., and Vetter, M.L. (1997).  Xath5 participates in a network of bHLH genes in the developing Xenopus retina.  Neuron 19:981-994.  [PubMed]

  • Zhong, W., Jiang, M.M., Weinmaster, G., Jan, L.Y., and Jan, Y.N. (1997).  Differential expression of mammalian Numb, Numblike and Notch1 suggest distinct roles during mouse cortical neurogenesis.  Development 124:1887-1897.  [PDF]

  • Jan, Y.N. (1997).  Pre-empting the arrival of a dark lord (correspondence).  Nature 389:665.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1997).  Receptor-regulated ion channels.  Curr. Opin. Cell Biol. 9:155-160  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1997).  Ways and means for left shifts in the MaxiK channel.  Proc. Natl. Acad. Sci. USA 94:13383-13385.  [PDF]

  • Lüscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C., and Nicoll, R.A. (1997).  G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter action in hippocampal neurons.  Neuron 19:687-695.  [PubMed]

  • Slesinger, P.A., Stoffel, M., Jan, Y.,,N. and Jan, L.Y. (1997).  Defective γ-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.  Proc. Natl. Acad. Sci. USA 94:12210-12217.  [PDF]

  • Chuang, H.H., Jan, Y.N., and Jan, L.Y. (1997).  Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium.  Cell 89:1121-1132.  PMID: 9215634 [PubMed]

  • Collins, A. Chuang, H.H., Jan, Y.N., and Jan, L.Y. (1997). Scanning mutagenesis of the putative transmembrane segments of Kir2.1, an inward rectifier potassium channel.  Proc. Natl. Acad. Sci. USA 94:5456-5460.  [PDF]

  • Huang, C.L., Jan, Y.,N., and Jan, L.Y. (1997).  Binding of the G protein βγ subunit to multiple regions of G protein-gated inward rectifying K+ channels.  FEBS Lett. 405:291-298.  [PubMed]

  • Yang, J., Yu, M., Jan, Y.N., and Jan, L.Y. (1997).  Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.  Proc. Natl. Acad. Sci. USA 94:1568-1572.  [PDF]

  • Signorini, S., Liao, Y.J., Duncan, S.A., Jan, L.Y., and Stoffel, M. (1997).  Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.  Proc. Natl. Acad. Sci. USA 94:923-927.  [PDF]

  • Vivaudou, M., Chan, K.W., Sui, J.L., Jan, L.Y., Reuveny, E., and D.E. Logothetis (1997).  Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.  J. Biol. Chem. 272:31553-31560.  [PDF]

  • Jan, L.Y., and Jan, Y.N. (1997).  Voltage-gated and inwardly rectifying potassium channels. J. Physiol. 505:267-282.  [PDF]

  • Jan, L.Y., and Jan, Y.N. (1997).  Cloned potassium channels from eukaryotes and prokaryotes.  Annu. Rev. Neurosci. 20:91-123.  [PubMed]

  • Jan,L.Y. (1997). Ion Channels-Molecules in Action (book review). Cell 89:829-830.   [PDF]

  • Lumsden, A. and Jan, Y.N. (1997).  Editorial overview:  The end of the beginning Curr. Opin. Neurobiol. 7:3-6. [PDF]

 

 

1996

  • Kolodziej, P.A. Timpe, L.C., Mitchell, K.J., Fried, S.R., Goodman, C.S., Jan, L.Y., and Jan, Y.N. (1996). frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87:197-204.  [PubMed]

  • Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1996). Differential effects of the Rac GTPase on purkinje cell axons, dendrites and dendritic spines. Nature 379:837-840. PMID: 8587609.  [PubMed]

  • Lane, M.E., Sauer, K., Wallace, K., Jan, Y.N., Lehner, C.F., and Vaessin, H. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87:1225-1235.  [PubMed]

  • Chien, C.T., Hsiao, C.D., Jan, L.Y., and Jan, Y.N. (1996).  Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.  Proc. Natl. Acad. Sci. USA 93:13239-13244.  [PDF]

  • Doherty, D., Feger, G., Younger-Shephard, S., Jan, L.Y., and Jan, Y.N. (1996).  Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, In Drosophila wing formation.  Genes Dev. 10:421-434.  [PubMed]

  • Frise, E., Knoblich, J.A., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1996).  The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.  Proc. Natl. Acad. Sci. USA 93:11925-11932.  [PDF]

  • Kraut, R., Chia, W., Jan, L.Y., Jan, Y.N., and Knoblich, J.A. (1996).  Role of inscuteable in orienting asymmetric cell divisions in Drosophila.  Nature 383:50-55. PMID: 8779714.  [PubMed]

  • Guo, M., Jan, L.Y., and Jan, Y.N. (1996).  Control of daughter cell fates during asymmetric division; interaction of Numb and Notch.  Neuron 17:27-41. PMID: 8755476.  [PubMed]

  • Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. and Jan, Y.N. (1996).  Asymmetric localization of a mammalian Numb homologue during mouse cortical neurogenesis.  Neuron 17:43-53.  [PubMed]

  • Fakler, B., Schultz, J.H., Yang, J., Schulte, U., Brändle, U., Zenner, H.P., Jan, L.Y., and Ruppersberg, J.P. (1996).  Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.  EMBO J. 15:4093-4099.  [PubMed]

  • Liao, Y.J., Jan, Y.N., and Jan, L.Y. (1996).  Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brains.  J. Neurosci. 16:7137-7150.  [PDF]

  • Tinker, A., Jan, Y.N., and Jan, L.Y. (1996).  Regions responsible for the assembly of inwardly rectifying potassium channels.  Cell 87:857-868.   PMID: 8945513 [PubMed]

  • Slesinger, P.A., Patil, N. Liao Y.J., Jan, Y.N., Jan, L.Y., and Cox, D.R. (1996).  Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.  Neuron 16: 321-331.  [PubMed]

  • Reuveny, E. Jan, Y.N., and Jan, L.Y. (1996).  Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K+-selective permeation.  Biophys. J. 70: 754-761  [PubMed]

  • Collins, A., German, M.S., Jan, Y.N., Jan, L.Y., and Zhao, B. (1996).  A strongly inwardly rectifying K+ channel that is sensitive to ATP.  J.Neurosci. 16:1-9.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1996). Membrane permeability–Editorial overview. Curr. Opin. Cell Biol. 8:449-451. [PDF]

  • Luo, L., Jan, L.Y., and Jan, Y.N. (1996). Small GTPases in axon outgrowth. Perspect. Dev. Neurobiol. 4:199-204.

 

 

1995

  • Eaton, S., Auvien, P., Luo, L., Jan, Y.N., and Simons, K. (1995). CDC42 and Rac1 control different actin dependent processes in the Drosophila wing disc epithelium. J. Cell. Biol. 131:151-164.  [PDF]

  • Kolodziej, P., Jan, L.Y., and Jan, Y.N. (1995). Mutations that affect the length, fasciculation and ventral orientation of specific axons in the Drosophila embryo. Neuron 15:273-286.  [PubMed]

  • Feger, G., Vaessin, H., Su, T.T., Wolff, E., Jan, L.Y., and Jan, Y.N. (1995). dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila. EMBO J. 14:5387-5398.  [PubMed]

  • Jarman, A.P., Sun, Y., Jan, L.Y., and Jan, Y.N. (1995).  Role of the proneural gene, atonal in formation of Drosophila chordotonal organs and photoreceptors.  Development 121:2019-2030.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (1995).  Maggot's hair and bug's eye: role of cell interactions and intrinsic factors in cell fate specification.  Neuron 14:1-5.  [PubMed]

  • Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1995).  Asymmetric segregation of Numb and Prospero during cell division.  Nature 377:624-627. PMID: 7566172.  [PubMed]

  • Guo, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1995).  tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.  Neuron 14:913-925.  [PubMed]

  • Xu, J., Yu, W., Jan, Y.N., Jan, L.Y., and Li, M. (1995).  Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.  J. Biol. Chem. 270:24761-24768.  [PDF]

  • Klumpp, D.J., Song, E.J., Ito, S., Sheng, M.H., Jan, L.Y., and Pinto, L.H. (1995).   The Shaker-like potassium channels of the mouse rod bipolar call and their contributions to the membrane current.  J. Neurosci. 15:5004-5013.  [PDF]

  • Yang, J., Jan, Y.N., and Jan, L.Y. (1995).  Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.  Neuron 15:1441-1447.  PMID: 8845166 [PubMed]

  • Slesinger, P.A., Reuveny, E., Jan, Y.N., and Jan, L.Y. (1995).  Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.  Neuron 15:1145-1156.  [PubMed]

  • Huang, C-L., Slesinger, P.A., Casey, P.J., Jan, Y.N., and Jan, L.Y. (1995).  Evidence that direct binding of Gßγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.  Neuron 15:1133-1143.  [PubMed]

  • Yang, J., Jan, Y.N., and Jan, L.Y. (1995).  Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.  Neuron 14:1047-1054.  [PubMed]

  • Sheng, M., Jan, Y.N., and Jan, L.Y. (1995). The molecular organization of voltage-dependent K+ channel in vivo. Progress in Brain Research 105:87-93.

  • Kim, E., Niethammer, M., Rothschild, A., Jan, Y.N. and Sheng, M. (1995).  Clustering of Shaker type K+channels by direct interaction with the PSD-95/SAP90 family of membrane-associated guanylate kinases.  Nature 378:85-88.[PDF]

 

 

1994

  • Luo, L., Liao, Y.J., Jan, L.Y., and Jan, Y.N. (1994). Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8:1787-1802.  [PubMed]

  • Vaessin, H., Brand, M., Jan, L.Y., and Jan, Y.N. (1994).  daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.  Development 120:935-945.  [PDF]

  • Jarman, A.P., Grell, E.H., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1994).  atonal is the proneural gene for Drosophila photoreceptors.  Nature 369:398-400. PMID: 8196767.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1994).  Genetic control of cell fate specification in Drosophila peripheral nervous system.  Annu. Rev. of Genet. 28:373-393.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1994).  Neuronal cell fate specification in Drosophila.  Curr. Opin. Neurobiol. 4:8-13.  [PubMed]

  • Rhyu, M.S., Jan, L.Y., and Jan, Y.N. (1994).  Asymmetric distribution of numb protein during division of the Sensory Organ Precursor cell confers distinct fates to daughter cells.  Cell 76:477-491. PMID: 8324823.  [PubMed]

  • Jongens, T.A., Ackerman, L.D., Swedlow, J.R., Jan, L.Y., and Jan, Y.N. (1994).  Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.  Genes Dev. 8:2123-2136.  [PubMed]

  • Clark, I., Giniger, E., Ruohola-Baker, H., Jan, L.Y., and Jan, Y.N. (1994).  Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.  Curr. Biol. 4:289-300.  [PubMed]

  • Ruohola-Baker, H., Jan, L.Y., and Jan, Y.N. (1994).  The role of gene cassettes in axis formation during Drosophila oogenesis.  Trends Genet. 10:89-94.  [PubMed]

  • Feder, J.N., Li, L., Jan, L.Y., and Jan, Y.N. (1994).  Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene hairy.  Genomics 20:56-61.  [PubMed]

  • Liu, H., Wang, H., Sheng, M., Jan, Y.N., Jan, L.Y., and Basbaum, A.I. (1994).  Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.  Proc. Natl. Acad. Sci. USA 91:8383-8387.  [PDF]

  • Sheng, M., Cummings, J., Roldan, L.A., Jan, Y.N., and Jan, L.Y. (1994).  Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.  Nature 368: 144-147.  [PubMed]

  • Sheng, M., Tsaur, M-L, Jan, Y.N., and Jan, L.Y. (1994). Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.  J. Neurosci. 14:2408-2417.  [PDF]

  • Lopez, G., Jan, Y.N., and Jan, L.Y. (1994).  Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.  Nature 367: 179-182.  [PubMed]

  • Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iñiguez-Lluhi, J.A., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N., and Jan, L.Y. (1994).  Activation of the cloned muscarinic potassium channel by G protein βγ subunits.  Nature 370:143-146.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1994).  Potassium channels and their evolving gates.  Nature 371:119-122.  [PubMed]

  • Li, M., Unwin, N., Stauffer, K.A., Jan, Y.N., and Jan, L.Y. (1994). Images of purified Shaker potassium channels. Curr. Biol. 4:110-115. [PDF]

  • Giniger, E., Tietje, K., Jan, L.Y., and Jan, Y.N. (1994). Iola encodes a putative transcription factor required for axon growth and guidance in Drosophila. Development 120:1385-1398. [PDF]

  • Jan, L.Y., and Jan, Y.N. (1994). Editorial overview–Membrane permeability. Curr. Opin. Cell Biol. 6:569-570. [PDF]

 

 

1993

  • Giniger, E., Wells, W.A.E., Jan, L.Y., and Jan, Y.N. (1993). Tracing neurons with a Kinesin-ß-Galactosidase fusion protein. Roux's Arch. Dev. Biol. 202:112-122.  [PDF]

  • Giniger, E., Jan, L.Y., and Jan, Y.N. (1993). Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development 117:431-440.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (1993). Peripheral Nervous System. In The Development of Drosophila melanogaster, ed. M. Bate and A. Martinez-Arias, Chapter 20, pp. 1207-1244. Cold Spring Harbor Press, Cold Spring Harbor, New York.  

  • Jan, Y.N., and Jan, L.Y. (1993).  HLH protein, fly neurogenesis and vertebrate myogenesis.  Cell 75:827-830.  [PubMed]

  • Ghysen, A., Dambly-Chaudière, C., Jan, L.Y., and Jan, Y.N. (1993).  Cell interaction and gene interaction in peripheral neurogenesis.  Genes Dev. 7:723-733.  [PubMed]

  • Jarman, A.P., Grau, Y., Jan, L.Y., and Jan, Y.N. (1993).  atonal is a proneural gene for chordotonal organs in the Drosophila peripheral nervous system.  Cell 73:1307-1321. PMID: 8324823.  [PubMed]

  • Jarman, A.P., Brand, M., Jan, L.Y., and Jan, Y.N. (1993).  The regulation and function of helix-loop-helix gene, asense, in Drosophila neural precursors.  Development 119:19-29.  [PDF]

  • Brand, M., Jarman, A.P., Jan, L.Y., and Jan, Y.N. (1993).  asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.  Development 119:1-17.  [PDF]

  • Bodmer, R., Jan, L.Y., and Jan, Y.N. (1993).  A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.  Roux's Arch. Dev. Biol. 202:371-381.

  • Blochlinger, K., Jan, L.Y., and Jan, Y.N. (1993).  Post-embryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila.  Development 117:441-450.  [PDF]

  • Siegel, V., Jongens, T.A., Jan, L.Y., and Jan, Y.N. (1993).  pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.  Development 119:1187-1202.  [PDF]

  • Theurkauf, W.E., Alberts, B.M., Jan, Y.N., and Jongens, T.A. (1993).  A central role for microtubules in the differentiation of Drosophila oocytes.  Development 118:1169-1180.  [PDF]

  • Ruohola-Baker, H., Grell, E., Chou, T.B., Baker, D., Jan, L.Y., and Jan, Y.N. (1993).  Spatially localized Rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis.  Cell 73:953-965.  [PubMed]

  • Feder, J.N., Jan, L.Y., and Jan, Y.N. (1993).  A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.  Mol. Cell Biol. 13:105-113.  [PDF]

  • Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993).  The S4-S5 loop contributes to the ion selective pore of potassium channels.  Neuron 11:739-749.  [PubMed]

  • Sheng, M., Liao, J., Jan, Y.N., and Jan, L.Y. (1993). Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.  Nature 365:72-75.  PMID: 8361540 [PubMed]

  • Kubo, Y., Reuveny, E., Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993).  Primary structure and functional expression of a rat G protein coupled muscarinic potassium channel.  Nature 364:802-806.  PMID: 8355805[PubMed]

  • Kubo, Y., Baldwin, T.J., Jan, Y.N., and Jan, L.Y. (1993).  Primary structure and functional expression of a mouse inward rectifier potassium channel.  Nature 362:127-133.  PMID: 7680768[PubMed]

  • Crowley, T.E., Hoey, T., Liu, J.K., Jan, Y.N., Jan, L.Y., and Tjian, R. (1993). A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Nature 361:557-561. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1993). Functional gene cassettes in development. Proc. Natl. Acad. Sci. USA. 90:8305-8307. [PDF]

  • Li, M., Isacoff, E., Jan, Y.N., and Jan, L.Y. (1993). Assembly of potassium channels. In Molecular basis of ion channels and receptors involved in nerve excitation, synaptic transmission and muscle contraction. Ann. N.Y. Acad. Sci. 707:51-59. [PDF]

  • Boulianne, G.L., de la Concha, A., Campos-Ortega, J.A., Jan, L.Y., and Jan, Y.N. (1993) The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO 12: 2586. [PDF]

 

 

1992

  • Bellen, H., Vaessin, H., Bier, E., Kolodkin, A., D'Evelyn, D., Kooyer, S., and Jan, Y.N. (1992). The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics 131:365-375.  [PDF]

  • Hartenstein, V., and Jan, Y.N. (1992). Studying Drosophila Embryogenesis with P-lacZ Enhancer Trap Lines. Roux's Arch. Dev. Biol. 201:194-220.

  • Bier, E., Vaessin, H., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1992).  deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.  Genes Dev. 6:2137-2151.  [PubMed]

  • Rao, Y., Bodmer, R., Jan, L.Y., and Jan Y.N. (1992).  The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.  Development 116:31-40.  [PDF]

  • Younger-Shepherd, S., Vaessin, H., Bier, E., Jan, L.Y., and Jan, Y.N. (1992).  deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination.  Cell 70:911-922.  [PubMed]

  • Rutledge, B. J., Zhang, K., Bier, E., Jan, Y.N., and Perrimon, N. (1992).  The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.  Genes Dev. 6:1503-1517.  [PubMed]

  • Jan, Y. N., and Jan, L.Y. (1992).  Neuronal specification.  Curr. Opin. Genet. Dev. 2:608-613.  [PubMed]

  • Jongens, T.A., Hay, B., Jan, L.Y., and Jan, Y.N. (1992).  The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila.  Cell 70:569-584.  [PubMed]

  • Li, M., Jan, Y.N., and Jan, L.Y. (1992). Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker K+ channel.  Science 257:1225-1230.  PMID: 1519059 [PubMed]

  • Sheng, M., Tsaur, M-L, Jan, Y.N., and Jan, L.Y. (1992).  Subcellular segregation of two A-type K+ channel proteins in rat central neurons.  Neuron 9:271-284.  [PubMed]

  • Tsaur, M.L.,Sheng, M., Lowenstein, D.H., Jan, Y.N., and Jan, L.Y. (1992).  Differential expression of K+ channel mRNAs in the rat brain and down regulation in the hippocampus following seizures.  Neuron 8:1055-1067.  [PubMed]

  • Jan, L.Y., and Y.N. Jan. (1992).  Structural elements involved in specific K+ channel functions.  Annu. Rev. Physiol. 54:537-555.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1992).  Tracing the roots of ion channels.  Cell 69:715-718.  [PubMed]

  • Baldwin, T.J., Isacoff, E., Li, M., Lopez, G.A., Sheng, M., Tsaur, M.L., Jan, Y.N. and Jan, L.Y. (1992). Elucidation of biophysical and biological properties of voltage-gated potassium channels. Cold Spring Harbor Symposium  vol: LVII, pp.491-499.

 

 

1991

  • Boulianne, G.L, de la Concha, A., Campos-Ortega, J.A., Jan, L.Y., and Jan, Y.N. (1991).  The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons.  EMBO J. 10:2975-2983.  [PubMed]

  • Rao, Y., Jan, L.Y., and Jan, Y.N. (1991).  Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.  Genes Dev. 5:1577-1588.  [PubMed]

  • Blochlinger, K., Jan, L.Y., and Jan, Y.N. (1991).  Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.  Genes Dev. 5:1124-1135.  [PubMed]

  • Campos-Ortega, J., and Jan, Y.N. (1991).  Genetic and molecular bases of neurogenesis in Drosophila melanogaster.  Annu. Rev. Neurosci. 14:399-420  [PubMed]

  • Vaessin, H., Grell, E., Wolff, E., Bier, E., Jan, L.Y., and Jan, Y.N. (1991).  prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila.  Cell 67: 941-953. PMID: 1720353.  [PubMed]

  • Ruohola, H., Bremer, K.A., Baker, D., Swedlowe, J.R., Jan, L.Y., and Jan, Y.N. (1991).  Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila.  Cell 66:433-449.  [PubMed]

  • Isacoff, E.Y., Jan, Y.N., and Jan, L.Y. (1991).  Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel.  Nature 353:86-90.  [PubMed]

  • Lopez, G.A., Jan, Y.N., and Jan, L.Y. (1991).  Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels.  Neuron 7:327-336.  [PubMed]

  • Baldwin, T.B., Tsaur, M-L, Lopez, G.A., Jan, Y.N., and Jan, L.Y. (1991).  Characterization of a mammalian K+ channel cDNA for an inactivating voltage-sensitive K+ channel.  Neuron 7:471-483.  [PubMed]

  • Papazian, D.M., Timpe, L.C., Jan, Y.N., and Jan, L.Y. (1991).  Alteration of voltage-dependence of Shaker K+ channel by mutations in the S4 sequence.  Nature 349:305-310.  [PubMed]

  • Timpe, L.C., Isacoff, E., Kimmerly, W., Papazian, D., Jan, Y.N., and Jan, L.Y. (1991).  Molecular studies of voltage-sensitive potassium channels. Fidia Research Foundation Symposium Series, vol. 7, pp.193-202.

 

 

1990

  • Jan, Y.N., and Jan, L.Y. (1990).  Genes required for specifying cell fates in Drosophila embryonic sensory nervous system.  Trends Neurosci. 13:493-498.  [PubMed]

  • Vaessin, H., Caudy, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1990).  The role of helix-loop-helix proteins in Drosophila neurogenesis.  Cold Spring Harbor Symposia on Quantitative Biology LV: 239-245.  [PubMed]

  • Bodmer, R., Jan, L.Y., and Jan, Y.N. (1990).  A new homeobox-containing gene, msh-2, is transiently expressed early during mesodcerm formation of Drosophila.  Development 110:661-670.  [PubMed]

  • Blochlinger, K., Bodmer, R., Jan, L.Y., and Jan, Y.N. (1990).  Patterns of expression of Cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.  Genes Dev. 4:1322-1331.  [PubMed]

  • Rao,Y., Jan, L.Y., and Jan, Y.N. (1990).  Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.  Nature 345:163-167.  [PubMed]

  • Bier, E., Jan, L.Y., and Jan, Y.N. (1990).  rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.  Genes Dev. 4:190-203.  [PubMed]

  • Hay, B., Jan, L.Y., and Jan, Y.N. (1990). Localization of vasa, a component of Drosophila polar granules, in maternal effect mutants that alter embryonic anteroposterior polarity.  Development 109:425-433.  [PubMed]

  • Klaiber, K., Williams, N., Roberts, T.M., Papazian, D.M., Jan, L.Y., and Miller, C. (1990).  Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.  Neuron 5:211-216.  [PubMed]

  • Isacoff, E., Jan, Y.N., and Jan, L.Y. (1990).  Evidence for the formation of heteromulteric potassium channels in Xenopus oocytes.  Nature 345: 530-534.  PMID: 2112229 [PubMed]

  • Schwarz, T.L., Papazian, D.M., Carretto, R.C., Jan, Y.N., and Jan, L.Y. (1990).   Immunological characterization of K+-channel components from the Shaker locus and the differential distribution of splicing variants in Drosophila.  Neuron 4:119-127.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1990).  How might the diversity of potassium channels be generated?  Trends Neurosci. 13:413-419.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1990).  A superfamily of ion channels.  Nature 345:672.  [PubMed]

  • Isacoff, E., Papazian, D., Timpe, L., Jan, Y.N., and Jan, L.Y. (1990). Molecular studies of voltage-gated potassium channels. Cold Spring Harbor Symposia on Quantitative Biol., vol. LV, pp. 9-17. [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1990).  In Rememberance of Stephen W. Kuffler, ed. U.J. McMahan, pp. 47-50. Sinauer Inc., Sunderland, MA.

 

 

1989

  • Bier, E., Vaessin, H., Shepherd, S., Lee, K., McCall, K., Barbel, S., Ackerman, L., Carretto, R., Uemura, T., Grell, E., Jan, L.Y., and Jan, Y.N. (1989). Searching for Pattern and Mutation in the Drosophila Genome with a P-lacZ Vector. Genes Dev. 3:1273-1287.[PDF]

  • Bodmer, R., Carretto, R., and Jan, Y.N. (1989).  Neurogenesis of the Peripheral Nervous System in Drosophila Embryos: DNA replication Patterns and Cell lineages.  Neuron 3:21-32.  [PubMed]

  • Uemura, T., Shepherd, S., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1989).  numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryo.  Cell 58:349-360. PMID: 2752427.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1989). Voltage-sensitive ion channels. Cell 56:13-25.  [PubMed]

  • Leung, H.T., Branton, W.D., Phillips, H.S., Jan, L.Y., and Byerly, L. (1989). Spider Toxins selectively block calcium currents in Drosophila. Neuron 3:767-772. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1989). Genes involved in early neural development of Drosophila. In: The Assembly of the Nervous System. 47th Symposium of Soc. of Dev. Biology pp. 1-16. Alan R. Liss, Inc., New York.

  • Schwarz, T., Carretto, R., Papazian, D., Tempe, B., Timpe, L., Jan, Y.N., and Jan, L.Y. (1989). A family of potasium channels from the Shaker locus in Drosophila. In Molecular Biology of Neuroreceptors and Ion Channels (Maelicke, A., Ed.). New York: Springer-Verlag, pp. 215-229.

  • Murre, C., Schonleber McCaw, P., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., Weintraub, H. and Baltimore, D. (1989).  Interactions between heterologous  helix-loop-helix proteins bind specifically to a common DNA sequence.  Cell 58:537-544. [PDF]

     

 

 

1988

  • Katz, F., Moats, W., and Jan, Y.N. (1988). A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). EMBO J. 7:3471-3477  [PubMed]

  • Bier, E., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1988). Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science 240: 913-916.  [PubMed]

  • Jan, Y.N., and Jan, L.Y. (1989).  Genes involved in early neural development of Drosophila.  In The Assembly of the Nervous System. 47th Symposium of Soc. of Dev. Biology, pp. 1-16. Alan R. Liss, Inc., New York.

  • Murre, C., Schonleber McCaw, P., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., Weintraub, H., and Baltimore, D. (1989).  Heterodimers of helix-loop-helix proteins bind specifically to a common DNA sequence.  Cell 58:537-544.  [PubMed]

  • Caudy, M., Vaessin, H., Brand, M., Tuma, R., Jan, L.Y., and Jan, Y.N. (1988).  daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.  Cell 55:1061-1067. PMID: 3203380.  [PubMed]

  • Dambly-Chaudiere, C., Ghysen, A., Jan, L.Y., and Jan, Y.N. (1988).  The determination of sense organs in Drosophila: interaction of scute with daughterless.  Roux's Arch. Dev. Biol. 197:419-423.[PDF]

  • Caudy, M., Grell, E., Dambly-Chaudiere, C., Ghysen, A., Jan, L.Y., and Jan, Y.N. (1988).  The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.  Genes Dev. 2:843-852.  [PubMed]

  • Blochlinger, K.B., Bodmer, R., Jack, J., Jan, L.Y., and Jan, Y.N. (1988).  Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila.  Nature 333:629-635.  [PubMed]

  • Hay, B., Jan, L.Y., and Jan, Y.N. (1988).  A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.  Cell 55:577-587.  [PubMed]

  • Hay, B., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1988).  Identification of a component of Drosophila polar granules.  Development 103: 625-640.  [PubMed]

  • Timpe, L.C., Jan, Y.N., and Jan, L.Y. (1988).  Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.   Neuron 1:659-667.  [PubMed]

  • Tempel, B.L, Jan, Y.N., and Jan, L.Y. (1988).  Cloning of a probable potassium channel from mouse brain.  Nature 332:837-839.  [PubMed]

  • Timpe, L.C., Schwarz, T.L., Tempel, B.L, Papazian, D.M., Jan, Y.N., and Jan, L.Y. (1988).   Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.  Nature 331:143-145.  [PubMed]

  • Schwarz, T.L., Tempel, B.L, Papazian, D.M., Jan, Y.N., and Jan, L.Y. (1988).  Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.  Nature 331:137-142. PMID: 2448635.  [PubMed]

  • Papazian, D.M., Schwarz, T.L., Tempel, B.L., Timpe, L.C., and Jan, L.Y. (1988). Ion channels in Drosophila. Annu. Rev. Physiol. 50:379-394. [PDF]

  • Jan, L.Y., Papazian, D.M., Schwarz, T.L., Tempel, B.L., Timpe, L.C., and Jan, Y.N. (1988). Molecular Studies of Voltage-Sensitive Potassium Channels.  Proceedings of the First NIMH Conference of Molecular Neurobiology, vol. 1, pp. 27-32.

  • Jan, Y.N., and Jan, L.Y. (1988). Mutations Affecting Neurogenesis and Neuronal Identity in Drosophila Melanogaster. Proceedings of the First NIMH Conference on Molecular Neurobiology, vol. 1 pp.229-233.

 

 

1987

  • Bodmer, R., and Jan, Y.N. (1987). Morphological differentiation of the embryonic peripheral neurons in Drosophila. Roux's Arch. Dev. Biol. 196:69-77.  [PDF]

  • Jan, Y.N., Bodmer, R., Jan, L.Y., Ghysen, A., and Dambly-Chaudière, C. (1987). Mutations affecting the embryonic development of the peripheral nervous system in Drosophila. In Molecular Entomology, ed. Liss, Alan R., 49:45-56. New York.

  • Bodmer, R., Jan Barbel, S., Shepherd, S., Jack, J.W., Jan, L.Y., and Jan, Y.N. (1987).  Transformation of sensory organs by mutations of the cut locus of Drosophila melanogaster.  Cell 51: 293-307.  [PubMed]

  • Timpe, L.C., and Jan, L.Y. (1987).  Gene dosage and complementation analysis of the Shaker locus in Drosophila.  J. Neurosci. 7:1307-1317.  [PDF]

  • Tempel, B.L., Papazian, D.M., Schwarz, T.L., Jan, Y.N., and Jan, L.Y. (1987).  Sequence of a probable K+ channel component in Drosophila deduced from Shaker cDNA.  Science 237:770-775.  [PubMed]

  • Papazian, D.M., Schwarz, T.L., Tempel, B.L., Jan, Y.N., and Jan, L.Y. (1987).  Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.  Science 237:749-753.  PMID: 2441470 [PubMed]

  • Royden, C.S., Pirrotta, V., and Jan, L.Y. (1987). The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12. Cell 51:165-173. [PDF]

  • Bowers, C.W., Phillips, H.S., Lee, P., Jan, Y.N., and Jan, L.Y. (1987). Identification and purification of an irreversible presynaptic neurotoxin from the venom of the spider Hololena curta. Proc. Natl. Acad. Sci. USA 84:3506-3510. [PDF]

  • Branton, D., Kolton, L., Jan, Y.N., and Jan, L.Y. (1987). Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila. J. Neurosci. 7:4195-4200. [PDF]

  • Branton, D., Phillips, H. and Jan, Y.N. (1987).  The LHRH family of peptide messengers in the frog nervous system.  Progress in Brain Research 68:205‑215.

 

 

1980-1986

  • Ghysen, A., Dambly-Chaudiere, C., Aceves, E., Jan, L.Y., and Jan, Y.N. (1986). Sensory neurons and peripheral pathways in Drosophila embryos. Roux's Arch. Dev. Biol. 195:281-289.[PDF]

  • Bowers, C., Jan, L.Y., and Jan, Y.N. (1986).  A substance P-like peptide in bullfrog autonomic nerve terminals-Anatomy, biochemistry and physiology.  Neuroscience 19:343-356.  [PubMed]

  • Dambly-Chaudiere, C., Ghysen, A., Jan, Y.N., and Jan, L.Y. (1986). Muscle connections between imaginal discs in Drosophila. Dev. Biol. 113:288-294.[PDF]

  • Ghysen, A., Jan, L.Y., and Jan, Y.N. (1985). Segmental determination in Drosophila central nervous system. Cell 40:943-948.  [PubMed]

  • Jan, Y.N., Ghysen, A., Christoph, I., Barbel, S., and Jan, L.Y. (1985). Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster. J. Neurosci. 5:2453-2464.  [PubMed]

  • Jan, L.Y., Papazian, D., Timpe, L., O'Farrell, P., and Jan, Y.N. (1985). Application of Drosophila molecular genetics in the study of neural function-studies of the Shaker locus for a potassium channel.  Trends Neurosci. 8:2334-238. [PDF]

  • Jan, L.Y., Barbel, S., Timpe, L., Laffer, C., Salkoff, L., O'Farrell, P., and Jan, Y.N. (1985).  Studies of Shaker mutations affecting a K+ channel in Drosophila. Current Topics in Membrane and Transport 23:67-77.

  • Jan, Y.N., and Jan, L.Y. (1983). LHRH-like peptide–A neurotransmitter capable of “action at a distance” in autonomic ganglia.  Trends Neurosci. 6:320-325. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1983). Some features of peptidergic transmission. Progress in Brain Research, 58:49-59.

  • Jan, Y.N., and Jan, L.Y. (1983). Electrophysiological studies of peptide actions: Techniques used and novel features of peptidergic transmission. In: Brain Peptides, eds. Krieger, D.T., Brownstein, M., Martin, J.B., pp. 547-563, John Wiley and Sons, New York.

  • Jan, Y.N., and Jan, L.Y. (1983). Coexistence and co-release of cholinergic and peptidergic transmitters in preganglionic C fibers of bullfrog sympathetic ganglia. Fed. Proc. 42:2929-2933.

  • Jan, L.Y., Barbel, S., Timpe, L., Laffer, C., Salkoff, L., O'Farrell, P., and Jan, Y.N. (1983). Mutating a gene for a potassium channel by hybrid dysgenesis. An approach to the cloning of the Shaker locus in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology 48:233-245.

  • Jan, Y.N., Bowers, C., Branton, D., Evans, L., and Jan, L.Y. (1983). Roles of peptides in neuronal function–Studies using frog autonomic ganglia.  Cold Spring Harbor Symposia on Quantitative Biology 48:363-374.

  • Ghysen, A., Dambly-Chaudiere, C., Jan, L.Y., and Jan, Y.N. (1982). Segmental differences in the protein content of Drosophila imaginal discs. EMBO J. 1:1373-1379. [PDF]

  • Jan, L.Y., and Jan, Y.N. (1982) Antibodies to horseradish peroxidase as a neuronal marker in Drosophila and in grasshopper embryos. Proc. Natl. Acad. Sci. USA 79:2700-2704.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1982).  Peptidergic transmission in sympathetic ganglia of the frog.   J. Physiol. 327:219-246.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1982). Genetic and immunologic studies of the synapse in Drosophila.  In Ciba Foundation Symposium: Neuropharmacology of Insects, pp. 221-239.

  • Jan, Y.N., and Jan, L.Y. (1982). LHRH-like peptide as a transmitter in sympathetic ganglia. In: Frontiers in Neuroendocrinology, Vol. 7, eds., Ganong, W.F. and Martini, L., pp. 211-230, Raven Press.

  • Jan, L.Y., and Jan, Y.N. (1981). Mutations of the synapse in Drosophila. In Development in the Nervous System eds. D.R. Garrod and J.D. Feldman, Cambridge. pp. 347-359. Cambridge University Press.

  • Jan, L.Y., and Jan Y.N. (1981). Role of an LHRH-like peptide as a neurotr

  • ansmitter in sympathetic ganglia of the frog. Fed. Proc. 40:2560-2564.

  • Jan, L.Y., Jan, Y.N., and Brownfield, M.S. (1980).  Peptidergic transmitters in synaptic boutons of sympathetic ganglia.  Nature 288:380-382.[PubMed]

  • Jan, Y.N., Jan, L.Y., and Kuffler, S.W. (1980).  Further evidence for peptidergic transmission in sympathetic ganglia.  Proc. Natl. Acad. Sci. USA 77:5008-5012.  [PDF]

  • Jan, Y.N., and Jan, L.Y. (1980). Genetic Dissection of Synaptic transmission in Drosophila Melanogaster.  In Insect Neurobiology and Pesticide Action, ed. F.E. Rickett, pp. 161-168, London:  The Society of Chemical Industry.

 

 

1974-1979

  • Jan, Y.N., Jan, L.Y., and Kuffler, S.W. (1979).  A peptide as a possible transmitter in sympathetic ganglia of the frog.  Proc. Natl. Acad. Sci. USA 76:1501-1505.  [PDF]

  • Heuser, J.E., Reese, T.S., Dennis, M.J., Jan, Y.N., Jan, L.Y., and Evans, L. (1979).   Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.  J. Cell Biol. 81:275-300. [PDF]

  • Jan, Y.N., and Jan, L.Y. (1978).  Genetic dissection of short-term and long-term facilitation in Drosophila.  Proc. Natl. Acad. Sci. USA 75:515-519.  [PDF]

  • Wu, C.F., Ganetzky, B., Jan, L.Y., Jan, Y.N., and Benzer, S. (1978). A Drosophila mutant with a temperature-sensitive block in nerve conduction. Proc. Natl. Acad. Sci. USA 75:4047-4051. [PDF]

  • Jan, Y.N., Jan, L.Y., and Dennis, M.J. (1977).  Two mutations of synaptic transmission in Drosophila.  Proc. Roy. Soc. Lond. B 198:87-108.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1976).  L-glutamate as an excitatory transmitter at Drosophila larval neuromuscular junction.  J. Physiol. 262:215-236.  [PubMed]

  • Jan, L.Y., and Jan, Y.N. (1976).  Properties of the larval neuromuscular junction in Drosophila melanogaster.  J. Physiol. 262:189-214.  [PubMed]

  • Dudai, Y., Jan, Y.N., Byers, D., Quinn, W.G. and Benzer, S. (1976).  dunce a mutant of Drosophila deficient in learning.  Proc. Natl. Acad. Sci. USA 73:1684‑1688. [PDF]

  • Jan, L.Y., and Revel, J.P. (1975). Hemocyanin-antibody labeling of rhodopsin in mouse retina for a scanning electron microscope study. J. Supramol. Structure 3:61-66.

  • Jan, L.Y. (1975). The isomeric configuration of the bacteriorhodopsin chromophore. Vision Res. 15:1081-1086.

  • Cohen, R.J., Jan, Y.N., Matricon, J. and Delbrück, M. (1975).  Avoidance response, house response, and wind responses of the sporangiophore of Phycomyces.  J. Gen. Physiol. 66:67‑95. [PDF]

  • Jan, L.Y., and Revel, J.P. (1974). Ultrastructural localization of rhodopsin in the vertebrate retina. J. Cell Biol. 62:257-273. [PDF]

  • Jan, Y.N. (1974).  Properties and cellular location of chitin synthetase in Phycomyces blakesleeanus.  J. Biol. Chem. 249:1973‑1979. [PDF]

 

 
   
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