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Rubenstein Lab

Primary Investigator

Rubenstein, John L. R., M.D., Ph.D. Rubenstein, John L. R., M.D., Ph.D.

  • Current Title(s):
    • Nina Ireland Distinguished Professor in Child Psychiatry
    • Professor of Psychiatry
  • Biography Summary:
    • John Rubenstein, M.D., Ph.D., Researcher of basic science in the Department of Psychiatry at UCSF
  • First Year on UCSF Faculty: 1991
  • Education:
    • M.D. Stanford University, 1983
    • PhD. Stanford University, 1982
    • Pasteur Institute, Postdoctoral Fellowship in Developmental Biology
    • Stanford University, Residency in Adult Psychiatry
    • Stanford University, Residency in Child Psychiatry
  • Research Training:
    • 1972: Norman Shumway and Randall Morris, Stanford Medical School
    • 1973: Paul Wolf, Stanford Medical School
    • 1974: Arthur Kornberg and William Wickner, Stanford Medical School
    • 1975: A.T. Ganesan, Stanford Medical School
    • 1975-1977: David Clayton and Douglas Brutlag, Stanford Medical School
    • 1977: B.S. in Chemistry, Stanford University
    • 1977-1980: Harden McConnell, Stanford Department of Chemistry
    • 1980-1982: James Rothman, Stanford Medical School
    • 1982: Ph.D. in Biophysics, Stanford University
    • 1984-1986: Francois Jacob and Jean Francois Nicolas, Pasteur Institute, Paris
    • 1987-1988: Jack Barchas, Stanford Medical School
    • 1988-1991: Roland Ciaranello, Stanford Medical School
  • Clinical Expertise:
    • Developmental Disorders
  • Educational Expertise:
    • Developmental Neurobiology
  • Research Areas:
    • Development of the forebrain

University of California, San Francisco, Department of Psychiatry
Box 2611 , Mission Bay 284C
University of California, San Francisco
San Francisco, CA. 94143 - 2611
Phone: (415) 476-7862,  Fax: (415) 502-7618 or (415) 476-7884,  
Email: john.rubenstein@ucsf.edu


Professional Biography
John Rubenstein, MD, Phd is a Professor in the Department of Psychiatry at the University of California San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain.

In the mammalian embryo, the forebrain is the portion of the neural tube where primitive cells are organized to form the cerebral cortex, the basal ganglia and other components of the adult brain -- the structures of the human brain most involved in key functions such as speech, language, cognition and fine motor skills.

Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.


Publications on PubMed