Selected publications from the lab are listed below. Complete lists of publications by each lab member can be found in their entry in the people section.


Julius D and Nathans J (2012) Signaling by Sensory Receptors. Cold Spring Harb Perspect Biol Jan 1;4(1):a005991

Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, and Julius D. (2011) A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature 479:410-4

Julio F. Cordero-Morales, Gracheva EO, David Julius (2011) Cytoplasmic ankyrin repeats transient receptor potential A1(TRPA1) dictate sensitivity to thermal and chemical stimuli. PNAS 108:E1184-91

Gracheva EO, Cordero-Morales JF, González-Carcacía JA, Ingolia NT, Manno C, Aranguren CI, Weissman JS, and Julius D (2011) Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats. Nature 476: 88-91

Bohlen CJ, Priel A, Zhou S, King D, Siemens J and Julius D (2010) A bivalent tarantula toxin activates the capsaicin receptor, TRPV1, by targeting the outer pore domain. Cell 141: 834-845

Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, Chesler AT, Sánchez EE, Perez JC, Weissman JS and Julius D (2010) Molecular basis of infrared detection by snakes. Nature 464: 1006-1011.

Basbaum, AI, Bautista DM, Scherrer, G and Julius D (2009) Cellular and molecular basis of pain – Leading Edge Review. Cell 139: 267-284.

Myers, BR, Sigal, YM, and Julius D (2009) Evolution of thermal response properties in a cold-activated TRP channel. PLoS ONE 4: e5741.

Myers BR, Saimi Y, Julius D, and Kung C (2008) Multiple unbiased prospective screens identify TRP channels and their conserved gating elements. J Gen Physiol 132: 481-6.

Bhattacharya M.R. et al. (2008) Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons. Proc Natl Acad Sci U S A. 105: 20015-20.

Bautista et al. (2008) Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels. Nat Neurosci.11: 772-9.

Myers B.R., Bohlen C.J., and Julius D. (2008) A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating. Neuron 58: 362-73.

Meyers B. and Julius D. (2007) TRP channel structural biology: new roles for an old fold. Neuron 54: 847-50.

Bautista et al. (2007) The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448: 204-8.

Bautista et al. (2006) TRPA1 mediates the inflammatory action of environmental irritants and pro-algesic agents. Cell 124: 1269-1282.

Tsuruda, P.R., Julius, D., and Minor, D.L. (2006) Coiled-coils direct assembly of a cold-activated TRP channel. Neuron 51: 201-212.

Siemens J. et al. (2006) Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 444: 208-212.

Haynes, S.E. et al. (2006) The P2Y12 receptor regulates microglial activation by extracellular nucleotides. Nature Neurosci. 9: 1512-1519.

Hinman A. et al. (2006) TRP channel activation by reversible covalent modification. Proc Natl Acad Sci 103: 19564-19568.

Bautista, DM, et al (2005) Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci U S A. 102(34):12248-52.


Chuang, H., Neuhausser, W.M., Julius, D. (2004) The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron 43:859-69.

Jordt, SE, Bautista, DM, Chuang, H, McKemy, DD, Zygmunt, PM, Högestätt, ED, Meng, ID, and Julius, D. (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427: 260-265.

Jordt SE, McKemy DD, Julius D. (2003) Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr Opin Neurobiol. 13: 487-492.

Prescott, E.D. and Julius, D. (2003) A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity. Science 300: 1284-1288.

Jordt, S-E. and Julius, D. (2002) Molecular basis of species-specific sensitivity to "hot" chili peppers. Cell 108: 421-430.

McKemy, D.D., Neuhausser, W.M., and Julius, D. (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-59

Zeitz, K.P., Guy, N., Malmberg, A.B., Dirajlal, S., Martin, W.J., Sun, L., Bonhaus, D.W., Stucky, C.L., Julius, D. and Basbaum, A.I. (2002) The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J. Neurosci. 22: 1010-1019.

Hollopeter. G., Jantzen, H-M., Vincent, D., Li, G., England, L., Ramakrishnan, V., Yang, R-B., Nurden, P., Nurden, A., Julius, D. and Conley, P.B., (2001) Molecular identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409: 202-207.

Chuang, H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V., and Julius, D. (2001) Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 411: 957-962.

Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001 Sep 13;413(6852):203-10.

Jordt SE, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8134-9.

Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 2000 Apr 14;288(5464):306-13.


Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sorgard M, Di Marzo V, Julius D, Hogestatt ED. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature. 1999 Jul 29;400(6743):452-7.

Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature. 1999 Apr 1;398(6726):436-41.

Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron. 1998 Sep;21(3):531-43.


England, L.E., Imperial, J., Jacobsen, R., Craig, A.G., Gulyas, J., Akhtar, M., Rivier, J., Julius, D., and Olivera, B. (1998) Inactivation of a serotonin-gated ion channel by a novel polypeptide toxin from marine snails. Science 281: 575-578.

Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 1997 Oct 23;389(6653):816-24.




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