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S E L E C T    P U B L I C A T I O N S   (by topic)

Transmitter actions and synapses
Voltage-gated potassium channels
Inwardly rectifying potassium channels
Trafficking channels and receptors
Channel families-evolution
New fluorescent probes for studying channel function
Potassium channels and disease
Calcium-activated chloride channels
Glia

 

Transmitter actions and synapses

  1. Thayer, D.A., Jan, Y.N., Jan, L.Y. (2013) Increased neuronal activity fragments the Golgi complex. PNAS USA 2013 Jan 7. PMID: 23297202. [PubMedCentral]

  2. Lee, H.Y., Ge, W.P., Huang, W., He, Y., Wang, G.X., Rowson-Baldwin, A., Smith, S.J., Jan, Y.N., and Jan, L.Y. (2011) Bidirectional Regulation of Dendritic voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein. Neuron 72:630-642. PMID: 22099464. [PDF]

  3. Lee, HH., Jan, LY., Jan, YN. (2009) Drosophila IKK-related kinase Ik2 and Katanin p60-like 1 regulate dendrite pruning of sensory neuron during metamorphosis. Proc Natl Acad Sci USA. 106(15):6363-68. PMCID: PMC2661847 [PubMedCentral]

  4. Chung, HJ., Qian, X., Ehlers, M., Jan, YN., Jan, LY. (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci USA. 106(2):629-34. PMCID: 2613039 [PubMedCentral]

  5. Chung, HJ., Ge, WP., Qian, X., Wiser, O., Jan, YN>, Jan, LY. (2009) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term protentiation. Proc Natl Acad Sci USA. 106(2):635-40. PMCID: PMC2613041 [PubMedCentral]

  6. Chang, W., Tu, C., Rodriguez, L., Chen, T.H., Gassmann, M., Bettler, B., Margeta, M., Jan, L.Y., and Shoback, D. (2007). Complex formation with the type B gamma-aminobutyric acid recepter: Studies with HEK-293 cells and neurons. J. Biol. Chem. 282:25030-250.  [PDF]

  7. Ja, W.W., Wiser, O., Austin, R.J., Jan, L.Y., and Roberts, R.W., (2006). Turning g proteins on and off using peptide ligands. ACS Chem. Biol. 1:570-574.  [PubMed]

  8. Raab-Graham, K.F., Haddick, P.C., Jan, Y.N., and Jan, L.Y. (2006). Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314:144-148.  [Full Text]

  9. Wiser, O., Qian, X., Ehlers, M., Ja, W.W., Roberts, R.W., Reuveny, E., Jan, Y.N., and Jan, L.Y. (2006). Modulation of Basal and Receptor-Induced GIRK Potassium Channel Activity and Neuronal Excitability by the Mammalian PINS Homolog LGN. Neuron 50:561-573.  [PubMed]

  10. Jan, L.Y., and Siegelbaum, S.A. (2005). Signaling mechanisms. Curr. Opin. Neurobiol. 15:253-256.  

  11. Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2001).  Function of GB1 and GB2 subunits in G protein coupling of GABAB receptors. Proc. Natl. Acad. Sci USA 98:14649-14654.  [PDF]

  12. Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2001).  Ligand-induced signal transduction within heterodimeric GABAB receptor. Proc. Natl. Acad. Sci. USA 98:14643-14648.  [PDF]

  13. Jan, L.Y., and Stevens, C.F. (2000). Signalling mechanisms. A decade of signaling. Curr. Opin. Neurobiol. 10:625-630.  [PubMed]

  14. Margeta-Mitrovic, M., Mitrovic, I., Riley, R.C., Jan, L.Y., and Basbaum, A.I. (1999). Immunohistochemical localization of GABAB receptors in the rat central nervous system. J. Comp. Neurol. 405:299-321.  [PubMed]

  15. Zerangue, N., and Jan, L.Y. (1998). G-protein signaling: fine-tuning signaling kinetics.   Curr.Biol. 8:R313-R316.  [PubMed]

  16. Jan, L.Y., and Jan, Y.N. (1997).  Receptor-regulated ion channels.  Curr. Opin. Cell Biol. 9:155-160  [PubMed]

  17. Liu, H., Wang, H., Sheng, M., Jan, Y.N., Jan, L.Y., and Basbaum, A.I. (1994).  Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn.  Proc. Natl. Acad. Sci. USA 91:8383-8387.  [PDF]

  18. Sheng, M., Cummings, J., Roldan, L.A., Jan, Y.N., and Jan, L.Y. (1994).  Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.  Nature 368: 144-147.  [PubMed]

  19. Bowers, C., Jan, L.Y., and Jan, Y.N. (1986).  A substance P-like peptide in bullfrog autonomic nerve terminals-Anatomy, biochemistry and physiology.  Neuroscience 19:343-356.  [PubMed]

  20. Jan, L.Y., Papazian, D., Timpe, L., O'Farrell, P., and Jan, Y.N. (1985).  Application of Drosophila molecular genetics in the study of neural function-studies of the Shaker locus for a potassium channel.  Trends Neurosci. 8:2334-238.

  21. Jan, L.Y., and Jan, Y.N. (1982).  Peptidergic transmission in sympathetic ganglia of the frog.   J. Physiol. 327:219-246.  [PubMed]

  22. Jan, L.Y., Jan, Y.N., and Brownfield, M.S. (1980).  Peptidergic transmitters in synaptic boutons of sympathetic ganglia.  Nature 288:380-382.[PubMed]

  23. Jan, Y.N., Jan, L.Y., and Kuffler, S.W. (1980).  Further evidence for peptidergic transmission in sympathetic ganglia.  Proc. Natl. Acad. Sci. USA 77:5008-5012.  [PDF]

  24. Jan, Y.N., Jan, L.Y., and Kuffler, S.W. (1979).  A peptide as a possible transmitter in sympathetic ganglia of the frog.  Proc. Natl. Acad. Sci. USA 76:1501-1505.  [PDF]

  25. Heuser, J.E., Reese, T.S., Dennis, M.J., Jan, Y.N., Jan, L.Y., and Evans, L. (1979).   Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release.  J. Cell Biol. 81:275-300.

  26. Jan, Y.N., and Jan, L.Y. (1978).  Genetic dissection of short-term and long-term facilitation in Drosophila.  Proc. Natl. Acad. Sci. USA 75:515-519.  [PDF]

  27. Jan, L.Y., and Jan, Y.N. (1976).  L-glutamate as an excitatory transmitter at Drosophila larval neuromuscular junction.  J. Physiol. 262:215-236.  [PubMed]

  28. Jan, L.Y., and Jan, Y.N. (1976).  Properties of the larval neuromuscular junction in Drosophila melanogaster.  J. Physiol. 262:189-214.  [PubMed]

 

Voltage-gated potassium channels

  1. Huang, X., Dubuc, A.M., Hashizume, R., Berg, J., He, Y., Wang, J., Chiang, C., Cooper, M.K., Northcott, P.A., Taylor, M.D., Barnes, M.J., Tihan, T., Chen, J., Hackett, C.S., Weiss, W.A., James, C.D., Rowitch, D.H., Shuman, M.A., Jan, Y.N., and Jan, L.Y. (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 26:1780-96. PMID: 22855790. [PubMedCentral]

  2. Yang, S.B., Mclemore, K.D.,Tasic, B., Luo, L., Jan, Y.N., and Jan, L.Y. (2012) Kv1.1-dependent Control of Hippocampal Neuron Number as Revealed by Mosaic Analysis with Double Markers (MADM). J Physiol. 590:2645-58. PMID: 22411008. [PubMedCentral]

  3. Lee, H.Y., Ge, W.P., Huang, W., He, Y., Wang, G.X., Rowson-Baldwin, A., Smith, S.J., Jan, Y.N., and Jan, L.Y. (2011) Bidirectional Regulation of Dendritic voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein. Neuron 72:630-642. PMCID: PMC3433402. [PDF]

  4. Grabe, M., Lai, H.C., Jain, M., Jan, Y.N., and Jan, L.Y. (2007).  Structure prediction for the down state of a potassium channel voltage sensor. Nature 445, 550-553. PMID: 17187053

  5. Gu, C., Zhou, W., Puthenveedu, M.A., Xu, M., Jan, Y.N., and Jan, L.Y. (2006). The Microtubule Plus-End Tracking Protein EB1 Is Required for Kv1 Voltage-Gated K(+) Channel Axonal Targeting. Neuron 52:803-816.

  6. Lai, H.C., and Jan, L.Y. (2006). The distribution and targeting of neuronal voltage-gated ion channels. Nat. Rev. Neurosci. 7:548-562.  [PubMed]

  7. Chung, H.J., Jan, Y.N., and Jan, L.Y. (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc. Natl. Acad. Sci. USA 103:8870-8875.  [PubMed]

  8. Surti, T.S., Huang, L., Jan, Y.N., Jan, L.Y., and Cooper, E.C. (2005). Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc. Natl. Acad. Sci. USA 102:17828-17833.  [PubMed]  

  9. Lai, H.C., Grabe, M., Jan, Y.N., and Jan, L.Y. (2005). The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron 47:395-406. PMID: 16055063.  [PubMed]

  10. Ionescu-Zanetti, C., Shaw, R.M., Seo, J., Jan, Y.N., Jan, L.Y., and Lee, L.P. (2005). Mammalian electrophysiology on a microfluidic platform. Proc. Natl. Acad. Sci. U.S.A. 102:9112-9117.  [PubMed]

  11. Surti, T.S., and Jan, L.Y. (2005). A potassium channel, the M-channel, as a therapeutic target. Curr. Opin. Investig. Drugs 6:704-711.  [PubMed]

  12. Grabe, M., Lecar, H., Jan, Y.N., and Jan, L.Y. (2004). A quantitative assessment of models for voltage-dependent gating of ion channels. Proc. Natl. Acad. Sci. USA 101:17640-17645.  [PubMed]

  13. Gutman, G.A., Chandy, K.G., Adelman, J.P., Aiyar, J., Bayliss, D.A., Clapham, D.E., Covarriubias, M., Desir, G.V., Furuichi, K., Ganetzky, B., Garcia, M.L., Grissmer, S., Jan, L.Y., Karschin, A., Kim, D., Kuperschmidt, S., Kurachi, Y., Lazdunski, M., Lesage, F., Lester, H.A., McKinnon, D., Nichols, C.G., O'Kelly, I., Robbins, J., Robertson, G.A., Rudy, B., Sanguinetti. M,, Seino, S., Stuehmer, W., Tamkun, M.M., Vandenberg, C.A., Wei, A., Wulff, H., and Wymore, R.S. (2003). International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev. 55:583-586.  [PDF]

  14. Cohen, B., Grabe, M., and Jan, L.Y. (2003). Answers and questions from the KvAP Structures. Neuron 39:395-400.  [PubMed]

  15. Cooper, E.C., and Jan, L.Y. (2003). M-channels: neurological diseases, neuromodulation, and drug development. Arch. Neurol. 60:496-500.  [PubMed]

  16. Yi, B.A., Minor, D.L., Jr., Lin, Y.-F., Jan, Y.N., and Jan, L.Y. (2001).  Controlling potassium channel activities: interplay between the membrane and intracellular factors.  Proc. Natl. Acad. Sci. USA 98:11016-11023.  [PubMed]

  17. Cooper, E.C., Harrington, E., Jan, Y.N., and Jan, L.Y. (2001).  M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain.  J. Neurosci. 21:9529-9540.  [PDF]

  18. Minor Jr., D.L., Lin, Y.-F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y., and Berger, J.M. (2000).  The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel.  Cell 102:657-670.  [PubMed]

  19. Yi, B.A., and Jan, L.Y. (2000). Taking apart the gating of voltage-gated K+ channels.  Neuron 27:423-425.  [PubMed]

  20. Cooper, E.C., Aldape, K.D., Abosch, A., Barbaro, N.M. Berger, M.S. Peacock, W.S. Jan, Y.N. and Jan, L.Y. (2000) Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.  Proc. Natl. Acad. Sci. USA 97: 4914-4919.  [PDF]

  21. Zerangue, N. Jan, Y.N., and Jan, L.Y. (2000) An artificial tetramerization domain restores efficient assembly of functional Shaker channels lacking T1.  Proc. Natl. Acad. Sci. USA 97:3591-3595.  [PDF]

  22. Cooper, E.C., and Jan, L.Y. (1999). Ion channel genes and human neurological disease: recent progress, prospects, and challenges.  Proc. Natl. Acad. Sci. USA 96:4759-4766.  [PDF] [PubMed]

  23. Cooper, E.C., Milroy, A., Jan, Y.N., Jan, L.Y., and Lowenstein, D.H. (1998).  Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus.  J. Neurosci. 18:955-974.  [PDF]

  24. Jan, L.Y., and Jan, Y.N. (1997).  Ways and means for left shifts in the MaxiK channel.  Proc. Natl. Acad. Sci. USA 94:13383-13385.  [PDF]

  25. Jan, L.Y., and Jan, Y.N. (1997).  Voltage-gated and inwardly rectifying potassium channels. J. Physiol. 505:267-282.  [PDF]

  26. Xu, J., Yu, W., Jan, Y.N., Jan, L.Y., and Li, M. (1995).  Assembly of voltage-gated potassium channels. Conserved hydrophilic motifs determine subfamily-specific interactions between the alpha-subunits.  J. Biol. Chem. 270:24761-24768.  [PDF]

  27. Klumpp, D.J., Song, E.J., Ito, S., Sheng, M.H., Jan, L.Y., and Pinto, L.H. (1995).   The Shaker-like potassium channels of the mouse rod bipolar call and their contributions to the membrane current.  J. Neurosci. 15:5004-5013.  [PDF]

  28. Sheng, M., Tsaur, M-L, Jan, Y.N., and Jan, L.Y. (1994). Contrasting subcellular localization of the Kv1.2 K+ channel subunit in different neurons of rat brain.  J. Neurosci. 14:2408-2417.  [PDF]

  29. Lopez, G., Jan, Y.N., and Jan, L.Y. (1994).  Evidence that the S6 segment of the Shaker voltage-gated K+ channel comprises part of the pore.  Nature 367: 179-182.  [PubMed]

  30. Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993).  The S4-S5 loop contributes to the ion selective pore of potassium channels.  Neuron 11:739-749.  [PubMed]

  31. Sheng, M., Liao, J., Jan, Y.N., and Jan, L.Y. (1993). Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.  Nature 365:72-75.  PMID: 8361540 [PubMed]

  32. Li, M., Jan, Y.N., and Jan, L.Y. (1992). Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker K+ channel.  Science 257:1225-1230.  PMID 1519059 [PubMed]

  33. Sheng, M., Tsaur, M-L, Jan, Y.N., and Jan, L.Y. (1992).  Subcellular Segregation of Two A-type K+ Channel Proteins in Rat Central Neurons.  Neuron 9:271-284.  [PubMed]

  34. Tsaur, M.L.,Sheng, M., Lowenstein, D.H., Jan, Y.N., and Jan, L.Y. (1992).  Differential expression of K+ channel mRNAs in the rat brain and down regulation in the hippocampus following seizures.  Neuron 8:1055-1067.  [PubMed]

  35. Jan, L.Y., and Y.N. Jan. (1992).  Structural elements involved in specific K+ channel functions.  Annu. Rev. Physiol. 54:537-555.  [PubMed]

  36. Isacoff, E.Y., Jan, Y.N., and Jan, L.Y. (1991).  Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel.  Nature 353:86-90.  [PubMed]

  37. Lopez, G.A., Jan, Y.N., and Jan, L.Y. (1991).  Hydrophobic Substitution Mutations in the S4 Sequence Alter Voltage-Dependent Gating in Shaker K+ Channels.  Neuron 7:327-336.  [PubMed]

  38. Baldwin, T.B., Tsaur, M-L, Lopez, G.A., Jan, Y.N., and Jan, L.Y. (1991).  Characterization of a mammalian K+ channel cDNA for an inactivating voltage-sensitive K+ channel.  Neuron 7:471-483.  [PubMed]

  39. Papazian, D.M., Timpe, L.C., Jan, Y.N., and Jan, L.Y. (1991).  Alteration of voltage-dependence of Shaker K+ channel by mutations in the S4 sequence.  Nature 349:305-310.  [PubMed]

  40. Klaiber, K., Williams, N., Roberts, T.M., Papazian, D.M., Jan, L.Y., and Miller, C. (1990).  Functional expression of Shaker K+ channels in a baculovirus-infected insect cell line.  Neuron 5:211-216.  [PubMed]

  41. Isacoff, E., Jan, Y.N., and Jan, L.Y. (1990).  Evidence for the formation of heteromulteric potassium channels in Xenopus oocytes.  Nature 345: 530-534.  PMID: 2112229 [PubMed]

  42. Schwarz, T.L., Papazian, D.M., Carretto, R.C., Jan, Y.N., and Jan, L.Y. (1990).   Immunological characterization of K+-channel components from the Shaker locus and the differential distribution of splicing variants in Drosophila.  Neuron 4:119-127.  [PubMed]

  43. Jan, L.Y., and Jan, Y.N. (1989). Voltage-sensitive ion channels. Cell 56:13-25.  [PubMed]

  44. Timpe, L.C., Jan, Y.N., and Jan, L.Y. (1988).  Four cDNA clones from the Shaker locus of Drosophila induce kinetically distinct A-type potassium currents in Xenopus oocytes.   Neuron 1:659-667.  [PubMed]

  45. Tempel, B.L, Jan, Y.N., and Jan, L.Y. (1988).  Cloning of a probable potassium channel from mouse brain.  Nature 332:837-839.  [PubMed]

  46. Timpe, L.C., Schwarz, T.L., Tempel, B.L, Papazian, D.M., Jan, Y.N., and Jan, L.Y. (1988).   Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes.  Nature 331:143-145.  [PubMed]

  47. Schwarz, T.L., Tempel, B.L, Papazian, D.M., Jan, Y.N., and Jan, L.Y. (1988).  Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.  Nature 331:137-142. PMID: 2448635.  [PubMed]

  48. Timpe, L.C., and Jan, L.Y. (1987).  Gene dosage and complementation analysis of the Shaker locus in Drosophila.  J. Neurosci. 7:1307-1317.  [PDF]

  49. Tempel, B.L., Papazian, D.M., Schwarz, T.L., Jan, Y.N., and Jan, L.Y. (1987).  Sequence of a probable K+ channel component in Drosophila deduced from Shaker cDNA.  Science 237:770-775.  [PubMed]

  50. Papazian, D.M., Schwarz, T.L., Tempel, B.L., Jan, Y.N., and Jan, L.Y. (1987).  Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.  Science 237:749-753.  PMID: 2441470 [PubMed]

  51. Jan, Y.N., Jan, L.Y., and Dennis, M.J. (1977).  Two mutations of synaptic  transmission in Drosophila.  Proc. Roy. Soc. Lond. B 198:87-108.  [PubMed]

 

Inwardly rectifying potassium channels

  1. Yang, S.B., Tien, A.C., Boddupalli, G., Xu, A.W., Jan, Y.N., and Jan, L.Y. (2012) Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons. Neuron 75: 425-436. PMID: 22884327. [PubMedCentral]

  2. Yang, S.B., Lee, H.Y., Young, D.M., Tien, A.C., Rowson-Baldwin, A., Shu, Y.Y., Jan, Y.N., and Jan, L.Y. (2012) Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med. PMCID: PMC3354320. [PubMedCentral]

  3. Zhou, W., Jan, LY. (2010) A Twist on Potassium Channel Gating. Cell 141(6):920-22. PMID: 20550927. [PDF]

  4. Chung, HJ., Qian, X., Ehlers, M., Jan, YN., Jan, LY. (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci USA. 106(2):629-34. PMCID: 2613039 [PubMedCentral]

  5. Chung, HJ., Ge, WP., Qian, X., Wiser, O., Jan, YN>, Jan, LY. (2009) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term protentiation. Proc Natl Acad Sci USA. 106(2):635-40. PMCID: PMC2613041 [PubMedCentral]

  6. Haass, F.A., Jonikas, M., Walter, P., Weissman, J.S., Jan, Y.N., Jan, L.Y., and Schuldiner, M. (2007). Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc. Natl. Acad. Sci. USA 104:18079-18084.  [PDF]

  7. Gong, Q., Weide, M., Huntsman, C., Xu, Z., Jan, L.Y., Ma D. (2007). Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling.  J. Biol. Chem. 17:13087-13097.  [PubMed]

  8. Raab-Graham, K.F., Haddick, P.C., Jan, Y.N., and Jan, L.Y. (2006). Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. Science 314:144-148.  PMID: 17023663 [Full Text]

  9. Grabe, M., Bichet, D., Qian, X., Jan, Y.N., and Jan, L.Y. (2006). K+ channel selectivity depends on kinetic as well as thermodynamic factors. Proc. Natl. Acad. Sci. USA 103:14361-14366.  [pdf]

  10. Bichet, D., Grabe, M., Jan, Y.N., and Jan, L.Y. (2006). Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc. Natl. Acad. Sci. USA 103:14355-14360.  [pdf]

  11. Wiser, O., Qian, X., Ehlers, M., Ja, W.W., Roberts, R.W., Reuveny, E., Jan, Y.N., and Jan, L.Y. (2006). Modulation of Basal and Receptor-Induced GIRK Potassium Channel Activity and Neuronal Excitability by the Mammalian PINS Homolog LGN. Neuron 50:561-573.  [PubMed]

  12. Kubo, Y., Adelman, J.P., Clapham, D.E., Jan, L.Y., Karschin, A., Kurachi, Y., Lazdunski, M., Nichols, C.G., Seino, S., and Vandenberg, C.A. (2005). International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol. Rev. 57:509-526.   [PubMed]

  13. Lin, Y.-F., Raab-Graham, K., Jan, Y.N., and Jan, L.Y. (2004). NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101:7799-7804.  [PDF]

  14. Bichet, D., Lin, Y.-F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N., and Jan, L.Y. (2004). Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci USA 101:4441-4446.  [PDF]

  15. Bichet, D., Haass, F.A., and Jan, L.Y. (2003). Merging functional studies with structures of inward-rectifier K+ channels. Nature Reviews Neuroscience 4:957-967.  [PubMed]

  16. Hu, K., Huang, C.S., Jan, Y.N. and Jan, L.Y. (2003)  ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C.  Neuron 38:417-432.  [PubMed]

  17. Mitrovic, I., Margeta-Mitrovic, M., Bade, S., Stoffel, M., Jan, L.Y., and Basbaum, A.I. (2003)  Contribution of GIRK2-mediated postsynaptic signaling to opiate and α2-adrenergic analgesia and analgesic sex differences.  Proc. Natl. Acad. Sci USA 100:271-276.  PMCID: PMC140949 [PDF]

  18. Ma, D., Zerangue, N. Raab-Graham, K., Fried, S.R., Jan, Y.N., and Jan, L.Y. (2002).  Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.  Neuron 33:715-729.  PMID: 11879649 [PubMed]

  19. Yi, B.A., Minor, D.L., Jr., Lin, Y.-F., Jan, Y.N., and Jan, L.Y. (2001).  Controlling potassium channel activities: interplay between the membrane and intracellular factors.  Proc. Natl. Acad. Sci. USA 98:11016-11023.  [PDF]

  20. Lu, T., Ting, A.Y., Mainland, J., Jan, L.Y., Schultz, P.G., and Yang, J. (2001). Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter. Nat. Neurosci. 4:239-246  [PubMed]

  21. Yi, B.A., Lin, Y.F., Jan, Y.N.. and Jan, L.Y. (2001).  Yeast screen for constitutively active mutant G protein-activated potassium channels.  Neuron 29:657-667. PMID: 11301025.  [PubMed]

  22. Ma, D., Zerangue, N., Lin, Y.-F., Collins, A., Yu, M., Jan, Y.N., and Jan, L.J.  (2001). Role of ER export signals in controlling surface potassium channel numbers.  Science 291:316-319.  [PubMed]

  23. Schwappach, B., Zerangue, N., Jan, Y.N. and Jan, L.Y. (2000).  Molecular basis for KATP assembly: Transmembrane interactions mediate association of a K+ channel with an ABC transporter.  Neuron 26: 155-167.  [PubMed]

  24. Lin, Y.F., Jan, Y.N. and Jan, L.Y. (2000).  Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells.  EMBO J. 19:942-955.  [PubMed]

  25. Zerangue, N., Schwappach, B., Jan, Y.N., and Jan, L.Y. (1999).  A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane KATP channels.  Neuron 22:537-548.  PMID 10197533 [PubMed]

  26. Minor, D.L. Jr., Masseling, S.J., Jan, Y.N., and Jan, L.Y. (1999).  Transmembrane structure of an inwardly rectifying potassium channel.  Cell 96:879-891.  [PubMed]

  27. Chuang, H.-h., Yu, M., Jan, Y.N., and Jan, L.Y. (1998).  Evidence that the nucleotide exchange and hydrolysis cycle of G-proteins causes acute desensitization of G-protein gated inward rectifier K+ channels.  Proc. Natl. Acad. Sci. USA 95:11727-11732.  [PDF]

  28. Ford, C.E., Skiba, N.P., Bae, H., Daaka, Y., Reuveny, E., Shekter, L.R., Rosal, R., Weng, G., Yang, C.-S., Iyengar, R., Miller, R.J., Jan, L.Y., Lefkowitz, R.J., and Hamm, H.E. (1998).  Molecular basis for interactions of G protein βγ subunits with effectors.  Science 280:1271-1274.  [PubMed]

  29. Lüscher, C., Jan, L.Y., Stoffel, M., Malenka, R.C., and Nicoll, R.A. (1997).  G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter action in hippocampal neurons.  Neuron 19:687-695.  [PubMed]

  30. Slesinger, P.A., Stoffel, M., Jan, Y.,,N. and Jan, L.Y. (1997).  Defective γ-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice.  Proc. Natl. Acad. Sci. USA 94:12210-12217.  [PDF]

  31. Chuang, H.H., Jan, Y.N., and Jan, L.Y. (1997).  Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium.  Cell 89:1121-1132.  PMID: 9215634 [PubMed]

  32. Collins, A. Chuang, H.H., Jan, Y.N., and Jan, L.Y. (1997),  Scanning mutagenesis of the putative transmembrane segments of Kir 2.1, an inward rectifier potassium channel.  Proc. Natl. Acad. Sci. USA 94:5456-5460.  [PDF]

  33. Huang, C.L., Jan, Y.,N., and Jan, L.Y. (1997).  Binding of the G protein βγ subunit to multiple regions of G protein-gated inward rectifying K+ channels.  FEBS Lett. 405:291-298.  [PubMed]

  34. Yang, J., Yu, M., Jan, Y.N., and Jan, L.Y. (1997).  Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel.  Proc. Natl. Acad. Sci. USA 94:1568-1572.  [PDF]

  35. Signorini, S., Liao, Y.J., Duncan, S.A., Jan, L.Y., and Stoffel, M. (1997).  Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2.  Proc. Natl. Acad. Sci. USA 94:923-927.  [PDF]

  36. Vivaudou, M., Chan, K.W., Sui, J.L., Jan, L.Y., Reuveny, E., and D.E. Logothetis (1997).  Probing the G-protein regulation of GIRK1 and GIRK4, the two subunits of the KACh channel, using functional homomeric mutants.  J. Biol. Chem. 272:31553-31560.  [PDF]

  37. Jan, L.Y., and Jan, Y.N. (1997).  Voltage-gated and inwardly rectifying potassium channels. J. Physiol. 505:267-282.  [PDF]

  38. Fakler, B., Schultz, J.H., Yang, J., Schulte, U., Brändle, U., Zenner, H.P., Jan, L.Y., and Ruppersberg, J.P. (1996).  Identification of a titratable lysine residue that determines sensitivity of kidney potassium channels (ROMK) to intracellular pH.  EMBO J. 15:4093-4099.  [PubMed]

  39. Liao, Y.J., Jan, Y.N., and Jan, L.Y. (1996).  Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brains.  J. Neurosci. 16:7137-7150.  [PDF]

  40. Tinker, A., Jan, Y.N., and Jan, L.Y. (1996).  Regions responsible for the assembly of inwardly rectifying potassium channels.  Cell 87:857-868.  PMID: 8945513 [PubMed]

  41. Slesinger, P.A., Patil, N. Liao Y.J., Jan, Y.N., Jan, L.Y., and Cox, D.R. (1996).  Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels.  Neuron 16: 321-331.  [PubMed]

  42. Reuveny, E. Jan, Y.N., and Jan, L.Y. (1996).  Contributions of a negatively charged residue in the hydrophobic domain of the IRK1 inwardly rectifying K+ channel to K+-selective permeation.  Biophys. J. 70: 754-761  [PubMed]

  43. Collins, A., German, M.S., Jan, Y.N., Jan, L.Y., and Zhao, B. (1996).  A strongly inwardly rectifying K+ channel that is sensitive to ATP.  J.Neurosci. 16:1-9.  [PubMed]

  44. Yang, J., Jan, Y.N., and Jan, L.Y. (1995).  Determination of the subunit stoichiometry of an inwardly rectifying potassium channel.  Neuron 15:1441-1447.  PMID: 8845166 [PubMed]

  45. Slesinger, P.A., Reuveny, E., Jan, Y.N., and Jan, L.Y. (1995).  Identification of structural elements involved in G protein gating of the GIRK1 potassium channel.  Neuron 15:1145-1156.  [PubMed]

  46. Huang, C-L., Slesinger, P.A., Casey, P.J., Jan, Y.N., and Jan, L.Y. (1995).  Evidence that direct binding of Gßγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation.  Neuron 15:1133-1143.  [PubMed]

  47. Yang, J., Jan, Y.N., and Jan, L.Y. (1995).  Control of rectification and permeation by residues in two distinct domains in an inward rectifier K+ channel.  Neuron 14:1047-1054.  [PubMed]

  48. Reuveny, E., Slesinger, P.A., Inglese, J., Morales, J.M., Iñiguez-Lluhi, J.A., Lefkowitz, R.J., Bourne, H.R., Jan, Y.N., and Jan, L.Y. (1994).  Activation of the cloned muscarinic potassium channel by G protein βγ subunits.  Nature 370:143-146.  [PubMed]

  49. Kubo, Y., Reuveny, E., Slesinger, P.A., Jan, Y.N., and Jan, L.Y. (1993).  Primary structure and functional expression of a rat G protein coupled muscarinic potassium channel.  Nature 364:802-806.  PMID: 8355805 [PubMed]

  50. Kubo, Y., Baldwin, T.J., Jan, Y.N., and Jan, L.Y. (1993).  Primary structure and functional expression of a mouse inward rectifier potassium channel.  Nature 362:127-133.  PMID 7680768 [PubMed]

 

Trafficking channels and receptors

  1. Xiao, S.H., and Jan, L.Y. (2009) A gate keeper for axonal transport. Cell 136(6):996-998. PMID: 19303842 [PubMed]

  2. Chung, HJ., Qian, X., Ehlers, M., Jan, YN., Jan, LY. (2009) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. Proc Natl Acad Sci USA. 106(2):629-34. PMCID: 2613039 [PubMedCentral]

  3. Chung, HJ., Ge, WP., Qian, X., Wiser, O., Jan, YN>, Jan, LY. (2009) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term protentiation. Proc Natl Acad Sci USA. 106(2):635-40. PMCID: PMC2613041 [PubMedCentral]

  4. Haass, F.A., Jonikas, M., Walter, P., Weissman, J.S., Jan, Y.N., Jan, L.Y., and Schuldiner, M. (2007). Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc. Natl. Acad. Sci. USA 104:18079-18084.  [pdf]

  5. Chang, W., Tu, C., Cheng, Z., Rodriguez, L., Chen, T.H., Gassmann, M., Bettler, B., Margeta, M., Jan, L.Y., and Shoback, D. (2007). Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J. Biol. Chem. 282:25030-25040.  [PubMed]

  6. Gong, Q., Weide, M., Huntsman, C., Xu, Z., Jan, L.Y., Ma D. (2007). Identification and characterization of a new class of trafficking motifs for controlling clathrin-independent internalization and recycling.  J. Biol. Chem. 17:13087-13097.  [PubMed]

  7. Shaw, R., Fay, A., Puthenveedu, M.A., von Zastrow, M., Jan, Y.N., and Jan, L.Y. (2007). Microtubule plus end tracking protein target gap junctions directly from the cell interior to adheren junctions. Cell 128:547-560.  [PubMed]

  8. Gu, C., Zhou, W., Puthenveedu, M.A., Xu, M., Jan, Y.N., and Jan, L.Y. (2006). The Microtubule Plus-End Tracking Protein EB1 Is Required for Kv1 Voltage-Gated K(+) Channel Axonal Targeting. Neuron 52:803-816.

  9. Lai, H.C., and Jan, L.Y. (2006). The distribution and targeting of neuronal voltage-gated ion channels. Nat. Rev. Neurosci. 7:548-562.  [PubMed]

  10. Chung, H.J., Jan, Y.N., and Jan, L.Y. (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc. Natl. Acad. Sci. USA 103:8870-8875.  [PubMed]

  11. Ma, D., and Jan, L.Y. (2002). ER transport signals and trafficking of potassium channels and receptors. Curr. Opin. Neurobiol. 12:287-292.  [PubMed]

  12. Gu, C., Jan, Y. N., and Jan, L. Y. (2003)  A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channel. Science 301:646-649.  PMID 12893943 [PubMed]

  13. Hu, K., Huang, C. S., Jan, Y.N., and Jan, L.Y. (2003)  ATP-sensitive potassium channel traffic regulation by adenosine and protein kinase C.  Neuron 38:417-432.  [PubMed]

  14. Ma, D., and Jan, L.Y. (2002).  ER transport signals and trafficking of potassium channels and receptors.  Curr. Opin. Neurobiol. 12:287-292.  [PubMed]

  15. Ma, D., Zerangue, N. Raab-Graham, K., Fried, S.R., Jan, Y.N., and Jan, L.Y. (2002).  Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart.  Neuron 33:715-729.  PMID: 11879649[PubMed]

  16. Zerangue, N., Malan, M.J., Fried, S.R., Dazin, P.F., Jan, Y.N., Jan, L.Y., and Schwappach, B. (2001).  Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells.  Proc. Natl. Acad. Sci. USA 98: 2431-2436.  [PDF]

  17. Ma, D., Zerangue, N., Lin, Y.-F., Collins, A., Yu, M., Jan, Y.N., and Jan, L.J. (2001).  Role of ER export signals in controlling surface potassium channel numbers.  Science 291:316-319.  PMID 11209084 [PubMed]

  18. Margeta-Mitrovic, M., Jan, Y.N., and Jan, L.Y. (2000).  A trafficking checkpoint controls GABAB receptor heterodimerization.  Neuron 27:97-106.  [PubMed]

  19. Whistler, J.L., Chuang, H.-H., Chu, P., Jan, L.Y., and von Zastrow, M. (1999).  Functional Dissociation of m opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction.  Neuron 23:737-746.  [PubMed]

  20. Zerangue, N., Schwappach, B., Jan, Y.N., and Jan, L.Y. (1999).  A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane KATP channels.  Neuron 22:537-548.  [PubMed]

 

Channel families-evolution

  1. Yang, S.B., and Jan, L.Y. (2008) Thrilling moment of an inhibitory channel. Neuron 58:823-824.  [PDF]

  2. Chung, H.J., and Jan L.Y. (2006). Channeling to the nucleus. Neuron 52:937-940.  [PubMed]

  3. Bichet, D., Lin, Y.-F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N., and Jan, L.Y. (2004). Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci USA 101:4441-4446.  [PDF]

  4. Jan, L.Y., and Jan, Y.N. (1997).  Cloned potassium channels from eukaryotes and prokaryotes.  Annu. Rev. Neurosci. 20:91-123.  [PubMed]

  5. Jan, L.Y., and Jan, Y.N. (1994).  Potassium channels and their evolving gates.  Nature 371:119-122.  [PubMed]

  6. Jan, L.Y., and Jan, Y.N. (1992).  Tracing the roots of ion channels.  Cell 69:715-718.  [PubMed]

  7. Jan, L.Y., and Jan, Y.N. (1990).  How might the diversity of potassium channels be generated?  Trends Neurosci. 13:413-419.  [PubMed]

  8. Jan, L.Y., and Jan, Y.N. (1990).  A superfamily of ion channels.  Nature 345:672.  [PubMed]

 

New fluorescent probes for studying channel function

  1. Chi, N.C., Shaw, R.M., De Val, S., Kang, G., Jan, L.Y., Black, B.L., and Stainier, D.Y.R. (2008). Foxn4 directly regulates tbx2b expression and atioventricular canal formation. Genes & Development 22:734-739.  [PDF]

  2. Cohen, B.E., Pralle, A., Yao, X-J, Swaminath, G., Gandhi, C., Jan, Y.N., Kobilka, B.K., Isacoff, E.Y., and Jan, L.Y. (2005) A fluorescent probe designed for studying protein conformational change. Proc. Natl. Acad. Sci. USA 102:965-970.  [PubMed]

  3. Cohen, B.E., McAnaney, T.B., Park, E.S., Jan, Y.N., Boxer, S.G., and Jan, L.Y. (2002). Probing protein electrostatics with a synthetic fluorescent amino acid.  Science 296:1700-1703.   [Abstract]  [PubMed]

 

Potassium channels and disease

  1. Huang, X., Dubuc, A.M., Hashizume, R., Berg, J., He, Y., Wang, J., Chiang, C., Cooper, M.K., Northcott, P.A., Taylor, M.D., Barnes, M.J., Tihan, T., Chen, J., Hackett, C.S., Weiss, W.A., James, C.D., Rowitch, D.H., Shuman, M.A., Jan, Y.N., and Jan, L.Y. (2012) Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 26:1780-96. PMID: 22855790. [PubMedCentral]

  2. Lee, H.Y., and Jan, L.Y. (2012) Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels. Curr Opin Neurobiol. PMCID: PMC3393774. [PubMedCentral]

  3. Yang, S.B., Lee, H.Y., Young, D.M., Tien, A.C., Rowson-Baldwin, A., Shu, Y.Y., Jan, Y.N., and Jan, L.Y. (2011) Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity. J Mol Med. PMID: 22105852 [PDF]

  4. Lee, H.Y., Ge, W.P., Huang, W., He, Y., Wang, G.X., Rowson-Baldwin, A., Smith, S.J., Jan, Y.N., and Jan, L.Y. (2011) Bidirectional Regulation of Dendritic voltage-Gated Potassium Channels by the Fragile X Mental Retardation Protein. Neuron 72:630-642. [PDF]

  5. Young, DM., Schenk, AK., Yang, SB., Jan, YN., Jan, LY. (2010) Altered ultrasonic vocalizations in a tuberous sclerosis mouse model of autism. Proc Natl Acad Sci USA. 107:11074-11079. PMCID: PMC2890736 [PubMedCentral]

  6. Thayer, D.A., and Jan, L.Y. (2010) Mechanisms of distribution and targeting of neuronal ion channels. Curr Opin Drug Discov Devel. 13:559-567.  PMID: 20812147 [PubMedCentral]

  7. Fay, A.J., Qian, X., Jan, Y.N., and Jan, L.Y. (2006). SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes. Proc. Natl. Acad. Sci. U.S.A. 103:17548-17553.

  8. Chung, H.J., Jan, Y.N., and Jan, L.Y. (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc. Natl. Acad. Sci. USA 103:8870-8875.  [PubMed]

  9. Cooper, E.C., and Jan, L.Y. (2003).  M-channels: neurological diseases, neuromodulation, and drug development.  Arch. Neurol. 60:496-500.  [PubMed]

  10. Mitrovic, I., Margeta-Mitrovic, M., Bade, S., Stoffel, M., Jan, L.Y., and Basbaum, A.I. (2003).  Contribution of GIRK2-mediated postsynaptic signaling to opiate and a2-adrenergic analgesia and analgesic sex differences.  Proc. Natl. Acad. Sci USA 100:271-276.   PMCID: PMC140949 [PubMedCentral]

  11. Pei, L., Wiser, O., Slavin, A., Mu, D., Powers, S., Jan, L. Y. and Hoey, T. (2003).  Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.  Proc. Natl. Acad. Sci. U.S.A. Early Edition [PDF]

  12. Mu, D., Chen, L., Zhang, X., See, L.-H., Koch, C.M., Yen, C., Tong, J.J., Spiegel, L., Nguyen, K.C.Q., Servoss, A., Peng, Y., Pei, L., Marks, J.R., Lowe, S., Hoey, T., Jan, L.Y., McCombie, W.R., Wigler, M.H., and Powers, S. (2003).  Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.  Cancer Cell 3:297-302.  [PubMed]

  13. Cooper, E.C., Aldape, K.D., Abosch, A., Barbaro, N.M. Berger, M.S. Peacock, W.S. Jan, Y.N. and Jan, L.Y. (2000)  Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.  Proc. Natl. Acad. Sci. USA 97: 4914-4919.   [PubMed]

  14. Cooper, E.C., and Jan, L.Y. (1999).  Ion channel genes and human neurological disease: recent progress, prospects, and challenges.  Proc. Natl. Acad. Sci. USA 96:4759-4766.   [PDF]

  15. Stoffel, M., and Jan, L.Y. (1998).  Epilepsy genes: excitement traced to K+ channels.  Nature Genetics 18:6-8.  [PubMed]

 

Calcium-activated chloride channels

  1. Tien, J., Lee, H.Y., Minor, D.L. Jr., Jan, Y.N., and Jan, L.Y. (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). PNAS USA 110:6352-7. PMID: 23576756. [PubMedCentral]

  2. Huang, W.C, Xiao, S., Huang, F., Harfe, B.D., Jan, Y.N., and Jan, L.Y. (2012) Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons. Neuron 74:179-192. PMID: PMC3329964. [PDF]

  3. Huang, F., Zhang, H., Wu, M., Yang, H., Kudo, M., Peters, C.J., Woodruff, P.G., Solberg, O.D., Donne, M.L., Huang, X., Sheppard, D., Fahy, J.V., Wolters, P.J., Hogan, B.L., Finkbeiner, W.E., Li, M., Jan, Y.N., Jan, L.Y., Rock, J.R. (2012) Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. PNAS USA 109:16354-9. PMCID: PMC3479591. [PubMedCentral]

  4. Berg, J., Yang, H., and Jan, L.Y. (2012) Ca2+-activated Cl-channels at a glance. J. Cell Sci. 125:1367-1371. PMCID: PMC3336373. [PDF]

  5. Huang, F., Wong, X., and Jan, L.Y. (2012) International Union of Basic and Clinical Pharmacology. LXXXV: Calcium-Activated Chloride Channels. Pharmacol Rev 64:1-15. PMID: 22090471. [PDF]

  6. Schroeder, B.C., Cheng, T., Jan, Y.N., Jan, L.Y. (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134 (6): 1019-1029. PMCID: PMC2651354 [PubMedCentral]

  7. Huang, F., Rock, J.R., Harfe, B.D., Cheng, T., Huang, X., Jan, Y.N., Jan, L.Y. (2009) Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci USA 106:21413-8. PMCID: 2781737.   [PubMedCentral]

 

Glia

  1. Yang, H., Kim, A., David, T., Palmer, D., Jin, T., Tien, J., Huang, F., Cheng, T., Coughlin, S.R., Jan, Y.N., and Jan, L.Y. (2012) TMEM16F Forms a Ca(2+)-Activated Cation Channel Required for Lipid Scrambling in Platelets during Blood Coagulation. Cell 151:111-22. PMID: 23021219. [PubMedCentral]

  2. Ge, W.P., Miyawaki, A., Gage, F.H., Jan, Y.N., and Jan, L.Y. (2012) Local generation of glia is a major astrocyte source in postnatal cortex. Nature. PMID: 22456708. [PubMedCentral]

 

 

 
 
   
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