Home     Function Group     Development Group     All Jan Publications     People     Contact  
 
     


 Home
 Function Group
         Research
         Publications
 Development Group
         Research
         Publications
 All Jan Publications
 Current Personnel
 Former Personnel
 Jan Lab Reunion/  Symposium
 Microarray Data
 Contact Us



 


S E L E C T    P U B L I C A T I O N S   (by topic)

Drosophila nervous system
Dendrite development, neuronal morphogenesis and neuronal circuitry
Cell fate specification, mostly neuronal
Asymmetric division and neural stem cell development
Oogenesis and pole cell development
Genomics
Vertebrate homologs
Miscellaneous
Reminiscence

Drosophila Nervous System

  1. Abdelilah-Seyfried, S., Chan, Y.-M., Zeng, C., Justice, N.J., Younger-Shepherd, S., Sharp, L.E., Barbel, S., Meadows, S.A., Jan, L.Y., and Jan, Y.N. (2000). A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organ. Genetics 155:733-752.  [PDF]

  2. Lane, M.E., Sauer, K., Wallace, K., Jan, Y.N., Lehner, C.F., and Vaessin, H. (1996). Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87:1225-1235.  [PubMed]

  3. Feger, G., Vaessin, H., Su, T.T., Wolff, E., Jan, L.Y., and Jan, Y.N. (1995). dpa, a member of the MCM family, is required for mitotic DNA replication but not endoreplication in Drosophila. EMBO J. 14:5387-5398.  [PubMed]

  4. Giniger, E., Jan, L.Y., and Jan, Y.N. (1993). Specifying the path of the intersegmental nerve of the Drosophila embryo: a role for Delta and Notch. Development 117:431-440.  [PDF]

  5. Jan, Y.N., and Jan, L.Y. (1993). Peripheral Nervous System. In The Development of Drosophila melanogaster, ed. M. Bate and A. Martinez-Arias, Chapter 20, pp. 1207-1244. Cold Spring Harbor Press, Cold Spring Harbor, New York.  

  6. Bellen, H., Vaessin, H., Bier, E., Kolodkin, A., D'Evelyn, D., Kooyer, S., and Jan, Y.N. (1992). The Drosophila couch potato gene: an essential gene required for normal adult behavior. Genetics 131:365-375.  [PDF]

  7. Hartenstein, V., and Jan, Y.N. (1992). Studying Drosophila Embryogenesis with P-lacZ Enhancer Trap Lines. Roux's Arch. Dev. Biol. 201:194-220.  

  8. Bier, E., Vaessin, H., Shepherd, S., Lee, K., McCall, K., Barbel, S., Ackerman, L., Carretto, R., Uemura, T., Grell, E., Jan, L.Y., and Jan, Y.N. (1989). Searching for Pattern and Mutation in the Drosophila Genome with a P-lacZ Vector. Genes Dev. 3:1273-1287.  

  9. Katz, F., Moats, W., and Jan, Y.N. (1988). A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). EMBO J. 7:3471-3477  [PubMed]

  10. Bier, E., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1988). Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science 240: 913-916.  [PubMed]

  11. Jan, Y.N., Bodmer, R., Jan, L.Y., Ghysen, A., and Dambly-Chaudière, C. (1987). Mutations affecting the embryonic development of the peripheral nervous system in Drosophila. In Molecular Entomology, ed. Liss, Alan R., 49:45-56. New York.  

  12. Ghysen, A., Dambly-Chaudiere, C., Aceves, E., Jan, L.Y., and Jan, Y.N. (1986). Sensory neurons and peripheral pathways in Drosophila embryos. Roux's Arch. Dev. Biol. 195:281-289.  

  13. Ghysen, A., Jan, L.Y., and Jan, Y.N. (1985). Segmental determination in Drosophila central nervous system. Cell 40:943-948.  [PubMed]

  14. Jan, Y.N., Ghysen, A., Christoph, I., Barbel, S., and Jan, L.Y. (1985). Formation of neuronal pathways in the imaginal discs of Drosophila melanogaster. J. Neurosci. 5:2453-2464.  [PubMed]

  15. Ghysen, A., Dambly-Chaudiere, C., Jan, L.Y., and Jan, Y.N. (1982). Segmental differences in the protein content of Drosophila imaginal discs. EMBO J. 1:1373-1379.  

  16. Jan, L.Y., and Jan, Y.N. (1982) Antibodies to horseradish peroxidase as a neuronal marker in Drosophila and in grasshopper embryos. Proc. Natl. Acad. Sci. USA 79:2700-2704.  [PubMed]

Dendrite Development, Neuronal Morphogenesis, and Neuronal Circuit Assembly

  1. Rumpf, S., Bagley, J.A., Thompson-Peer, K.L., Zhu, S., Gorczyca, D., Beckstead, R.B., Jan, L.Y., and Jan, Y.N. (2014). Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism. Proc Natl Acad Sci USA. May 5. [Epub ahead of print]. PMCID: PMC4034197. [PubMedCentral]

  2. Han, C., Song, Y., Wang, D., Franc, N.C., Jan, L.Y., and Jan, Y.N. (2014) Epidermal Cells are the Primary Phagocytes in the Fragmentation and Clearance of Degenerating Dendrites in Drosophila. Neuron 81:544-60. PMCID: PMC3995171. [PDF]

  3. Yuan, Q., Song Y., Yang, C.H, Jan, L.Y., and Jan, Y.N. (2014). Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila, Nature Neurosci. 17:81-8. PMCID: PMC3995170. [PubMedCentral]

  4. Kim, W.J., Jan, L.Y., and Jan, Y.N. (2013). A PDF/NPF Neuropeptide Signaling Circuitry of Male Drosophila melanogaster Controls Rival-Induced Prolonged Mating. Neuron 80:1190-205. PMCID: PMC3867312. [PubMedCentral]

  5. Zhang, W., Yan, Z., Jan, L.Y., and Jan, Y.N. (2013) Sound response mediated by the TRP channels NOMPC, NANCHUNG, and INACTIVE in chordotonal organs of Drosophila larvae. PNAS USA 110:13612-7. PMCID: PMC3746866. [PubMedCentral]

  6. Yan, Z., Zhang, W., He, Y., Gorczyca, D., Xiang, Y., Cheng, L.E., Meltzer, S., Jan, L.Y., and Jan, Y.N. (2013) Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature 493:221-5. PMCID: PMC3917554. [PubMedCentral]

  7. Ori-McKenney, K.M., Jan, L.Y., and Jan, YN. (2012) Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron 76:921-30. PMCID: PMC3523279. [PubMedCentral]

  8. Kim, W.J., Jan, L.Y., and Jan, Y.N. (2012) Contribution of Visual and Circadian Neural circuits to Memory for Prolonged Mating induced by Rivals. Nature Neurosci. 15:876–883. PMCID: PMC3417086. [PubMedCentral]

  9. Song, Y., Ori-McKenney, K.M., Zheng, Y., Han, C., Jan, L.Y., and Jan, Y.N. (2012). Regeneration of Drosophila sensory neuron axons and dendrites is regulated by the Akt pathway involving Pten and microRNA bantam. Genes Dev. 26:1612-1625. PMCID: PMC3404388. [PDF]

  10. Ultanir, S.K., Hertz, N.T., Li, G., Ge, W.P., Burlingame, A.L., Pleasure, S.J., Shokat, K.M., Jan, L.Y., and Jan, Y.N. (2012) Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development. Neuron 73:1127-1142. PMCID: PMC3333840. [PDF]

  11. Han, C., Wang, D., Soba, P., Zhu, S., Lin, X., Jan, L.Y., and Jan, Y.N. (2012) Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. Neuron 73:64-78. PMCID: PMC3269260. [PubMedCentral]

  12. Lee, S.B., Bagley, J.A., Lee, H.Y., Jan, L.Y., and Jan, Y.N. (2011) Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila. Proc Natl Acad Sci USA 108:16795-16800. PMCID: PMC3189048. [PDF]

  13. Yuan, Q., Xiang, Y., Yan, Z., Han, C., Jan, L.Y., and Jan, Y.N. (2011) Light-induced structural and functional plasticity in Drosophila larval visual system. Science 333:1458-62. PMID: 21903815. [PDF]

  14. Han, C., Jan, L.Y., and Jan, Y.N. (2011) Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila. Proc Natl Acad Sci U S A. 108:9673-8. PMCID: PMC3111288. [PubMedCentral]

  15. Ye, B., Kim, J.H., Yang, L.M., McLachlan, I., Younger, S., Jan, L.Y. and Jan, Y.N. (2011) Differential regulation of dendritic and axonal development by the novel Kruppel-like factor Dar1. J. Neurosci. 31:3309-3319. PMCID: PMC3086283. [PDF]

  16. Rumpf, S., Lee, S.B., Jan, L.Y. and Jan, Y.N. (2011) Neuronal remodeling and apoptosis require VCP-dependent degradation of the apoptosis inhibitor DIAP1. Development 138:1153-1160. PMCID: PMC3042870. [PDF]

  17. Xiang, Y., Yuan, Q., Vogt, N., Looger, L.L., Jan, L.Y., and Jan, Y.N. (2010) Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature 468:921-926. PMCID: PMC3026603. [PDF]

  18. Cheng, L.E., Song, W., Looger, L.L., Jan, L.Y., and Jan, Y.N. (2010) The Role of the TRP Channel NompC in Drosophila Larval and Adult Locomotion. Neuron. 67:373-380. PMCID: PMC2933178. [PDF]

  19. Jan, Y.N., and Jan, L.Y. (2010) Branching out: mechanisms of dendritic arborization. Nat. Rev. Neurosci. 11:316-328. PMCID: PMC3079328. [PDF]

  20. Parrish, J.Z., Xu, P., Kim, K.C., Jan, L.Y., and Jan, Y.N. (2009) The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in Drosophila sensory neurons. Neuron 63:788-802.  PMCID: PMC2772869. [PubMed]

  21. Kim, M.D., Wen, Y., Jan, Y.N. (2009) Patterning and organization of motor neuron dendrites in the Drosophila larva. Dev Biol. 336:213-21. PMCID: PMC2785125. [PubMedCentral]

  22. Lee, H.H., Jan, L.Y., and Jan, Y.N. (2009) Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci, USA. 106:6363-8.  PMCID: PMC2661847. [PubMed]

  23. Yang, C.H., Rumpf, S., Xiang, Y., Gordon, M.D., Song, W., Jan, L.Y., and Jan, Y.N. (2009) Control of the postmating behavioral switch in Drosophila females by internal sensory neurons. Neuron. 61:519-26.  PMCID: PMC2748846. [PubMed]

  24. Zheng, Y., Wildonger, J., Ye, B., Zhang, Y., Kita, A., Younger, S.H., Zimmerman, S., Jan, L.Y., Jan, Y.N. (2008) Dynein is required for polarized dendritic transport and uniform microtubule orientations in axons. Nat Cell Biol. 10: 1172-80.  PMCID: PMC2588425. [PubMedCentral]

  25. Sokol, S.N., Xu, P., Jan, Y.N., and Ambros, V. (2008). Dropsophila let-7 micro RNA is required for remodeling of the neuromusculature during metamorphosis. Genes & Dev. 22:1591-159.  PMCID: PMC2428057. [PubMedCentral]

  26. Wildonger, J., Jan, L.Y., Jan, Y.N. (2008) The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Genes Dev. 22: 2447-2453. PMCID: PMC2749676 [PubMed]

  27. Yang, C.H., Belawat, P., Hafen, E., Jan, L>Y>, and Jan, Y.N. (2008). Drosophila Egg-Layng site selectin as a system to study simple decision-making processes. Science 319:1679-16. PMCID: PMC2581776. [PubMedCentral]

  28. Ye, B., Zhang, Y., Song, W., Younger, S.H., Jan, L.Y., and Jan, Y.N. (2007). Growing dendrites and axons differ in their reliance on the secretory pathway. Cell 130:717-729.  [PubMed]

  29. Soba, P., Zhu, S., Emoto, K., Younger, S., Yang, S.J., Yu, H.H., Lee, T., Jan, L.Y., and Jan, Y.N. (2007). Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron 54:403-416.  [PubMed]

  30. Parrish, J.Z., Emoto, K., Kim, M.D., and Jan, Y.N. (2007). Mechanisms that regulate establishment, maintenance, and remodeling of dendritic fields. Annu. Rev. Neurosci. 30:399-423.  [PubMed]

  31. Parrish, J.Z., Emoto, K., Jan, L.Y., and Jan, Y.N. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21:956-972.  [PubMed]

  32. Song, W., Onishi, M., Jan, L.Y., and Jan, Y.N. (2007). Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae. Proc Natl Acad Sci U S A. 104:5199-5204.  [PDF]

  33. Grueber, W.B., Ye, B., Yang, C.H., Younger, S., Borden, K., Jan, L.Y., and Jan, Y.N. (2007). Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology. Development 134:55-64.  [PubMed]

  34. Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). The bHLH-PAS protein Spineless is necessary for the diversification of dendrite morphology of Drosophila dendritic arborization neurons. Genes Dev. 20:2806-2819.  [PubMed]

  35. Ye, B., and Jan, Y.N. (2006). Visualizing the breaking of symmetry. Dev. Cell 10:411-412.  [PubMed]

  36. Emoto, K., Parrish, J.Z., Jan, L.Y., and Jan, Y.N. (2006). The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature 14:210-213.   [PubMed]

  37. Kuo, C.T., Zhu, S., Younger, S, Jan, L.Y., and Jan, Y.N. (2006). Identification of e2/e3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron 51:283-290.  [PubMed]

  38. Sweeney, N.T., Brenman, J.E., Jan, Y.N., and Gao, F.B. (2006). The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. Curr. Biol. 16:1006-1011.  [PubMed]

  39. Parrish, J.Z., Kim, M.D., Jan, L.Y., and Jan, Y.N. (2006). Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites. Genes Dev. 20:820-835.   [PubMed]

  40. Kuo, C.T., Jan, L.Y., and Jan, Y.N. (2005). Dendrite-specific remodeling of Drosophila sensory neurons requires matrix metalloproteases, ubiquitin-proteasome, and ecdysone signaling. Proc. Natl. Acad. Sci. USA 102:15230-15235.  [PubMed]

  41. Grueber, W.B., Yang, C.H., Ye, B., and Jan, Y.N. (2005). The development of neuronal morphology in insects. Curr Biol. 15:R730-R738.  [PubMed]

  42. He, Y., Emoto, K., Fang, X., Ren, N., Tian, X., Jan, Y.N., and Adler, P.N. (2005). Drosophila Mob Family Proteins Interact with the Related Tricornered (Trc) and Warts (Wts) Kinases. Mol. Biol. Cell. 16:4139-4152.  [PubMed]

  43. Goldstein, A.Y.N., Jan, Y.N., and Luo, L. (2005). Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc. Natl. Acad. Sci. USA 102:3834-3839.  [PubMed]

  44. He, Y., Fang, X., Emoto, K., Jan, Y.N., and Adler, P.N. (2005). The tricornered Ser/Thr protein kinase is regulated by phosphorylation and interacts with furry during Drosophila wing hair development. Mol. Biol. Cell 16:689-700.  [PubMed]

  45. Ye, B., and Jan, Y.N. (2005). The cadherin superfamily and dendrite development. TRENDS Cell Biol. 15:64-67.  [PubMed]

  46. Huang, E.J., Li, H.h., Tang, A.A., Wiggins, A.K., Neve, R.L., Zhong, W., Jan, L.Y., and Jan, Y.N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19:138-151.  [PubMed]

  47. Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr. Biol. 14:2025-2032.  [PubMed]

  48. Shi, S.-H., Cox, D.N., Wang, D., Jan, L.Y., and Jan, Y.N. (2004). Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc. Natl. Acad. Sci. USA 101:13341-13345.  [PDF]

  49. Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc. Natl. Acad. Sci. USA 101:13346-13351.  [PDF]

  50. Emoto, K., He, Y., Ye, B., Grueber, W.B., Adler, P.N., Jan, L.Y., and Jan, Y.N. (2004). Control of dendritic branching and tiling by the Tricornered-kinase/Furry signaling pathway in Drosophila sensory neurons. Cell 119:245-256. PMID: 15479641 [PubMed]

  51. Ye, B., Petritsch, C., Clark, I.E., Gavis, E.R., Jan, L.Y., and Jan, Y.N. (2004). nanos and pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Current Biology, 14:314-321.  [PubMed]

  52. Grueber, W.B., and Jan, Y.N. (2004). Dendritic development: lessons from Drosophila and related branches. Curr. Opin. Neurobiol. 14:74-82.  [PubMed]

  53. Jan, Y.N., and Jan, L.Y. (2003). The control of dendrite development. Neuron 40:229-242.  [PubMed]

  54. Rothenberg, M.E., Rogers, S.L., Vale, R.D., Jan, L.Y., and Jan, Y.N. (2003).  Drosophila Pod-1 crosslinks both actin and microtubules and controls the targeting of axons. Neuron 39:779-791.  [PubMed]

  55. Grueber, W.B.*, Ye, B.*, Moore, A.W., Jan L.Y., and Jan, Y.N. (2003). Dendrites of distinct classes of Drosophila sensory neurons show different capacities for homotypic repulsion. Curr. Biol. 13:618-626. (* = equal contribution).  [PubMed]

  56. Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2003). Different levels of the homeodomain protein Cut regulate distinct dendrite branching patterns of Drosophila multidendritic neurons. Cell 112:805-818. PMID: 12526794 [PubMed]

  57. Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003)  Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.  Cell 112:63-75.  [PubMed]

  58. Moore, A.W., Jan, L.Y., and Jan, Y.N. (2002). hamlet, a binary genetic switch between single and multiple dendrite neuron morphology. Science 297: 1355-1358.  PMID: 12193790 [PubMed]

  59. Grueber, W.B., Jan, L.Y., and Jan, Y.N. (2002). Tiling of the Drosophila epidermis by multidendritic sensory neurons. Development 129:2867-2878.  [PDF]

  60. Brenman, J.E., Gao, F-B., Jan, L.Y., and Jan, Y.N. (2001). Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev. Cell 1:667-677.  [PubMed]

  61. Jan, Y.N., and Jan, L.Y. (2001). Dendrites. Genes Dev. 15:2627-2641.  [PDF]

  62. Gao, F.-B., Kohwi, M., Brenman, J.E., Jan, L.Y., and Jan, Y.N. (2000). Control of dendritic field formation in Drosophila: The roles of flamingo and competition between homologous neurons. Neuron 28:91-101.  [PubMed]

  63. Hassan, B.A., Bermingham, N.A., He, Y., Sun, Y., Jan, Y.N., Zoghbi, H.Y., and Bellen, H.J. (2000) Atonal regulates neurite arborization but does not act as a proneural gene in the Drosophila brain. Neuron 25: 549-561.  [PubMed]

  64. Gao, G.-B., Brenman, J.E., Jan, L.Y., and Jan, Y.N. (1999). Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Genes Dev. 13:2549-2561.  [PDF]

  65. Luo, L., Jan, L.Y., and Jan, Y.N. (1997). Rho family small GTP-binding proteins in growth cone signalling. Curr. Opin. Neurobiol. 7:81-86.  [PubMed]

  66. Luo, L., Lee, T., Tsai, L., Tang, G., Jan, L.Y., and Jan, Y.N. (1997). Genghis Khan (Gek) as a putative effector for Drosophila Cdc42 and regulator of actin polymerization. Proc. Natl. Acad. Sci. USA 94:12963-12968.  [PDF]

  67. Kolodziej, P.A. Timpe, L.C., Mitchell, K.J., Fried, S.R., Goodman, C.S., Jan, L.Y., and Jan, Y.N. (1996). frazzled encodes a Drosophila member of the DCC immunoglobulin subfamily and is required for CNS and motor axon guidance. Cell 87:197-204.  [PubMed]

  68. Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1996). Differential effects of the Rac GTPase on purkinje cell axons, dendrites and dendritic spines. Nature 379:837-840. PMID: 8587609.  [PubMed]

  69. Eaton, S., Auvien, P., Luo, L., Jan, Y.N., and Simons, K. (1995). CDC42 and Rac1 control different actin dependent processes in the Drosophila wing disc epithelium. J. Cell. Biol. 131:151-164.  [PDF]

  70. Kolodziej, P., Jan, L.Y., and Jan, Y.N. (1995). Mutations that affect the length, fasciculation and ventral orientation of specific axons in the Drosophila embryo. Neuron 15:273-286.  [PubMed]

  71. Luo, L., Liao, Y.J., Jan, L.Y., and Jan, Y.N. (1994). Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8:1787-1802.  [PubMed]

  72. Giniger, E., Wells, W.A.E., Jan, L.Y., and Jan, Y.N. (1993). Tracing neurons with a Kinesin-ß-Galactosidase fusion protein. Roux's Arch. Dev. Biol. 202:112-122.  

  73. Bodmer, R., and Jan, Y.N. (1987). Morphological differentiation of the embryonic peripheral neurons in Drosophila. Roux's Arch. Dev. Biol. 196:69-77.  

Cell fate specification, mostly neuronal

  1. Moore, A.W., Roegiers, F., Jan, L.Y., and Jan, Y.N. (2004). Conversion of neurons and glia to external-cell fates in the external sensory organs of Drosophila hamlet mutants by a cousin-cousin cell-type respecification. Genes Dev 18:623-628.  [PubMed]

  2. Rothenberg, M., and Jan, Y.N. (2003). The hippo hypothesis. Nature 425:469- 470.  [PubMed]

  3. Rothenberg, M., and Jan, Y. (2002). salvador-The persistence of proliferation. Cancer Cell 2:171-173.   [PubMed]

  4. Justice, N.J., and Jan, Y.N. (2002).  Variations on the Notch pathway in neural development  Curr. Opin. Neurobiol., 12: 64-70  [PubMed]

  5. Sun, Y., Jan, L.Y., and Jan, Y.N. (2000).  Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.  Proc. Natl. Acad. Sci. 97:6815-6819.  [PDF]

  6. Chan, Y.M., and Jan, Y.N. (1999).  Conservation of neurogenic genes and mechanisms.  Curr. Opin. Neurobiol.5:582-588.  [PubMed]

  7. Chan, Y.M., and Jan, Y.N. (1999).  Presenilins, processing of Β-amyloid precursor protein, and notch signaling.  Neuron 23:201-204.  [PubMed]

  8. Chan, Y.M., and Jan, Y.N. (1998).  Roles for proteolysis and trafficking in Notch maturation and signal transduction.  Cell 94:423-426.  [PubMed]

  9. Sun, Y., Jan, L.Y., and Jan, Y.N. (1998).  Transcriptional regulation of atonal during development of the Drosophila peripheral nervous system.  Development 125:3731-3740.  [PDF]

  10. Zeng, C., Justice, N.J., Abdelilah, S., Chan, Y.-M., Jan, L.Y., and Jan, Y.N. (1998).  The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development.  Proc. Natl. Acad. Sci. USA 95:10637-10642.  [PDF]

  11. Doherty, D., Jan, L.Y., and Jan, Y.N. (1997).  The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.  Development, 124:3881-3893.  [PDF]

  12. Lage, P.Z., Jan, Y.N., and Jarman, A.P. (1997).  Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters.  Curr. Biol. 7:166-175.  [PubMed]

  13. Anderson, D.J., and Jan, Y.N. (1997).  The Determination of the Neuronal Phenotype.  In Molecular and Cellular Approaches to Neural Development, ed. W.M. Cowan, T.M. Jessell and S.L. Zipursky, pp. 26-63. Oxford University Press, Oxford, United Kingdom.  

  14. Chien, C.T., Hsiao, C.D., Jan, L.Y., and Jan, Y.N. (1996).  Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes.  Proc. Natl. Acad. Sci. USA 93:13239-13244.  [PDF]

  15. Doherty, D., Feger, G., Younger-Shephard, S., Jan, L.Y., and Jan, Y.N. (1996).  Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, In Drosophila wing formation.  Genes Dev. 10:421-434.  [PubMed]

  16. Jarman, A.P., Sun, Y., Jan, L.Y., and Jan, Y.N. (1995).  Role of the proneural gene, atonal in formation of Drosophila chordotonal organs and photoreceptors.  Development 121:2019-2030.  [PDF]

  17. Vaessin, H., Brand, M., Jan, L.Y., and Jan, Y.N. (1994).  daughterless is essential for neuronal precursor differentiation but not for initiation of neuronal precursor formation in Drosophila embryo.  Development 120:935-945.  [PDF]

  18. Jarman, A.P., Grell, E.H., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1994).  atonal is the proneural gene for Drosophila photoreceptors.  Nature 369:398-400. PMID: 8196767.  [PubMed]

  19. Jan, Y.N., and Jan, L.Y. (1994).  Genetic control of cell fate specification in Drosophila peripheral nervous system.  Annu. Rev. of Genet. 28:373-393.  [PubMed]

  20. Jan, Y.N., and Jan, L.Y. (1994).  Neuronal cell fate specification in Drosophila.  Curr. Opin. Neurobiol. 4:8-13.  [PubMed]

  21. Jan, Y.N., and Jan, L.Y. (1993).  HLH protein, fly neurogenesis and vertebrate myogenesis.  Cell 75:827-830.  [PubMed]

  22. Ghysen, A., Dambly-Chaudière, C., Jan, L.Y., and Jan, Y.N. (1993).  Cell interaction and gene interaction in peripheral neurogenesis.  Genes Dev. 7:723-733.  [PubMed]

  23. Jarman, A.P., Grau, Y., Jan, L.Y., and Jan, Y.N. (1993).  atonal is a proneural gene for chordotonal organs in the Drosophila peripheral nervous system.  Cell 73:1307-1321. PMID: 8324823.  [PubMed]

  24. Jarman, A.P., Brand, M., Jan, L.Y., and Jan, Y.N. (1993).  The regulation and function of helix-loop-helix gene, asense, in Drosophila neural precursors.  Development 119:19-29.  [PDF]

  25. Brand, M., Jarman, A.P., Jan, L.Y., and Jan, Y.N. (1993).  asense is a Drosophila neural precursor gene and is capable of initiating sense organ formation.  Development 119:1-17.  [PDF]

  26. Bodmer, R., Jan, L.Y., and Jan, Y.N. (1993).  A late role for a subset of neurogenic genes to limit sensory precursor recruitments in Drosophila embryos.  Roux's Arch. Dev. Biol. 202:371-381.  

  27. Blochlinger, K., Jan, L.Y., and Jan, Y.N. (1993).  Post-embryonic patterns of expression of cut, a locus regulating sensory organ identity in Drosophila.  Development 117:441-450.  [PDF]

  28. Bier, E., Vaessin, H., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1992).  deadpan, an essential pan-neural gene in Drosophila, encodes a helix-loop-helix protein similar to the hairy gene product.  Genes Dev. 6:2137-2151.  [PubMed]

  29. Rao, Y., Bodmer, R., Jan, L.Y., and Jan Y.N. (1992).  The big brain gene of Drosophila functions to control the number of neuronal precursors in the peripheral nervous system.  Development 116:31-40.  [PDF]

  30. Younger-Shepherd, S., Vaessin, H., Bier, E., Jan, L.Y., and Jan, Y.N. (1992).  deadpan, an essential pan-neural gene encoding an HLH protein, acts as a denominator in Drosophila sex determination.  Cell 70:911-922.  [PubMed]

  31. Rutledge, B. J., Zhang, K., Bier, E., Jan, Y.N., and Perrimon, N. (1992).  The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.  Genes Dev. 6:1503-1517.  [PubMed]

  32. Jan, Y. N., and Jan, L.Y. (1992).  Neuronal specification.  Curr. Opin. Genet. Dev. 2:608-613.  [PubMed]

  33. Boulianne, G.L, de la Concha, A., Campos-Ortega, J.A., Jan, L.Y., and Jan, Y.N. (1991).  The Drosophila neurogenic gene neuralized encodes a protein with a novel putative DNA-binding motif.  EMBO J. 10:2975-2983.  [PubMed]

  34. Rao, Y., Jan, L.Y., and Jan, Y.N. (1991).  Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.  Genes Dev. 5:1577-1588.  [PubMed]

  35. Blochlinger, K., Jan, L.Y., and Jan, Y.N. (1991).  Transformation of sensory organ identity by ectopic expression of Cut in Drosophila.  Genes Dev. 5:1124-1135.  [PubMed]

  36. Campos-Ortega, J., and Jan, Y.N. (1991).  Genetic and molecular bases of neurogenesis in Drosophila melanogaster.  Annu. Rev. Neurosci. 14:399-420  [PubMed]

  37. Jan, Y.N., and Jan, L.Y. (1990).  Genes required for specifying cell fates in Drosophila embryonic sensory nervous system.  Trends Neurosci. 13:493-498.  [PubMed]

  38. Vaessin, H., Caudy, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1990).  The role of helix-loop-helix proteins in Drosophila neurogenesis.  Cold Spring Harbor Symposia on Quantitative Biology LV: 239-245.  [PubMed]

  39. Bodmer, R., Jan, L.Y., and Jan, Y.N. (1990).  A new homeobox-containing gene, msh-2, is transiently expressed early during mesodcerm formation of Drosophila.  Development 110:661-670.  [PubMed]

  40. Blochlinger, K., Bodmer, R., Jan, L.Y., and Jan, Y.N. (1990).  Patterns of expression of Cut, a protein required for external sensory organ development in wild-type and cut mutant Drosophila embryos.  Genes Dev. 4:1322-1331.  [PubMed]

  41. Rao,Y., Jan, L.Y., and Jan, Y.N. (1990).  Similarity of the product of the Drosophila neurogenic gene big brain to transmembrane channel proteins.  Nature 345:163-167.  [PubMed]

  42. Bier, E., Jan, L.Y., and Jan, Y.N. (1990).  rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.  Genes Dev. 4:190-203.  [PubMed]

  43. Jan, Y.N., and Jan, L.Y. (1989).  Genes involved in early neural development of Drosophila.  In The Assembly of the Nervous System. 47th Symposium of Soc. of Dev. Biology, pp. 1-16. Alan R. Liss, Inc., New York.  

  44. Murre, C., Schonleber McCaw, P., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B., Weintraub, H., and Baltimore, D. (1989).  Heterodimers of helix-loop-helix proteins bind specifically to a common DNA sequence.  Cell 58:537-544.  [PubMed]

  45. Caudy, M., Vaessin, H., Brand, M., Tuma, R., Jan, L.Y., and Jan, Y.N. (1988).  daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.  Cell 55:1061-1067. PMID: 3203380.  [PubMed]

  46. Dambly-Chaudiere, C., Ghysen, A., Jan, L.Y., and Jan, Y.N. (1988).  The determination of sense organs in Drosophila: interaction of scute with daughterless.  Roux's Arch. Dev. Biol. 197:419-423.  

  47. Caudy, M., Grell, E., Dambly-Chaudiere, C., Ghysen, A., Jan, L.Y., and Jan, Y.N. (1988).  The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.  Genes Dev. 2:843-852.  [PubMed]

  48. Blochlinger, K.B., Bodmer, R., Jack, J., Jan, L.Y., and Jan, Y.N. (1988).  Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila.  Nature 333:629-635.  [PubMed]

  49. Bodmer, R., Jan Barbel, S., Shepherd, S., Jack, J.W., Jan, L.Y., and Jan, Y.N. (1987).  Transformation of sensory organs by mutations of the cut locus of Drosophila melanogaster.  Cell 51: 293-307.  [PubMed]

Asymmetric division and neural stem cell development

  1. Zhu, S., Barshow, S., Wildonger, J., Jan, L.Y., and Jan, Y.N. (2011). Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains. PNAS USA 108: 20615-20. PMCID: PMC3251047[PubMedCentral]

  2. Ouyang, Y., Petritsch, C., Wen, H., Jan, L., Jan, Y.N., and Lu, B. (2011) Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development 138:2185-96. PMCID: PMC3091490. [PubMedCentral]

  3. Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., and Jan, Y.N.  (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127:1253-1264.  [PubMed]

  4. Yu, F., Kuo, C.T., and Jan, Y.N. (2006). Drosophila neuroblast asymmetric cell division: recent advances and implications for stem cell biology. Neuron 51:13-20.  [PubMed]

  5. Kuo, C.T., and Jan, Y.N. (2005). The hand that rocks the spindle. Nat. Cell Biol. 7:858-859.  [PubMed]

  6. Roegiers, F., Jan, L.Y., and Jan, Y.N. (2005). Regulation of membrane localization of sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol. Biol. Cell. 16:3480-3487.  [PubMed]

  7. Lai, E.C., Roegiers, F., Qin, X., Jan, Y.N., and Rubin, G.M. (2005). The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132:2319-2332.  [PubMed]

  8. Roegiers, F., and Jan, Y.N. (2004). Asymmetric cell division. Curr. Opin. Cell Biol. 16:195-205.  [PubMed]

  9. Li, H.-S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40:1105-1118. PMID: 14687546.  [PubMed]

  10. Justice, N.J., Roegiers, F.R., Jan, L.Y., and Jan, Y.N. (2003). Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage. Curr. Biol. 13:778-783.  [PubMed]

  11. Justice, N.J., and Jan, Y.N. (2003). A lethal giant kinase in cell polarity. Nat. Cell Biol. 5:273-274.  [PubMed]

  12. Petritsch, C., Tavosanis, G., Turck, C.W., Jan, L.Y., and Jan, Y.N. (2003).  The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.  Dev. Cell 4, 273-281.  [PubMed]

  13. Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N., and Zhong, W. (2002).  Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.  Nature 419:929-934.  [PubMed]

  14. Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002).  Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.  Development 129:4843-4853.  [PDF]

  15. Jan, Y.N., and Jan, L.Y. (2001).  Asymmetric cell division in the Drosophila nervous system.  Nature Revs. Neurosci. 2:772-779.  [PubMed]

  16. Hong, Y., Stronach, B., Perrimon, N., Jan, L.Y., and Jan, Y.N. (2001).  Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.  Nature 414:634-638.  [PubMed]

  17. Roegiers, F., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (2001).  Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.  Proc. Natl. Acad. Sci USA 98:14469-14474.  [PDF]

  18. Sun, T.-Q., Lu, B., Feng, J.-J., Reinhard, C., Jan, Y.N., Frantl, W.J., and Williams, L.T. (2001).  PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signaling.  Nature Cell Biol. 3:628-636.  [PubMed]

  19. Lu, B., Roegiers, F., Jan, L.Y., and Jan, Y.N. (2001).  Adherens junctions inhibit asymmetric division in the Drosophila epithelium.  Nature 409:522-525.  [PubMed]

  20. Roegiers, F., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (2001).  Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage.  Nature Cell Biol. 3:58-67.  [PubMed]

  21. Lu, B., Jan, L.Y., and Jan, Y.N. (2000).  Control of Cell Divisions in the Nervous System: Symmetry and Asymmetry.  Annu. Rev. Neurosci. 23:531-556.  [PubMed]

  22. Jan, Y.N., and Jan, L.Y. (2000).  Polarity in cell division: What frames they fearful asymmetry?  Cell:599-602.  [PubMed]

  23. Jan, Y.N., and Jan, L.Y. (1999).  Asymmetry across species.  Nature Cell Biol. 1:E42-E44.  [PubMed]

  24. Lu, B., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1999).  Modes of protein movement that lead to the asymmetric localization of Partner of numb during Drosophila neuroblast division.  Molecul. Cell 4:883-891.  [PubMed]

  25. Lu, B., Usui, T., Uemura, T., Jan, L., and Jan, Y.N. (1999).  Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.  Curr. Biol. 9:1247-1250.  [PubMed]

  26. Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1999).  Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization.  Curr. Biol. 9:155-158.  [PubMed]

  27. Lu, B., Rothenberg, M., Jan, L.Y., and Jan, Y.N. (1998).  Partner of Numb, a novel protein that colocalizes with Numb during mitosis, directs Numb asymmetric localization in Drosophila neural and muscle progenitors.  Cell 95:225-235. PMID: 9790529.  [PubMed]

  28. Shen, C.-P., Knoblich, J.A., Chan, Y.-M., Jiang, M.-M., Jan, L.Y., and Jan, Y.N. (1998).  Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila.  Genes Dev. 12:1837-1846.  [PDF]

  29. Zeng C., Younger-Shepherd S., Jan L.Y., and Jan Y.N. (1998).  Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage.  Genes Dev. 12:1086-1091.  [PDF]

  30. Chien, C.-T., Wang, S., Rothenberg, M., Jan, L.Y., and Jan, Y.N. (1998).  Numb-associated kinase interacts with the phosphotyrosine binding domain of Numb and antagonizes the function of Numb in vivo.  Mol. Cell. Biol. 18: 598-607.  [PDF]

  31. Lu, B., Jan, L.Y., and Jan, Y.N. (1998).  Asymmetric cell division: lessons from flies and worms.  Curr. Opin Genet. Dev. 8:392-399.  [PubMed]

  32. Jan, Y.N., and Jan, L.Y. (1998).  Asymmetric Cell Division.  Nature, 392:775-778.  [PubMed]

  33. Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1997).  Asymmetric Segregation of the Drosophila Numb Protein during Mitosis: Facts and Speculations.  Cold Spring Harbor Symposia on Quantitative Biology, LXII:71-77.  [PubMed]

  34. Wang, S., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1997).  Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of Hairless.  Development 124:4435-4446.  [PDF]

  35. Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1997).  The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization.  Proc. Natl. Acad. Sci. USA 94:13005-13010.  [PDF]

  36. Shen, C.P., Jan, L.Y., and Jan, Y.N. (1997).  Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila.  Cell 90:449-458. PMID: 9267025.  [PubMed]

  37. Frise, E., Knoblich, J.A., Younger-Shepherd, S., Jan, L.Y., and Jan, Y.N. (1996).  The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.  Proc. Natl. Acad. Sci. USA 93:11925-11932.  [PDF]

  38. Kraut, R., Chia, W., Jan, L.Y., Jan, Y.N., and Knoblich, J.A. (1996).  Role of inscuteable in orienting asymmetric cell divisions in Drosophila.  Nature 383:50-55. PMID: 8779714.  [PubMed]

  39. Guo, M., Jan, L.Y., and Jan, Y.N. (1996).  Control of daughter cell fates during asymmetric division; interaction of Numb and Notch.  Neuron 17:27-41. PMID: 8755476.  [PubMed]

  40. Jan, Y.N., and Jan, L.Y. (1995).  Maggot's hair and bug's eye: role of cell interactions and intrinsic factors in cell fate specification.  Neuron 14:1-5.  [PubMed]

  41. Knoblich, J.A., Jan, L.Y., and Jan, Y.N. (1995).  Asymmetric segregation of Numb and Prospero during cell division.  Nature 377:624-627. PMID: 7566172.  [PubMed]

  42. Guo, M., Bier, E., Jan, L.Y., and Jan, Y.N. (1995).  tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.  Neuron 14:913-925.  [PubMed]

  43. Rhyu, M.S., Jan, L.Y., and Jan, Y.N. (1994).  Asymmetric distribution of numb protein during division of the Sensory Organ Precursor cell confers distinct fates to daughter cells.  Cell 76:477-491. PMID: 8324823.  [PubMed]

  44. Vaessin, H., Grell, E., Wolff, E., Bier, E., Jan, L.Y., and Jan, Y.N. (1991).  prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila.  Cell 67: 941-953. PMID: 1720353.  [PubMed]

  45. Bodmer, R., Carretto, R., and Jan, Y.N. (1989).  Neurogenesis of the Peripheral Nervous System in Drosophila Embryos: DNA replication Patterns and Cell lineages.  Neuron 3:21-32.  [PubMed]

  46. Uemura, T., Shepherd, S., Ackerman, L., Jan, L.Y., and Jan, Y.N. (1989).  numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryo.  Cell 58:349-360. PMID: 2752427.  [PubMed]

Oogenesis and pole cell development

  1. Abdelilah-Seyfried, S., Cox, D.N., and Jan, Y.N. (2003).  Bazooka is a permissive factor for the invasive behavior of Discs large tumor cells in Drosophila ovarian follicular epithelia.  Development 130:1927-1935.  [PDF]

  2. Cox, D.N., Abdelilah Seyfried, S., Jan, L.Y., and Jan, Y.N. (2001).  Bazooka and atypical protein kinase C are required to regulate oocyte differenation in the Drosophila ovary.  Proc. Natl. Acad. Sci USA 98:14475-14480.  [PDF]

  3. Cox, D.N., Lu, B.-W., Sun, T.-Q., Williams, L.T., and Jan, Y.N. (2001).  Drosophila par-1 is required for oocyte differentiation and microtubule organization.  Curr. Biol. 11:75-87.  [PubMed]

  4. Roegiers, F., and Jan, Y.N. (2000).  Staufen: a common component of mRNA transport in oocytes and neurons?  Trends Cell Biol. 10: 220-224.  [PubMed]

  5. Clark, I.E., Jan, L.Y., and Jan, Y.N. (1997).  Reciprocal localization of nod and kinesin fusion proteins indicates microtubule polarity in Drosophila oocyte, epithelium, neuron and muscle.  Development 124:461-470.  [PDF]

  6. Jongens, T.A., Ackerman, L.D., Swedlow, J.R., Jan, L.Y., and Jan, Y.N. (1994).  Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila.  Genes Dev. 8:2123-2136.  [PubMed]

  7. Clark, I., Giniger, E., Ruohola-Baker, H., Jan, L.Y., and Jan, Y.N. (1994).  Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.  Curr. Biol. 4:289-300.  [PubMed]

  8. Ruohola-Baker, H., Jan, L.Y., and Jan, Y.N. (1994).  The role of gene cassettes in axis formation during Drosophila oogenesis.  Trends Genet. 10:89-94.  [PubMed]

  9. Siegel, V., Jongens, T.A., Jan, L.Y., and Jan, Y.N. (1993).  pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber.  Development 119:1187-1202.  [PDF]

  10. Theurkauf, W.E., Alberts, B.M., Jan, Y.N., and Jongens, T.A. (1993).  A central role for microtubules in the differentiation of Drosophila oocytes.  Development 118:1169-1180.  [PDF]

  11. Ruohola-Baker, H., Grell, E., Chou, T.B., Baker, D., Jan, L.Y., and Jan, Y.N. (1993).  Spatially localized Rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis.  Cell 73:953-965.  [PubMed]

  12. Jongens, T.A., Hay, B., Jan, L.Y., and Jan, Y.N. (1992).  The germ cell-less gene product: A posteriorly localized component necessary for germ cell development in Drosophila.  Cell 70:569-584.  [PubMed]

  13. Ruohola, H., Bremer, K.A., Baker, D., Swedlowe, J.R., Jan, L.Y., and Jan, Y.N. (1991).  Role of neurogenic genes in establishment of follicle cell fate and oocyte polarity during oogenesis in Drosophila.  Cell 66:433-449.  [PubMed]

  14. Hay, B., Jan, L.Y., and Jan, Y.N. (1990). Localization of vasa, a component of Drosophila polar granules, in maternal effect mutants that alter embryonic anteroposterior polarity.  Development 109:425-433.  [PubMed]

  15. Hay, B., Jan, L.Y., and Jan, Y.N. (1988).  A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases.  Cell 55:577-587.  [PubMed]

  16. Hay, B., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1988).  Identification of a component of Drosophila polar granules.  Development 103: 625-640.  [PubMed]

Genomics

  1. Parrish, J.Z., Kim, C.C., Tang, L., Bergquist, S., Want, T., Derisi, J.l., Jan, L.Y., Jan, Y.N., and Davis, G.W. (2014). Krüppel mediates the selective rebalancing of ion channel expression. Neuron 82:537-44. PMID: 24811378. [PubMedCentral]

  2. McCarroll, S.A., Murphy, C.T., Zou, S., Pletcher, S.D., Chin, C.-S., Jan, Y.N., Kenyon, C., Bargmann, C.I., and Li, H. (2004). Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nature Genetics 36:197-204.  [PubMed]

  3. Zou, S., Meadows, S., Sharp, L., Jan, L.Y., and Jan, Y.N. (2000).  Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.  Proc. Natl. Acad. Sci. USA 97: 13726-13731.  [PDF]

  4. Moore, A.W., Barbel, S., Jan, L.Y., and Jan, Y.N. (2000).  A genomewide survey of basic helix-loop-helix factors in Drosophila.  Proc. Natl. Acad. Sci. USA 97: 10436-10441.  [PDF]

Vertebrate homologs

  1. Ultanir, S.K., Hertz, N.T., Li, G., Ge, W.P., Burlingame, A.L., Pleasure, S.J., Shokat, K.M., Jan, L.Y., and Jan, Y.N. (2012) Chemical Genetic Identification of NDR1/2 Kinase Substrates AAK1 and Rabin8 Uncovers Their Roles in Dendrite Arborization and Spine Development. Neuron 73:1127-1142. PMCID: PMC3333840. [PDF]

  2. Bultje, R.S., Castaneda-Castellanos, D.R., Jan, L.Y., Jan, Y.N., Kriegstein, A.R., and Shi, S.H. (2009) Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 63:189-202.  PMCID: PMC2736606. [PubMed]

  3. Koo, B.K., Yoon, M.J., Yoon, K.J., Im, S.K., Kim, Y.Y., Kim, C.H., Suh, P.G., Jan, Y.N., and Kong, Y.Y. (2007). An obligatory role of mind bomb-1 in notch signaling of Mammalian development. PLoS ONE. 2:e1221.  [PubMed]

  4. Rasin, M.R., Gazula, V.R., Breunig, J.J., Kwan, K.Y., Johnson, M.B., Liu-Chen, S., Li, H.S., Jan, L.Y., Jan, Y.N., Rakic, P., and Sestan, N. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat. Neurosci. 10:819-827.  [PubMed]

  5. Kuo, C.T., Mirzadeh, Z., Soriano-Navarro, M., Rasin, M., Wang, D., Shen, J., Sestan, N., Garcia-Verdugo, J., Alvarez-Buylla, A., Jan, L.Y., and Jan, Y.N.  (2006). Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127:1253-1264.  [PubMed]

  6. Anderson, A.C., Kitchens, E.A., Chan, S.W., Hill, C. St., Jan, Y.N., Zhong, W., and Robey, E.A. (2005). The Notch regulator numb links the Notch and TCR signaling pathways. J. Immunol. 174:890-897.  [PubMed]

  7. Huang, E.J., Li, H.h., Tang, A.A., Wiggins, A.K., Neve, R.L., Zhong, W., Jan, L.Y., and Jan, Y.N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19:138-151.  [PubMed]

  8. Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity. Curr. Biol. 14:2025-2032.  [PubMed]

  9. Shi, S.-H., Cox, D.N., Wang, D., Jan, L.Y., and Jan, Y.N. (2004). Control of dendrite arborization by an Ig family member, dendrite arborization and synapse maturation 1 (Dasm1). Proc. Natl. Acad. Sci. USA 101:13341-13345.  [PubMed]

  10. Shi, S.-H., Cheng, T., Jan, L.Y., and Jan, Y.N. (2004). The immunoglobulin family member dendrite arborization and synapse maturation 1 (Dasm1) controls excitatory synapse maturation. Proc. Natl. Acad. Sci. USA 101:13346-13351.  [PDF]

  11. Li, H.-S., Wang, D., Shen, Q., Schonemann, M.D., Gorski, J.A., Jones, K.R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40:1105-1118.  [PubMed]

  12. Shi, S.-H., Jan, L.Y., and Jan, Y.-N. (2003).  Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity.  Cell 112:63-75. PMID: 12526794 [PubMed]

  13. Petersen, P.H., Zou, K., Hwang, J.K., Jan, Y.N., and Zhong, W. (2002).  Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.  Nature 419:929-934.  [PubMed]

  14. Donovan, J., Kordylewska, A., Jan, Y., and Utset, M. (2002).  Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice.  Curr. Biol. 12:1605-1610.  [PubMed]

  15. Shen, Q., Zhong, W., Jan, Y.N., and Temple, S. (2002).  Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts.  Development 129:4843-4853.  [PDF]

  16. Horne-Badovinac, S., Lin, D., Waldron, S., Schwarz, M., Mbamalu, G., Pawson, T., Jan, Y.-N., Stainier, D.Y.R., and Abdelilah-Seyfried, S. (2001).  Positional cloning of heart and soul reveals multiple roles for PKCλ in zebrafish organogenesis.  Curr. Biol. 11:1492-1502.  [PubMed]

  17. Ruan, Y., Tecott, L., Jiang, M.-M., Jan, L.Y., and Jan, Y.N. (2001).  Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.  Proc. Natl. Acad. Sci. USA 98: 9907-9912.  [PDF]

  18. Zhong, W., Jiang, M.-M., Schonemann, M.D., Meneses, J.J., Pedersen, R.A., Jan, L.Y., and Jan, Y.N. (2000).  Mouse numb is an essential gene involved in cortical neurogenesis.  Proc. Natl. Acad. Sci. 97:6844-6849.  [PDF]

  19. Kanekar, S., Perron, M., Dorsky, R., Harris, W.A., Jan, L.Y., Jan, Y.N., and Vetter, M.L. (1997).  Xath5 participates in a network of bHLH genes in the developing Xenopus retina.  Neuron 19:981-994.  [PubMed]

  20. Zhong, W., Jiang, M.M., Weinmaster, G., Jan, L.Y., and Jan, Y.N. (1997).  Differential expression of mammalian Numb, Numblike and Notch1 suggest distinct roles during mouse cortical neurogenesis.  Development 124:1887-1897.  [PDF]

  21. Zhong, W., Feder, J.N., Jiang, M.M., Jan, L.Y. and Jan, Y.N. (1996).  Asymmetric localization of a mammalian Numb homologue during mouse cortical neurogenesis.  Neuron 17:43-53.  [PubMed]

  22. Feder, J.N., Li, L., Jan, L.Y., and Jan, Y.N. (1994).  Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene hairy.  Genomics 20:56-61.  [PubMed]

  23. Feder, J.N., Jan, L.Y., and Jan, Y.N. (1993).  A rat gene with sequence homology to the Drosophila gene hairy is rapidly induced by growth factors known to influence neuronal differentiation.  Mol. Cell Biol. 13:105-113.  [PDF]

Miscellaneous

  1. Yu, D., Gustafson, W.C., Han, C., Lafaye, C., Noirclerc-Savoye, M., Ge, W.P. Thayer, D.A., Huang, H., Kornberg, T.B. Royant, A., Jan, L.Y., Jan, Y.N., Weiss, W.A., and Shu X. (2014). An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging. Nature Comm 5, Article 3626, published 5/15/14. PMCID: PMC4077998. [PDF]

  2. Fieni, F., Bae Lee, S., Jan, Y.N., and Kirichok, Y. (2012) Activity of the mitochondrial calcium uniporter varies greatly between tissues. Nat Commun. 3:1317. PMCID: PMC3818247. [PubMedCentral]

Reminiscence

  1. Jan, L.Y. (2014). Q & A Lily Jan. Curr Biol. Mar 24:R212-3. PMID: 24795915. [PDF]

  2. Jan, Y.N., and Jan, L.Y. (2014). The History of Neuroscience in Autobiography. Society of Neuroscience, History of Neuroscience, Autobiographical Chapters. Volume 8. [PDF]

  3. Jan, Y.N. (2012) Yoshiki Hotta's influence. J Neurogenet. 26:3-4. PMID:22263807. [PDF]

  4. Jan, Y.N. and Jan., L. (2008). Retrospective: Seymour Benzer (1921-2007). Science 319:45. PMID: 18174427.  [PubMed]

  5. Jan, Y.N. (2003). Q & A. Curr. Biol. 13:R378-R379  [PubMed]

  6. Jan, Y.N. (2000).  Curious Seymour (Book Review).  Cell 101:123-125.  

  7. Jan, Y.N., and Jan, L.Y. (2000).  Humble starts and conserved themes in neurogenetic studies.  Harvey Lecture 94: 21-45.  [PubMed]

  8. Jan, Y.N., and Jan, L.Y. (1998).  Serendipity, the principle of limited sloppiness, and neural development.  Int. J. Dev. Biol. 42:531-533.  [PubMed]

  9. Jan, Y.N. (1997).  Pre-empting the arrival of a dark lord (correspondence).  Nature 389:665.  [PubMed]

  10. Jan, Y.N., and Jan, L.Y. (1990).  In Rememberance of Stephen W. Kuffler, ed. U.J. McMahan, pp. 47-50.  Sinauer Inc., Sunderland, MA.  

 

 
   
      Home · Function Group · Development Group · All Jan Publications · People· Contact